Objective To discuss the pressure level of nurses in Shenzhen special administrative region (SAR) and its influencing factors and adopt selective psychological intervention to alleviate their working pressure,increase working efficiency and nursing quality. Methods The investigation by questionnaires was carried out by reference of working stress scale in 250 nurses and the results were analyzed.Results The main sources of working pressure include being afraid of making mistakes during work,frquent shift-work, low wages and other benefits,the character and social status of nursing work,less chances of advanced study and continuing education,lower recognition by patients,family and society.The working pressure was different in nurses with different position,time length of nursing work and education background. Conclusion Great working pressure existed in nurses in Shenzhen special administrative region(SAR).It is suggested that the management department should lessen or eliminate nurses'working pressure sourcs.Besides, they should practice measures to alleviate nurses'working pressure according to selective conditions.

Objective To explore the changes of Th1/Th2 cytokine in patients with Graves disease(GD) and the regulation effect of Shengmai Injection on its balance.Methods The patients with GD were randomly divided into 2 groups,the Shengmai treated group and the Methimazole treated group,30 cases per group and 30 healthy subjects were enrolled in this study.The serum concentrations of their Th1 cytokine(IFN-?) and Th2 cytokine(IL-10) were assayed by ELISA before and after treatment.Results The serum levels of INF-? and IL-10 in patients with GD were significant higher and the ratio of INF-?/IL-10 were significant lower than healthy subjects(P

Aim To study the effect of Bay k8644 on cardiac function with the model of myocardial ischemia-reperfusion injury(MIRI)in Rats.Methods Rat MIRI was induced by occluding the left anterior descending coronary artery for 40 min followed by 90 min reperfusion.Eighteen rats were divided randomly into 3 groups: saline,Bay k8644 and 0.1% dimethyl sulfoxide(DMSO)intravenously injected 30 min after ischemia.Heart functions were assessed before ischemia and 5,20 and 40 min after initiation of ischemia and 5,30,60 and 90 min after reperfusion,by measuring heart rate(HR),the left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP) and ?dp/dt_(max).Results After ischemia,LVSP and +dp/dt_(max) decreased(P

Objective To study the antioxidant effects of casein peptides with different molecular weights on liver tissue in mice.Methods Forty-eight mice were divided into four groups,and fed ig casein peptides in different molecular weights,3ku and distilled water as control.Results Casein peptides could improve the antioxidation ability of the mice,as to increase glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities of liver tissue,and reduce malondialdehyde (MDA).The antioxidant enzymes activities after giving casein peptides for 30d and 15d were significantly different.Conclusions Casein peptides can enhance the antioxidation of the mice and especially more effect with the molecular weight

Objective To study the association between metastatic ratio of lymph node and clinical pathological features and its prognosis in elderly patients with gastric cancer.Methods The first postoperative pathological data of 219 patients with gastric cancer aged ≥ 60 years were retrospectively analyzed.The relationships of metastatic ratio of lymph node with gender,differentiation degree,depth of tumor invasion,vascular invasion,perineural invasion were analyzed.We used Kaplan-Meier survival analysis and Cox regression model to analyze this relationship.Results The metastasis rate of lymph node was higher in gastric cancer patients with higher degree of differentiation,deeper tumor-infiltration,vascular invasion or neural invasion,and the metastasis rate of lymph node was increased in females than in males (all P＜0.05).Kaplan-Meier survival analysis and Cox regression model analysis suggested that the metastasis rate of lymph node was an independent factor for postoperative survival rate in the elderly with gastric cancer.Conclusions The metastatic ratio of lymph node could be used to estimate the clinical prognosis of elderly gastric cancer.

In view of the lack of health resources and medical treatment in Cangzhou City,especially at grass-roots level,Cangzhou medical college innovated the training mode for clinical medical students and actively explored the cooperation between school and hospital in the educational practice in an aim to improve the quality of talent training and to cultivate high-leveled specialized talents willing to stay in hospitals at grass-roots level and be useful.

