Objective To compare the dosimetric difference of proton therapy(PT)and X-ray intensity-modulated radiotherapy(IMRT)for cervical esophageal cancer.Methods The treatment planning of 10 patients with cervical esophageal cancer were selected for this study.One IMRT plan and 2 PT plans (PT1 plan:two opposed AP-PA beams;PT2 plan:two anterior-oblique beams and one posterior beam)were constructed for each patient.The isodose distribution and statistical data extracted from dose volume histograms were used for dose plan comparison.Results The conformal index(CI95%,defined as the ratio between the volume receiving at least 95%of the prescribed dose and the volume of PTV)of IMRT,PT1 and PT2 was 1.43,1.52 and 1.43(F=3.62,P<0.01),respectively.And the mean dose of PTV was 64.4 Gy,65.0 Gy and 63.6 Gy(F=12.06,P<0.01);the mean dose in normal tissue outside of PTV was 20.7 Gy,10.5 Gy and 10.6 Gy(F=77.60,P<0.01),in whole lung was 12.1 Gy,7.3 Gy and 8.4 Gy (F=15.87,P<0.01);the maximum dose in spinal cord was 41.4 Gy,34.9 Gy and 35.0 Gy(F=11.74,P<0.01),respectively.Conclusions Ail plans full file the requirements for PTV,however.PT plans can reduce radiation dose in surrounding normal significantly.The possibility is provided to escalate PT dose in PTV or to combine more aggressive chemotherapy.The PT1 plan full fills the clinical requirements.

Combined with safe mothcrhood project,in order to completely promote teaching quality,we should explore establishing a uniform,standardized,scientific and perfect teaching model of obstetric residents' standard training by analyzing the status and the difficulties in standard training of obstetric residents,and by adopting scientific and reasonable evaluation measures.

MicroRNAs(miRNAs) are a class of micro,endogenously-initiated non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. miRNAs have ability to negatively regulate the expression of genes involved in cell differentiation,proliferation,apoptosis and tumorigenesis.miRNAs could act as potential oncogenes and tumor repressors. Recent findings have demonstrated that miRNAs play critical roles in human gastric cancer.In this article,we reviewed the recent research progresses about the role of miRNAs in tumorigenesis,invasion and metastasis of gastric cancer and highlight the most significant and latest findings of original researches on potential implications of miRNA as a new class of biomarkers and therapeutic target in gastric cancer.

Neonatal stroke is one of the main causes of neonatal death and neurological sequalae. However,the therapeutic strategies for neonatal stroke have not been proven effective. Research advances of neonatal stroke including its incidence,clinical manifestation,neuroimaging are discussed in this review,and the diagnostic evaluation and managements to minimize the sequelae of neonatal stroke are also discussed.

Objective To investigate the clinical efficacy of hydrochlorothiazide combined with captopril and simvastatin in the treatment of elderly patients with hypertension and hyperlipidemia.Methods 50 elderly patients with hypertension and hyperlipidemia were randomly divided into two groups.The control group(25 cases) was given hydrochlorothiazide combined with captopril,the study group (25 cases) was given simvastatin on the basis of the control group.The blood pressure,changes in blood lipid levels and cerebrovascular events in 12 months were compared between the two groups.Results The blood pressure was declined in two groups,there was no significant difference (t =1.13,1.32,1.43,1.31,1.23,1.24,1.42,all P ＞ 0.05).After treatment,blood lipid levels of the study group significantly improved compared with before treatment (t =10.56,8.34,11.35,9.34,12.78,9.35,13.54,10.95,all P ＜ 0.05).The incidence rate of cerebrovascular events in 12 months of the study group was 12.0％,which was significantly lower than 28.0％ of the control group (x2 =8.45,P ＜ 0.05).Conclusion The elderly patients with hypertension and hyperlipidemia given antihypertensive and lipid lowering therapy can significantly reduce the incidence rate of long-term cardiovascular and cerebrovascular event,which is worth to be promoted in clinical.

