Background: Coronavirus illness (COVID-19) reached the level of a significant public health emergency in 2019, with an estimated worldwide death toll of more than 1,00,000 people 2019. Coronavirus illness (COVID-19). This survey was conducted to identify the factors influencing COVID-19 practice among undergraduate nursing students at the University of Nizwa, Sultanate of Oman. Methods: A quantitative cross-sectional online survey of sixty-four undergraduate nursing students chosen from the school of Nursing at the University of Nizwa in Sultanate of Oman took part from July 30 to August 5, 2021. Results: Participants’ average age was 22.27 ± 1.04, and the male-to-female ratio was 31.8% (n=64). Nursing students had adequate knowledge (13.67 ± 3.46), a positive attitude (48.14 ± 12.29), and good practices (32.6 ± 6.12), according to the results of a survey. Female students, compared to males (0.006, p<0.05), were more likely to follow better practices. Significant positive associations were found between age (0.025, p<0.05), gender (0.006, P<0.05), living areas (0.031, p<0.05), grade (0.000, p<0.05), Clinical practice experienced (0.016, p<0.05) and practice on COVID -19. Conclusions The study findings exhibited the essential elements that affected COVID-19 precautionary practices, knowledge, and a positive attitude, which were the most critical variables to consider. Male students and students who reside in rural regions should be targeted for further health education, and efforts should be made to ensure these groups have access to reliable and effective online tools to assist them.