The present study aimed to determine the factors associated with CKD stage 3b among type 2 diabetics attending primary care follow-up, specifically the role of angiotensin blockade dosage. This was a pilot unmatched case-control study conducted in a teaching primary care centre. Clinical data of 25 cases of diabetic patients with CKD stage 3b (GFR 30-45ml/min/1.73m2) in 2012 were selected for this study, as well as 103 controls who were diabetic patients with GFR more than 45ml/min/1.73m2 in 2012. Systematic random sampling was employed. Data was obtained from patients’ diabetic records, computerised clinical medical information system and medical case notes. Univariate analysis was done using Chi-square, t-test, Fisher’s exact test and Mann-Whitney U-test. Multiple logistic regression was used to determine the associated factors for development of CKD stage 3b. Cases and controls were different in terms of age, duration of diabetes, use and dosage of angiotensin blockade medications, systolic blood pressure and baseline GFR. Multiple logistic regression revealed that systolic blood pressure (Adjusted OR= 1.08, 95% CI= 1.02-1.14, p=0.013) and baseline GFR (Adjusted OR= 0.90, 95% CI= 0.85-0.95, p<0.001) was significantly associated with the development of CKD stage 3b among diabetics. Maximizing the dose of angiotensin blockade had a protective effect (Adjusted OR= 0.14, 95% CI=0.85-0.95, p=0.025). The results of the present study supports the need for good control of systolic blood pressure among diabetic patients to reduce the risk of chronic kidney disease progression. Dose of angiotensin blockade medications should be optimised in these patients.

Background: Those with increased dynamic knee valgus are vulnerable to increased risk of non-contact knee injuries. However, studies on the top down kinetic chain of lower limb mechanics during dynamic motions such as single leg squat (SLS) among trained males were scarce. Objective: The objective of the study was to evaluate the relationship between isokinetic hip and knee strength and frontal plane projection angle (FPPA) of the knee joint during SLS. Methods: Thirty-two male junior athletes (twelve cyclists, ten runners and ten squash players) were screened for excessive dynamic knee valgus (DKV) prior to participation. Only those within the normal value of DKV were included. Their hip and knee isokinetic strength in sagittal plane were evaluated at 60º/s of angular velocity for both legs using dynamometer. Two dimensional knee FPPA was evaluated during SLS at 60º of knee flexion. Pearson correlation was evaluated between knee FPPA during SLS and isokinetic leg strength. Results: Correlations between knee FPPA and hip and knee isokinetic strength were not statistically significant except between knee flexion peak torque/body weight (r = -0.35, p = 0.05) and hamstring to quadriceps ratio (r = -0.39, p = 0.03) of non-dominant leg. Conclusions:Isokinetic hip and knee strength and knee FPPA during SLS was correlated only for non-dominant leg during SLS among male junior athletes. DKV during SLS may be reduced through strengthening the muscles around hip and knee joints.