Objective To explore the clinical effect of agar alginate combined impression preparation of a fLxed partial denture impressions.Methods 88 cases of patients with fixed partial dentures were divided into experimental group(group A) and control group(group B).Group A of 45 patients with 93 abutments,the legal system to take an impression of agar and alginate combined impression; group B of 43 patients with 80 base,the use of alginate impression preparation of an impression.Were observed with a magnifying glass impression of the type and number of records the number of abutments,impression defects.Results 63(67.8％) of group A were ideal,30(32.2％) had defects,33(41.2％) of group B were ideal,47(58.8％) had defects,there were significant differences(x2 =19.36,19.28,all P ＜ 0.05).At the cervical margin of bubbles,the gingival sulcus and shoulder were not clear,there was significant difference(x2 =10.46,11.25,all P ＜ 0.05).There were no significant difference in tear or defect of the neck at the edge of the two impression.Conclusion Agar and alginate impression of the legal systemcan take an impression of reduced defects,which is worthy of clinical application

Objective To examine whether the revised two-factor Study Process Questionnaire (SPQ-R-2) accords with four-factor model or two-dimension model in Chinese college students' learning situation. Methods Questionnaire survey was used and 1029 college students from three universities participated in the investigation were assessed with the Chinese version of (SPQ-R-2). Then correlation analysis and exploratory and Confirmatory factor analysis were conducted. Results The α coefficients of SPQ-R-2 ranged from 0.539 to 0.767. The correlation coefficients of inter-dimension ranged from -0.137 to -0.200,and the correlation coefficients of intra-dimension ranged from 0.557 to 0.918. Exploratory factor analysis using 515 samples showed SPQ-R-2 Chinese vision had four factors which could explain 45.023% variance and the loading of factors varied from 0.431 to 0.761.Confirmatory factor analysis using 514 samples indicated that the four-factor model and two-dimension model were the most fit models (χ2/df<5,RMSEA<0.08,ECVI value of approximately 1,AGFI value of approximately 0.90). Conclusion The SPQ-R-2 show good reliability and constructive validity. Four-factor model and two-dimension model have been proved free in China. The SPQ-R-2 is a reliable and valid measurement for assessing the study process of the Chinese college students.

Crohn's disease (CD) is a major involvement terminal ileum and proximal colonic inflammatory bowel disease(IBD),by now it still cannot be cured.The main symptoms include abdominal pain,diarrhea,fever.With the progress of the disease,it can exhibit rectal bleeding,intestinal fistula intestinal obstruction,etc.Children with CD can display growth retardation and delayed puberty.The treatment of CD has been a hot spot that is being discussed by clinicians.The drug treatment has many side effects.The surgery has high recurrence rates and some complications.Enteral nutrition (EN) is a nuuitional way that we can mnsport nutriment into stomach or small intestine through oral or tube with few side effects.It can improve the poor nutrition of the patients,induction and maintenance conditions.EN has been widely used in clinical treatment of CD,especially in paediatric CD.This paper summarizes the importance of EN in treatment of CD,the main function,mechanisms,therapy and the factors of curative effect.

ObjectiveTo observe the clinical efficacy of paired needling plus tuina in treating small breast disease.MethodBy following the randomized controlled method, 60 patients with small breast disease were divided into a treatment group (intervened by paired needling plus tuina) of 30 cases and a control group (intervened by treatment device for mammary glands) of 30 cases, 15 sessions as a treatment course, for 2 courses in total. The chest circumference was used to evaluate the therapeutic efficacy.Result There was no significant inter-group difference in comparing the chest circumference after the first treatment course(P>0.05), while the difference was statistically significant after 2 treatment courses(P<0.05).ConclusionPaired needling plus seven-step tuina can produce a significant stable long-standing therapeutic efficacy in treating small breast disease.

The effects of 1,25-dihydroxyvitamin D_3 on PHA-and alloantigen-induced human peripher-al blood lymphocyte proliferation,expressions of IL-2R and TfR were investigated by ~3H-TdRincorporation and indirect immunofluorescence methods respectively,The results demonstratedthat 1,25— (OH)_2D_3 had an inhibitory effect on PHA-induced proliferation (IC_(50)=19.1nM),which could partially reversed by exogenous recombinant IL-2,1,25 (OH)_3D_3 at high doses(10-100nM) it had an inhibitory effect.In both PHA-stimulated and alloactivated lymphocytes1,25(OH)_2D_3 could inhibit the expression of TfR and had no effect on that of IL-2R.This studysuggests that 1,25 (OH)_2D_3 in an important immunoregulatory hormone,the properties of whichneed further clarification.