Introduction: Musculoskeletal Disorder (MSD) is an injury that affects the movement of human body systems such as muscles, tendons, ligaments, nerves, blood vessels, and others. The prevalence of MSDs in Indonesia is 11.9% based on diagnosis and 24.7% based on symptoms. MSDs prevalence is 31.2% based on employment among farmers, fishermen, and workers. Methods: The design of this study has been included in observational research using a quantitative approach with Cross-Sectional study. Results: MSDs can appear based on gender, age, educational status, and non-medical supporting professions. Older workers tend to be at risk of developing MSDs complaints. Conclusion: To reduce the risk of complaints, work facilities such as ergonomic chairs and tables can be provided along with extension of work intervals. Workers must take advantage of good rest periods. There is no relationship between work tenure and MSDs complaints. If the working period is long, then it can cause boredom and the endurance of muscles as well as bones physically.