1.Sensitivity and Specificity of Vestibular Evoked Myogenic Potential Elicited By Different Tone Bursts to Diagnose Peripheral Vestibular Disordered
Zuraida Zainun ; Mohd Normani Zakaria ; Din Suhaimi Sidek ; Zalina Ismail
Malaysian Journal of Medicine and Health Sciences 2014;10(2):9-17
Peripheral vestibular disorder (PVD) is serious and common. Clinically, giving an accurate diagnosis of
PVD can be challenging. Vestibular evoked myogenic potential (VEMP) is an objective test to evaluate
the integrity of vestibular organs, particularly saccule and/or inferior vestibular nerve. This study was
performed to determine the sensitivity and specificity of VEMP using different stimuli. Fourty normal
and 65 PVD subjects who fulfilled the inclusion criteria were recruited. While sitting comfortably,
VEMP waveforms were recorded with active electrode on sternocleidomastoid muscle and negative
electrode on upper forehead. Tone bursts (500, 750 and 1000 Hz) were delivered via headphones at 90
dBnHL and 5/s presentation rate. VEMP parameters for each stimulus (amplitude and latency of P1
and N1 peak) were analyzed accordingly. Receiver operating characteristic (ROC) was performed to
determine the sensitivity and specificity of VEMP at different test frequencies. N1 amplitude of 750 Hz
stimulus produced the most ideal sensitivity (65% on right and 63% on left) and specificity (83% on
right and 78% on left). The importance of using a few tone bursts in VEMP test in order to minimize the
false negative in cases might be encountered in clinics as the certain tone burst had inadequate sensitivity
in detecting PVD cases. The 750 Hz stimulus produced the most ideal VEMP with adequate values of
sensitivity and specificity, at least in this study.
Vestibulocochlear Nerve Diseases
2.Clinical use of Malay Version of Vertigo Symptom Scale (MVVSS) in Patients with Peripheral Vestibular Disorder (PVD)
Zuraida Zainun ; Mohd Normani Zakaria ; Dinsuhaimi Sidek ; Zalina Ismail
The Medical Journal of Malaysia 2012;67(4):386-389
Introduction:The Vertigo symptom scale (VSS) is a well
established tool for the evaluation of vestibular disorders
and the associated symptoms of autonomic arousal and
somatosensation. By using a validated Malay version of
vertigo symptom scale (MVVSS) questionnaire, the severity
of the vertigo from patients’ perspective can be determined
and rated. Before MVVSS can be applied clinically among
Malaysians, it was of interest to determine its clinical value in identifying vestibular disorders.
Method: Forty normal and 65 PVD subjects participated in
this cross-sectional study. Normal subjects were recruited
amongst Universiti Sains Malaysia (USM) staff and students
who had no history of ear and vestibular disorders.
Results: Mean total score of MVVSS in normal and PVD
subjects were 13.9 ± 11.1 and 30.1 ± 20.9, respectively. When the total scores of normal and PVD group were compared, the Mann-Whitney U test showed that there was a
significant difference between the two groups (p<0.05). This is consistent with previous studies. It was also of interest to see if subtypes of PVD [benign paroxymal positional vertigo (BPPV), Meniere’s disease, labyrinthitis and unknown] have different MVVSS results. However, analysis of variance (ANOVA) found no significant difference in term of outcomes of MVVSS among the different PVD pathologies. Using receiver operating characteristic curve (ROC) method, the
sensitivity and specificity of MVVSS were 71% and 60%,
respectively.
Conclusion: MVVSS is able to discriminate clinically among
the normal and PVD subjects. However, it is not a good
indicator for differential diagnosis of PVD subtypes, at least in this study. Its sensitivity and specificity in clinical diagnosis are reasonably high. Perhaps a bigger sample size would be useful to further study the clinical usefulness of MVVSS.
