Introduction: None of the identified studies employed quantitative scales correlating the knowledge and attitudes toward epilepsy. Method: This study aimed to study the relationship between the knowledge and attitudes toward epilepsy, using the Epilepsy Knowledge Questionnaire (EKQ) and the Public Attitudes Toward Epilepsy (PATE) scale. Results: A total of 279 publics with a mean age of 36.6±14.7 years (ranged from 15-77 years), 50.8% female with majority (63.0%) Chinese, and 49.5% with tertiary education level, were recruited. The mean score of epilepsy knowledge questionnaire (EKQ) was 21.05±3.92 (95% CI: 20.57-21.48). Higher score in EKQ was associated with higher education level (p<0.01). The total score in the EKQ correlated negatively with the mean scores in the PATE scale, as well as the mean scores in both the personal domain and general domains in the PATE scale (p<0.05). Only 8 out of 34 items in EKQ were associated significantly with the mean scores in the personal domain, and 4 other items were with the general domain of the PATE scale. Conclusion: This study showed that although the overall knowledge in epilepsy is significantly associated with better attitudes toward epilepsy, only certain aspects of knowledge in the scale contributed to this association.