Introduction: Social media and Internet use during disasters have been proven to be useful tools in helping public health agencies to respond to pandemics. However, this tool can also be the culprit in the spread of misinformation to the public. This study aims to identify the public health impact of misinformation during the COVID-19 pandemic using the socio-ecological model. Methods: A systematic review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was initially undertaken by searching relevant articles published from January to November 2020 in several electronic databases including Medline, PubMed, and Springer link. All publications produced in English regarding the impact of misinformation during the COVID-19 outbreak were included except review articles. Results: Eleven articles were identified from these databases. The public health impact of misinformation from these articles was analysed and discussed according to the domains of the socio-ecological model. It was found that various elements of misinformation on the COVID-19 pandemic caused a significant impact on the individual, interpersonal, organisational, community, and policy levels across various nations. Conclusion: This study concludes that addressing misinformation during a pandemic such as the COVID-19 phenomenon is an important measure to improve public health response in mitigating the spread of pandemics.