3.The effectiveness of psychological interventions amongtinnitus sufferers: A review
Wan Suhailah Wan Husain ; Mohd Normani Zakaria ; Nik Adilah Nik Othman ; Azizah Othman ; Aw Cheu Lih ; Zuraida Zainun
The Medical Journal of Malaysia 2015;70(3):188-197
SUMMARY
Introduction: The aim of this article was to review the types
of psychological interventions for patients with tinnitus,
professionals involved in giving the intervention, the
effectiveness of each method of interventions and
comparisons with non-psychological approaches in treating
tinnitus.
Materials and Methods: PubMed database searched.
Results: Twenty one articles that employed randomized
controlled trials design were included. Cognitive
behavioural therapy (CBT) was the most common
intervention conducted by the researchers. Clinical
psychologists and trainee psychologists were the most
professionals involved in the therapy. The length of therapy
ranged from six weeks to three months.
Discussion: Psychological interventions were more
effective in reducing psychological impacts of tinnitus than
non-psychological interventions such as the use of tinnitus
maskers. Nevertheless, the combination of the treatments
yielded more superior outcomes.
Conclusion: A simplified version of psychological
intervention that can be implemented by other clinical
professionals should be developed to treat tinnitus
holistically to overcome the shortage number of clinical
psychologists.
Tinnitus
;
Clinical Trial
4.The Test-Retest Reliability of Subjective Visual Horizontal Testing:Comparisons between Solid and Dotted Line Images
Mohd Normani ZAKARIA ; Nor Haniza Abdul WAHAT ; Zuraida ZAINUN ; Nurul Syarida Mohd SAKERI ; Rosdan SALIM
Journal of Audiology & Otology 2020;24(2):107-111
The present study aimed to determine the test-retest reliability of subjective visual horizontal(SVH) testing when tested with solid and dotted line images. In this repeated measures study,36 healthy young Malaysian adults (mean age=23.3±2.3 years, 17 males and 19 females)were enrolled. All of them were healthy and had no hearing, vestibular, balance, or vision problems.The SVH angles were recorded from each participant in an upright body position using acomputerized device. They were asked to report their horizontality perception for solid and dottedline images (in the presence of a static black background). After 1 week, the SVH procedurewas repeated. The test-retest reliability of SVH was found to be good for both solid line[intraclass correlation (ICC)=0.80] and dotted line (ICC=0.78). As revealed by Bland-Altmanplots, for each visual image, the agreements of SVH between the two sessions were within theclinically accepted criteria (±2°). The SVH testing was found to be temporally reliable, which canbe clinically beneficial. Both solid and dotted lines in the SVH testing are reliable to be usedamong young adults. J Audiol Otol 2020;24(2):107-111
5.The Dominance of Ossicular Route in Sound Transmission.
Mohd Normani ZAKARIA ; Aw Cheu LIH ; Noor Alaudin Abdul WAHAB
Clinical and Experimental Otorhinolaryngology 2016;9(3):282-283
No abstract available.
6.Listening to Sentences in Noise: Revealing Binaural Hearing Challenges in Patients with Schizophrenia.
Noor Alaudin ABDUL WAHAB ; Mohd Normani ZAKARIA ; Abdul Hamid ABDUL RAHMAN ; Dinsuhaimi SIDEK ; Suzaily WAHAB
Psychiatry Investigation 2017;14(6):786-794
OBJECTIVE: The present, case-control, study investigates binaural hearing performance in schizophrenia patients towards sentences presented in quiet and noise. METHODS: Participants were twenty-one healthy controls and sixteen schizophrenia patients with normal peripheral auditory functions. The binaural hearing was examined in four listening conditions by using the Malay version of hearing in noise test. The syntactically and semantically correct sentences were presented via headphones to the randomly selected subjects. In each condition, the adaptively obtained reception thresholds for speech (RTS) were used to determine RTS noise composite and spatial release from masking. RESULTS: Schizophrenia patients demonstrated significantly higher mean RTS value relative to healthy controls (p=0.018). The large effect size found in three listening conditions, i.e., in quiet (d=1.07), noise right (d=0.88) and noise composite (d=0.90) indicates statistically significant difference between the groups. However, noise front and noise left conditions show medium (d=0.61) and small (d=0.50) effect size respectively. No statistical difference between groups was noted in regards to spatial release from masking on right (p=0.305) and left (p=0.970) ear. CONCLUSION: The present findings suggest an abnormal unilateral auditory processing in central auditory pathway in schizophrenia patients. Future studies to explore the role of binaural and spatial auditory processing were recommended.
