1.Endocrinological Outcome of Endoscopic Transsphenoidal Surgery for Functioning and Non-Functioning Pituitary Adenoma
Lee Shwu Yi ; Azmi Alias ; Abdul Rahman Izaini Ghani ; Mohammad Badrulnizam Long Bidin
Malaysian Journal of Medical Sciences 2019;26(3):64-71
Introduction: The present study analysed the (i) remission and preservation of hormones,
(ii) endocrinological and anatomical complications and (iii) visual improvement after endoscopic
transsphenoidal surgery (ETS).
Methods: The retrospective observational study of all consecutive cases of pituitary
adenoma treated with ETS in Hospital Kuala Lumpur (HKL) between 2006 and 2015. Age, sex, preand
post-operative hormone level, tumour size, and complications were noted.
Results: A total of 67 patients were diagnosed with non-functioning pituitary adenoma
throughout this period. Of these, 11 patients had both visual and hormonal improvement postoperation.
Of the 27 patients with tumour invaded into the cavernous sinus, 13 showed an
improved vision. In the adenoma patients who had impaired hormonal function before the
surgery, the hormone level normalised post-surgery in 42 patients.
Moreover, 39 patients were diagnosed with functioning pituitary adenoma. Ten patients
recovered from acromegaly and four patients recovered from Cushing disease within seven days
post-operative. Also, five patients with functioning adenoma suffered complications.
Conclusion: Outcome for the preservation and hormone recovery in non-functioning
pituitary adenoma group was satisfactory, with only one patient’s hormonal level worsening.
No visual deterioration and mortality were detected throughout this study. A dedicated team
specialised in endoscopic transsphenoidal pituitary surgery further improved the outcome of this
surgical method.