Objective To investigate the preventive and therapeutic effects of lamivudine and entecavir on hepatitis B virus (HBV)reacti-vation among non-Hodgkin lymphoma (NHL)patients with chronic HBV infection during chemotherapy.Methods From January 2008 to April 2013,a total of 94 NHL patients with HBV infection were recruited from our hospital and divided into lamivudine treatment group and entecavir treatment group.The lamivudine treatment group received chemotherapy with lamivudine (100 mg/d),and the entecavir treatment group received chemotherapy with entecavir (0.5 mg/d).The rates of virological breakthrough,primary non -response,and virological breakthrough-related hepatitis flare were compared between groups.The t-test was used for comparison between two groups of independent samples;one-way analysis of variance was conducted for comparison between three groups of independent samples;the chi -square test was used to conduct intergroup comparison.Results For the patients with HBV DNA levels lower than 103 copies/ml before anti -HBV treatment,no significant difference was found in the rate of virological breakthrough or rate of hepatitis flare between lamivudine treatment group and entecavir treatment group (χ2 =1.03,P>0.05).For the patients with HBV DNA levels higher than 103 copies/ml before anti-HBV treatment,the lamivudine treatment group had a virological breakthrough rate of 37.5%,a primary non-response rate of 9.4%,a hepatitis flare rate of 28.1%,and a liver failure rate of 3.1%,and the aforementioned rates for entecavir treatment group were 3.1%,0, 0,and 0,respectively;there were significant differences in the rates of virological breakthrough and hepatitis flare between the two groups (χ2 =11.68,P<0.05;χ2 =10.47,P<0.05).Conclusion Among NHL patients with HBV infection whose HBV DNA levels are lower than 103 copies/ml,the preventive and therapeutic effects of lamivudine and entecavir on HBV reactivation are similar;among NHL patients with HBV infection whose HBV DNA levels are higher than 103 copies/ml,those treated with entecavir have lower rates of virological break-through and hepatitis flare than those treated with lamivudine,which helps patients have a smoother progress of chemotherapy.

The rather serious compliation of vertebroplasty is caused by bone cement leakage into adjacent structure but recent research suggests that even without cement leakage during vertebroplasty,patients could also experience with cardiovascular changes sometimes. Cytotoxicity of bone cement,nervous reflex,fat embolism and alteration of intravertebral pressure may be responsible for these changes. (J Intervent Radiol,2006,15: 377-381)

A method for the quantitative determination of tetrandrine in "Zhitong Ruanjiaonang"wasdeveloped by means of TLC densitometry. The method is easy, rapid, accurate, and repro-ducible . The average recovery was 99.98%.

Bacteria ; cytology ; metabolism ; Quorum Sensing ; Signal Transduction

Biomedical Research ; trends ; China ; Dental Pulp ; physiology ; Humans

Objective To establish a method for determination of total hardness in drinking water by using automatic potentiometric titrator.Methods Dynamic equivalence point titration(DET)and monotonic equivalence point titration(MET)mode was used to determine the high total hardness and low total hardness of drinking water samples respectively.Results Used DET mode to determine the high total hardness,the relative standard deviation(RSD)was 0.69%～1.72% and the recovery rate was 101.5%～102.2%.Used MET mode to determine the low total hardness,RSD was 3.49%～4.00% and the recovery rate was 95.8%- 103.6%.Conclusion This method is rapid,simple,accurate,precise and applicable to the determination of total hardness in drinking water in low and high levels.

Air ; analysis ; Air Pollutants, Occupational ; analysis ; Chromatography, Gas ; methods ; Hydrocarbons, Chlorinated ; analysis

Cuiru oral liquid (COL ) for the promotion of lactation is prepared from an aqueous extract of Angelica sinensis, Astragalus membranaceus (Fisch.) Bge., Rehmbnnia glutinosa Libosch.,et al. Its formulatiou and processing were briefly desctibed, and the quality standard and stability of the finished product were studied. Results showed that the formu lation processing and stability of COL were suitable for clinical trial. Moreover, its pharmacology was briefly described.

Objective To evaluate the clinical value of vertebral body venography in performance of percutaneous vertebroplasty(PVP). Methods 92 patients with 124 vertebraes underwent PVP. Before injecting the bone cement, venography was performed with injection of nonionic contrast material into vertebral body. 124 vertebraes were classified into four groups according to the results of vebgrophy. Group A: no draining veins displayed; group B: draining veins appeared late; group C: draining veins appeared ahead of time; group D: draining veins appeared ahead of time, then intervention such as adjusting the puncture needle's position or gelatin sponge embolization of vein was performed to delay the appearance of veins. Results 94 of 124 vertebraes displayed draining veins. According to the results of vebgrophy, there're 30 vertebraes in group A, 25 in group B, 30 in group C, 39 in group D. Thirty-seven vertebraes demonstrated cement extravasation, cement entering vein was observed in sixteen vertebraes and two patients among them had pulmonary embolism. Venograms showed all correlative venous extravasation. Bone cement extravasation rate of each groups was 20.0%, 24.0%, 56.7% and 20.5% respectively. Moreover, extravasation rate of group C was higher than any other group. Pain reduction was observed in 88 of 92 patients after 30 days of the operation, the rate of pain relief was 95.7%. Conclusion Vertebral body venography could describe the velocity of venous blood flow within vertebral body and predict the direction of bone cement leaking to veins effectively, which could provid valuable information in takeing some measures to prevent bone cement leaking into veins. Vertebral body venography has very impotant clinical value in improving the safety and preventing complication of PVP.

Objective To analyze the efficacy and safety of CT-guided percutaneous injection of the fibrin glue bv double needle technique to treat sacral cyst.Methods Clinical data of 20 cases with double-needle injection of fibrin glue technology to treat sacral cyst were retrospectively analyzed.All patients had varying degrees of sacral nerve root compression symptoms.The treatment for sacral cyst was carried out after clear diagnosis was made.On the basis of CT-guided percutaneous injection of fibrin glue,the improved CT-guided percutaneous injection of fibrin glue by double-needle technique was used to treat these patients.The average dose of fibrin glue was(5.9 ± 2.4)ml.The clinical results of improvement as to pain and neurological function were evaluated after follow-up of an average of 17 months.The assessment criteria were as follows:excellent,complete resolution of signs and symptoms,with the patient returning to his or her regular employment and no recurrence of cysts during 1 year of follow-up,good,symptoms and signs in the legs and perineal region resolved but with persistent pain in the lumbosacral region,which did not interfere with the patient' s regular work (the cysts did not recur for 6 months during follow-up),fair,no improvement in clinical symptoms,but a decrease in cyst size on the imaging study,poor,no improvement in clinical symptoms and no observed changes in cyst size in imaging studies or recurrence.Results Most patients experienced some degree of pain relief and functional improvement after fibrin glue therapy,with most experiencing complete or marked resolution of clinical symptoms.Nine patients reported excellent recovery,8 reported good recovery,2 reported fair recovery,and 1 reported poor recovery.The overall percentage of positive outcomes (excellent and good recovery) was 85％.No serious postoperative complications were discovered.Conclusions CT guided percutaneous injection of the fibrin glue bydouble needle technique to treat sacral cyst is an ideal method.Double needle technique is simple,safe and reliable.