1.A Case Report of Airway Stenting in Tracheal Compression Secondary to Right Subclavian Artery Pseudo-aneurysm
Muhammad Naimmuddin Abdul Azih ; How Soon HINA ; Kuan Yeh CHUNNA
The International Medical Journal Malaysia 2018;17(1):141-144
We report a 55-year old lady with the presentation of stridor and type II respiratory failure requiringtracheal intubation. She had right Horner’s syndrome associated with pleural effusion. Her chest radiographrevealed right upper zone lobulated opacities and therefore right Pancoast tumor was the initial diagnosis.However, her CECT thorax revealed a huge right subclavian artery pseudoaneurysm with severe trachealcompression. This rare condition imposed a significant diagnostic as well as therapeutic challenge. Vascularsurgery is the definitive treatment but it is associated with high risks. The exact role of rigid bronchoscopyfor airway stenting is unknown due to limited evidence available. Indeed, this form of central airwayobstruction may benefit from temporary tracheal stenting whilst the surgical repair of the lesion is planned.It may facilitate early weaning and allows less complicated airway control.
2.Intermittent EGFR-TKI Therapy is Associated with Durable Response in Advanced EGFR-Mutant NSCLC: A Case Report
Sin Nee Tan ; Aishah Ibrahim ; Megat Razeem Abdul Razak ; Muhammad Naimmuddin Abdul Azih ; Soon Hin How
Malaysian Journal of Medicine and Health Sciences 2023;19(No.2):341-343
Madam S, who diagnosed to have stage IV lung adenocarcinoma with exon 21 L858R point mutation (T3N2M1a)
was admitted for massive pericardial effusion in April 2016. She was ECOG 4 on admission. Her ECOG improved
to 1 after pericardial tapping and initiation of free sample erlotinib 100 mg daily. Repeated CT thorax post treatment
showed the disease was partial responded. Due to financial constraints, she had never bought any EGFR-TKI. She
was given a free sample of erlotinib intermittently for total of 12 months followed by intermittent afatinib supply for
2 years. Due to this limited supply, she took half doses of afatinib by cutting a 40 mg tablet once every few days to
sustain the continuation of cancer treatment. No major side effects were observed and she remained ECOG 0 with
good weight gain. Up to her last clinic visit in September 2021, her PFS was more than 5 years. Intermittent doses of
EGFR-TKI may prolong PFS in patients with advanced EGFRm+ NSCLC who has limited treatment options.
3.A Case of Foreign Body Aspiration Mimicking Asthma in Adult
Nurjasmine Aida Jamani ; Muhammad Naimmuddin Abdul Azih ; Raihanah Haroon ; Nur Shairah Mohd Shaari
Malaysian Journal of Medicine and Health Sciences 2023;19(No.5):428-430
Foreign body aspiration is uncommon in adults who have no known risk factors such as mental retardation, poor
dentition, or advanced age. Adults with foreign body aspiration are commonly misdiagnosed with bronchial asthma,
however, does not respond to standard bronchodilator treatment. A thorough history-taking, focused physical examination and a high index of suspicion is crucial in making the correct diagnosis. This paper reports an interesting
case of a 41- year-old woman with an undetected 10-year long foreign body aspiration which was misdiagnosed as
bronchial asthma.