Despite efforts to develop treatment technology for cardiac arrest (CA), CA incidence and mortality rates are still high.[1,2] A recent study of CA patients in emergency departments revealed that the incidence of CA is increasing annually, and the in-hospital survival rate of CA patients is only approximately 28.7%.[3] Echocardiography has been widely used as an important monitoring tool in critical care and helps to identify the cause of shock, monitor hemodynamics, and guide fluid therapy utilization.[4] One study reported that approximately one-third of patients underwent formal echocardiography during hospitalization in the intensive care unit (ICU).[5]

Uveitis is a kind of refractory blinding eye diseases.Noninfectious uveitis is an important part of uveitis,which is thought to be an autoimmune disease,and systemic immunosuppressive therapy is usually required to prevent visual loss.As a selective T-cell inhibitor,cyclosporine A is one of the most widely used immunosuppressants,and has obvious therapeutic effect on many kinds of uveitis.Cyclosporine A combined with glucocorticoid,other immunosuppressants or biological agents can improve the therapeutic effect and reduce the side effects.Recently,the inhibitory effect on glucocorticoid-resistant Th17 cells and topical application of cyclosporine A,show its advantage and potential in the treatment of noninfectious uveitis.

Objective To explore the clinical efficacy of the combination of the vaginal and high frequency electric wave loop(LEEP) in the treatment of cervical precancerous lesions.Methods The clinical data of 76 cases with cervical precancerous lesions confirmed by postoperative pathological examination were collected,Pathologic biopsy was conducted under colposcope.For patients with operative indication, LEEP operation was carried out under colposcope and analyzed vaginal microscopic pathological biopsy diagnosis accurate rate.The operation time,bleeding volume and treatment were observed.Results Satisfactory colposcopy and biopsy results difference had statistical significance;colposcopy with biopsy diagnosis accurate rate was 90.79%.The average operation time was (6.42±1.21)min.The mean operative bleeding was (10.45±2.31)mL.Postoperative 3 months, TCT negative rate was 95.83%(92/96).After 6 months of TCT negative rate was 100.00%(76/76).Conclusion LEEP combined with vaginal cytology in the treatment of cervical precancerous lesions has less invasion,less bleeding,shorter hospitalization time,and can effectively remove the lesion site,it is worthy of recommending.

Objective To explore the value of laparoscopic assisted vaginal hysterectomy in the treatment of large uterine fibroids.Methods 76 patients with giant hysteromyoma were randomly divided into two groups.38 patients in the control group underwent conventional open surgery, 38 cases in the observation group received laparoscopic assisted vaginal hysterectomy surgical treatment.The operation time, amount of bleeding in operation, postoperative anal exhaust time, get out of bed activity time, length of operation time and the postoperative complications were compared between the two groups.Results In the observation group, the operation bleeding[(65.28±4.86)mL], operation time[(76.29±5.32)min], postoperative anal exhaust time[(10.18±2.01)h], postoperative bed activity time[(14.02±2.18)h] and hospitalization time[(4.05±1.26)days] were significantly better than those of the control group, the differences were statistically significant (t=6.830,8.066,6.598,13.747,6.303,all P<0.05).The incidence rate of postoperative complication of the observation group was 5.26%, which was lower than 15.79% of the control group, the difference was statistically significant (x2=5.887,P<0.05).Conclusion The treatment of giant hysteromyoma patients with laparoscopic assisted vaginal hysterectomy the uterus resection has more advantages than the traditional laparotomy, with less amount of bleeding, fast postoperative recovery and less postoperative complications, it is worthy of recommendation.

OBJECTIVE:To investigate the analgesia effect of low-dose ketamine combined with sufentanil after radical sur-gery of esophageal cancer. METHODS:Totally 153 patients of pre-implementation esophageal cancer surgery were randomly divid-ed into group A,B and C. After induction of anesthesia in patients in each group,patients in group A administered sufentanil 2 μg/kg;group B were treated with sufentanil 2.5 μg/kg;group C were treated with sufentanil 2 μg/kg + ketamine 85 μg/(kg·h). Visual analog(VAS)score and Ramsay score before and after anesthesia 4,8,16,24 and 48 h,analgesia pump pressing times and inci-dence of adverse reactions in each group were observed. RESULTS:Ramsay score in 4,8 and 16 h in each group were significant-ly higher than before anesthesia,the differences were statistically significant(P<0.05),however,compared with before,there was no significant difference in the Ramsay score in 48 h among each group(P<0.05);VAS scores in each group(except for group C in 48 h) at each time point were significantly higher than before,group C

