1.Dengue protease inhibition activity of selected Malaysian medicinal herbs
Salleh, H.M. ; Chong, S.-L. ; Othman, R. ; Hazni, H. ; Ahmad, K. ; Mohd Yusof, M.Y.Z. ; Fauzi, N.W. ; Wahab, H.A. ; Liew, S.Y. ; Awang, K.
Tropical Biomedicine 2019;36(2):357-366
Dengue fever is one of major health problem around the world including Malaysia.
It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes
aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes
(DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various
Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops
aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited
potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of
Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 μg/mL with
IC50 value of 0.30 ± 0.16 μg/mL.
Result Analysis
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