1.Anti-Acethylcholinesterase Activity of Some Mongolian Medicinal Plants
Jaal Ts ; Munguntsetseg B ; Batkhuu J
MONGOLIAN MEDICAL SCIENCES 2010;151(1):26-28
Acethylcholinesterase (AChE) inhibitors have been used in the treatment of Alzheimer’s disease (AD). Currently, the only effective treatment for AD disease targets the cholinergic system using anti-cholinesterase compounds. AD is progressive, degenerative disease characterized by memory loss, language deterioration, poor judgment, impaired visuospatial skills etc.
There are a few synthetic medicines, e.g. tacrine, donepezil and the natural product-based rivastigmine and galantamine to treat cognitive dysfunction and memory loss associated with AD. These approved drugs are limited in use due to their adverse side effects such as gastrointestinal disturbance and bioavailability problems. There still is great interest in fi nding better AchE inhibitors.
We have screened in this study the anti-acethylcholinesterase effects of 87 samples, which prepared from different parts of 43 plant species. Methanolic extracts of nine plants, namely Patrinia rupestris, Numpaea candida, Lespedeza hedysaroides, Pachypfeurum alpinum, Leontopodium Leontopodioides, Nonea pulla, Leontopodium compestre, Gypsophilea patrinii and Abies sibirica showed potent effect, their inhibition ratios were 39.65%, 42.22%, 38.06%, 40.55%, 38.82%, 35.1%, 35.85%, 35.3 % and 53.01%, respectively.
Our research shows that some Mongolian medicinal plants have anti-acetylcholinesterase activity, furthermore investigations needed to isolate pure bio-active compounds from these active plants and determine their chemical structures.
2. Oral health status in children with impaired hearing
Munguntsetseg L ; Alimaa B ; Oyunsuren SH ; Tsengunmaa A ; Tseyensuren S ; Batmunkh T ; Altanchimeg H ; Myanganzul P
Innovation 2016;2(1):14-17
Children with impaired hearing have communication and learning difficulty due to delay in the development of receptive and expression communications. Communication difficulties can often lead to social isolation and poor self-estimation. Oral health status in children with impaired hearing tends to be poor due to several reasons as difficulty of adequate training of caregiving parents, parents luck of information and effort. Aim: To study oral health status and oral education level among students of special school №29 for disabled children.A cross-sectional descriptive study. 224 students aged 6-22 years were selected for this study. Participants were subjected to oral examination and were asked to answer to the questionnairePrevalence of caries and DMFT index, dental plague, occlusion and the oral education levels were assessed. The caries prevalence was 95.9%, and the mean DMFT index was 5.5. Dental plaques were identified in 31.7-49.2% of subjects differing among age groups. Among examined children, 32% of subjects had a malocclusion and 18 children underwent cleft lip palate surgical treatment. According to questionnaire 21% of subjects reported that tooth brushing is not significant measure to maintain oral health, which shows that oral education level among subjects was low. Oral health status of children with impaired hearing was in a level comparable to that of healthy children, although the incidence of cleft lip and palate and gingivitis were higher.
3.Comparison of Helicobacter pylori Virulence Factors, Intcrleukin-1 Polymorphisms ni Patients and Endoscopic and Histological I-indiums of Stomach and Duodenum.
Bayasgalan.P ; Anarkhuu.B ; B. Munguntsetseg ; Ochbadrakh.B ; Bolormaa.E ; Maslov. V.E ; Narantsetseg.B ; Narmandali.B ; Gan-Orshih.L ; Ovunchimeg.J ; Tserenlham.S ; MunhjargalJ ; Enh-Ulzii.M ; Enh-Amar.A ; Oyuntsetseg.Kh ; Bira.N ; Suvd.B ; Khoshayar.T
Innovation 2009;6(2):72-77
BACKGROUND
The aim of the study is to detect and define the role of H. pylori virulence factors and host IL-1 polymorphisms to prevent from further gastric cancer.
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5ml of blood samples were collected from each of 42 patients who had abdominal complaint, after informed consent was obtained. All patients were Mongolian nationality. The biopsy specimens were stored in liquid nitrogen and homogenized before DNA isolation. After tissue lysation with proteinase K. DNA isolation was performed with "Promege" tissue kit. according to the manufacturer's instructions. PCR amplification of H. pylori gene loci was performed for the cagA gene and the vacAs mosaics vac As 1 and vacAs2.
RESULTS
Result of histological findings shows 84.7% from all patients were diagnosed with II. pylori infection 83% (35/42). Histologically LI'G 50% (42/21). Gastric atrophy 30% (42/13). Intestinal metaplasia 9% (42/4). Gastroduodcnal ulcer 4% (42/2), Dys¬plasia 11% (42/5), Adinocarcinoma 2% (42/1), 3 patients (42/3, 7%) were none patho¬logic change. 62% (26/42) patients infected with H. pylori, as determined by Urease test. H. pylori were investigated in all 42 patients and 83% (35/42) were infected with II. pylori, as determined by histology (haematoxylin- eosin and (iiemsa-stained). Strain characteristics of H. pylori were investigated in all 42 patients and 83% (35/42) were infected with //. pylori, as determined by UreC PCR.
Result of histological findings revealed Bacilla form 48,5% (17/35), Coccoid form 28,5% (12/35), mixed form 14% (5/35) from all patients were found //. pylori. 76% (13/17) of all patients were revealed coccoid form of H. pylori were taken anti-//. pylori treatment.
The vacAs 1 genotype was found in 38% (16/42) of all UreC+ patients, and cagA was found in 23% (10/42) of UreC+ patients. 16.9% of all patients were IL-RN*2 positive (7/42), (IL-1B 31C/51 IT).