OBJECTIVE:To improve the quality standard of Shexiang qutong liniment. METHODS:TLC was used for qualita-tive identification of Resina draconis and Rehmannia. The determination of total solids and ether-soluble extracts in the preparation was detected. GC was used for the content determination of muscone:the column was Thermo-TG-WAXMS capillary column by programmed temperature,the detector was FID detector,the detector temperature was 250 ℃,inlet temperature was 200 ℃,carri-er gas was high purity nitrogen at a flow rate of 1.0 ml/min,split ratio was 5:1,and the injection volume was 1 μl. RESULTS:The TLC pots of R.draconis and Rehmannia were clear with good separation. The total solids in preparations were not less than 0.6%,and extracts were not less than 3.0%. The linear range of muscone concentration was 15.21-243.36 μg/ml(r=0.9998);RS-Ds of precision,stability and reproducibility tests were lower than 2%;recovery was 97.70%-99.63%(RSD=0.78%,n=6). CON-CLUSIONS:The established method can be used for the quality control of Shexiang qutong liniment.

Objective Discussion of diagnosing insulinoma.Methods Retrospective analysis based on 45 cases of insulinoma patients that are collected by General Surgery Department in the First Affiliated Hospital of Zhengzhou University from June 2008 to October 2014.Results Forty-five cases of patients with insulinoma including 41 cases (91.11％) of functional insulinoma and 4 cases (8.89％) of non-functional insulinoma.Apply selective arteriography,preoperative ultrasound,intraoperative ultrasound and CT to diagnosis.Forty-five cases of patients with insulinoma,in which 18 cases with laparoscopic simple tumor resection,6 cases with laparoscopic splenectomy and tail of the pancreas resection;45 cases of insulinoma with laprotomy,in which 8 cases with pancreaticoduodenectomy,12 cases which the tumors were located in the neck,neck-line of the pancreas with local excision of the pancreas and pancreatic tail-jejunal Roux-en-Y anastomosis,one cases of laparotomy found no placeholder.Conclusions Surgery removal is currently the most successful way to eliminate insulinoma.And localization diagnosis can determine the outcome of the surgery.Co-operation of surgery removal and localization diagnosis can be the optimal approach to diagnose certain insulinoma.

Abdominal aortic aneurysm (AAA) is a common fatal aortic disease.The rupture of AAA is the procession affected by multiple factors.Besides physiological,pathological and biochemical changes,morphological and biomechanical alteration can also influence this procession.The progress of rupture risk evaluation through morphological and biomechanical characteristics of AAA were reviewed in this article.

Objective To investigate the perinatal outcomes of isolated single umbilical artery (ISUA) in full-term birth. Methods We performed a retrospective study of 82 252 pregnant women (aged<35 years;singleton; full-term live birth; no known chromosomal/structural anomalies) who delivered between January 1, 2011 and January 1, 2012 in 39 hospitals in 14 cities in China. There were 273 cases with ISUA as study group and 1 092 cases with a three-vessel cord selected in a 1∶4 ratio as control group. Perinatal outcomes including delivery modes (vaginal delivery or emergency cesarean section for fetal reasons), birth weight and height, placental weight, umbilical cord length, Apgar scores at 1 min, and rate of neonatal asphyxia were analyzed retrospectively. Data were analyzed using the Chi-square test, two independent samples t-test or rank sum test. Results The incidence of ISUA was 0.3%(273/82 252). There was no difference between the two groups with regard to maternal age, parity, gravidity, smoking status, gestational age at birth, or rate of complications during pregnancy (gestational diabetes mellitus or pregnancy-induced hypertension) (all P>0.05). The birth weight in ISUA group and control group was (3 259±463) and (3 344±411) g (t=3.689), birth hight was (48.6±2.7) and (49.7±1.9) cm (t=8.368), placental weight was (508±72) and (543±153) g (t=3.114), umbilical cord length was (52.6±8.1) and (53.7±7.5) cm (t=1.983), and Apgar scores at 1 min were 9.0 (8.0-10.0) and 10.0 (9.0-10.0) (Z=11.831), respectively; the values in the ISUA group were lower than those in control group (all P < 0.05). No significant differences were observed in the rate of vaginal delivery and emergeny cesarean section for fetal reasons between the ISUA group and control group [52.8%(144/273) and 49.9%(545/1 092),χ2=0.704;19.4%(25/273) and 15.7% (86/1 092), χ2=1.162; both P>0.05]. Conclusions ISUA does not increase emergency cesarean delivery rates for the fetal reasons, but the fetal growth and development may fall behind those with a three-vessel umbilical cord. Monitoring during pregnancy and delivery should be intensified for fetuses with ISUA.

Laboratory animal science has become a main support for the development of life science and has occupied an importance place in higher medical education.The paper analyzed the characteristics and problems of laboratory animal science and proposed the ideas of applying conformational memory teaching in laboratory animal science teaching from there aspects:teaching method,teaching frame and teaching effect.These measures established the foundation for the cultivation of applied talents with comprehensive competence.