This study probes into the prospect of cross-reactivity of HCMV with RCMV which
has not been acknowledged to date. We describe the uncovering of a protein with an estimated
size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera.
Our findings are a first disclosure of a plausible immunological cross-reactivity between
RCMV with its human counterpart which grounds substantial interest implying existence of
conserved determinants between rat and human CMV polypeptides. The cross-reactive protein
most likely represents an enveloped glycoprotein, though the precise identification and its
degree of similarity needs to be evidently defined and further elucidated in forthcoming
experiments.
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