Pulse wave velocity (PWV) is one of typical indicators to evaluate arterial stiffness.About the gender difference of pulse wave velocity,some controversies exist.In this paper,several factors affecting the differences such as height,aging,sex steroids,which affect the arterial structure and function and bring the gender difference,are reviewed relatively in detail.In addition,several aspects including measurement accuracy,analyzing method and the characteristics of sample population,which may induce the difference of PWV results,are also briefly reviewed.Meanwhile,some existing controversies are indicated objectively to further possible research interests in this field.

Objective To investigate the efficacy and security of tirofiban with low-dose heparin for treating progressing stroke with intracranial vessel stenosis,to analyze the clinical value of tirofiban in the treatment of ischemic stroke.Methods Clinical data of 26 patients treated with tirofiban and low-dose heparin for progressing stroke were retrospectively collected with NIHSS increment ≥3 within 6 days of stroke as the diagnosis standard.The degree of intracranial vessel stenosis was checked by CT angiography (CTA).The efficacy of tirofiban for treating progressing stroke,and the correlation between the degree of intracranial vessel stenosis and the prognosis of progressing stroke were observed.Results The percentage of progressing stroke patients with intracranial vessel stenosis/lesion was higher than without intracranial vessel stenosis/lesion (88.5 ％vs.11.5％,x2=14.786,P 0.000).There was a significant difference in NIHSS scores between progressing stroke patients with and without intracranial vessel stenosis/lesion before treatment (t 2.17,P=0.046).NIHSS scores were significantly decreased (t=3.59,P=0.021) in both two groups after treatment.MRS was lower in progressing stroke patients without intracranial vessel stenosis/lesion than in progressing stroke patients with intracranial vessel stenosis/lesion after treatment (t=6.79,P=0.001).The efficacy of tirofiban was higher in progressing stroke patients without intracranial vessel stenosis/lesion than in progressing stroke patients with intracranial vessel stenosis/lesion (60.2％ vs.30.8％,x2=4.35,P＜0.05).Conclusions Combination of tirofiban with low-dose heparin is safe and effective in the treatment of progressing stroke.The degree of intracranial vessel stenosis is correalted with progressing stroke prognosis.

Objective To discuss the causations and nursing points of blood vessel complications of patients after percutaneons coronary intervention (PCI). Methods 2546 CHD patients underwent PCI during January 2005 to February 2008. We analyzed the cases with blood vessel complications, and dis-cussed nursing points of these patients. Results There were 99 cases with blood vessel complications. All patients recovered except one who died of ventricular fibrillation after cardiac tamponade. Conclu- sions The causations of blood vessel complications after PCI are complex. Proficient skills, nursing before operations, confirmation of the state of the patients in time, effective treatment combined with careful nurs-ing are all important to prevent these complications.

AIM To examine antithrombotic effects of arecoline on the arterial thrombosis induced by carrageenin in mice through modulating the functions of endothelium and determine its mechanisms from hemostatic system, the platelet aggregative functions and the bioactive factors released by vascular endothelial cells. METHODS Kappa carrageenin was given ip in mice and mice were fed at the temperature of 20 to 21 degrees and at the humidity of 30 percent to 50 percent. RESULTS On the foregoing models of thrombosis, arecoline could antagonize the formation of thrombosis through activating the endothelial target for acetylcholine in a dose dependent manner and its antithrombotic potency was 250 to 500 times greater than aspirin; while under the same conditions, pilocarpine could not antagonize the formation of thrombosis. The levels of TT, PT, KPTT and MAR had no prominent changes compaired with control groups. The levels of t-PA became higher greatly than normal and the levels of PAI 1 became lower greatly than normal 2 hours after intravenous injection of arecoline in rats. Arecoline could decrease the higher plasma levels of thromboxane A2 and increase the lower plasma levels of prostacyclin in a dose dependent manner in the mice tail thrombosis induced by carrageenin. CONCLUSION The antithrombotic effects of arecoline are associated with activating the endothelial target for acetylcholine closely, but are not associated with muscarinic receptors,and not relevant to hemostatic systems or functions of platelet aggregation directly.