4(3H)-quinazolinone derivatives were synthesized by the condensation of N-acetylanthranilic acid with aromatic amines or heteroaromatic amines, respectively. The obtained compounds were characterized by their melting point, elemental analysis and the mass, ultraviolet, infrared, 1H and 13C NMR spectra. The obtained derivatives of 4(3H)-quinazolinone were also biologically screened such as: hypnotic, analgesic, antibacterial and cytotoxic activity. 3-(2-hydroxy-3-pyridinyl)-2-methyl-4(3H)-quinazolinon (6) showed potential analgesic activity. No compounds showed hypnotic, cytotoxic and antibacterial activity.
Chemical synthesis ; Physiological Effects of Drugs ; N-acetylanthranilic acid