Auditory Pathways
;
Case-Control Studies
;
Ear
;
Hearing*
;
Humans
;
Masks
;
Noise*
;
Schizophrenia*
7.Tinnitus Severity and the Sound Therapy Outcome.
Mohd Normani ZAKARIA ; Nik Adilah NIK OTHMAN ; Aw CHEU LIH
Clinical and Experimental Otorhinolaryngology 2015;8(2):179-179
No abstract available.
Tinnitus*
8.The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study.
Noor Alaudin ABDUL WAHAB ; Suzaily WAHAB ; Abdul Hamid ABDUL RAHMAN ; Dinsuhaimi SIDEK ; Mohd Normani ZAKARIA
Psychiatry Investigation 2016;13(1):82-88
OBJECTIVE: Electrophysiological studies, which are mostly focused on afferent pathway, have proven that auditory processing deficits exist in patients with schizophrenia. Nevertheless, reports on the suppressive effect of efferent auditory pathway on cochlear outer hair cells among schizophrenia patients are limited. The present, case-control, study examined the contralateral suppression of transient evoked otoacoustic emissions (TEOAEs) in patients with schizophrenia. METHODS: Participants were twenty-three healthy controls and sixteen schizophrenia patients with normal hearing, middle ear and cochlear outer hair cells function. Absolute non-linear and linear TEOAEs were measured in both ears by delivering clicks stimuli at 80 dB SPL and 60 dB SPL respectively. Subsequently, contralateral suppression was determined by subtracting the absolute TEOAEs response obtained at 60 dBpe SPL during the absence and presence of contralateral white noise delivered at 65 dB HL. No attention tasks were conducted during measurements. RESULTS: We found no significant difference in absolute TEOAEs responses at 80 dB SPL, in either diagnosis or ear groups (p>0.05). However, the overall contralateral suppression was significantly larger in schizophrenia patients (p<0.05). Specifically, patients with schizophrenia demonstrated significantly increased right ear contralateral suppression compared to healthy control (p<0.05). CONCLUSION: The present findings suggest increased inhibitory effect of efferent auditory pathway especially on the right cochlear outer hair cells. Further studies to investigate increased suppressive effects are crucial to expand the current understanding of auditory hallucination mechanisms in schizophrenia patients.
Afferent Pathways
;
Auditory Pathways
;
Case-Control Studies
;
Diagnosis
;
Ear
;
Ear, Middle
;
Efferent Pathways
;
Hair
;
Hallucinations
;
Hearing
;
Humans
;
Noise
;
Schizophrenia*
9.Earlier Peak Latencies May Not Fully Reflect the Robustness of Cervical Vestibular Evoked Myogenic Potential to CE-Chirp Stimulus
Mohd Normani ZAKARIA ; Athar Mazen Rasmi ABDALLATIF ; Wan Najibah Wan MOHAMAD ; Rosdan SALIM ; Ahmad Aidil Arafat DZULKARNAIN
Journal of Audiology & Otology 2022;26(2):108-109
10.Auditory Localization Performances in Subjects with Simulated Unilateral Conductive Hearing Loss
Mohd Normani ZAKARIA ; Wan Najibah Wan MOHAMAD ; Noor Alaudin Abdul WAHAB ; Nashrah MAAMOR
Journal of Audiology & Otology 2019;23(2):118-119
No abstract available.
Hearing Loss, Conductive
;
Sound Localization