The first novel coronavirus case was reported on December 2019, in Wuhan, China (Xu et al., 2020), named by WHO as SARS-CoV2 and the causing disease as coronavirus disease 2019 (COVID2019). The genome sequence revealed that the virus is belongs to the beta-coronavirus group, sharing ancestry with bat coronavirus HKU9-1, similar to SARS-coronaviruses.1 The number of cases has increased within few weeks, and later spread beyond the China border.2 The epidemic of COVID-19 began in Africa later than other regions globally, perhaps, because of the limited international air traffic, rather than the climate conditions. In Africa, the first cases were reported in early March 2020 in Egypt, followed by Algeria, and Sudan.3 Sudan is located in the north-eastern Africa it occupies 1.882.000 million km square, making it third-largest country in Africa, and 16th in the world, with a population of over 40 million people.4 and Khartoum is the capital which is the main international air travel hub. Khartoum is considered the epi centre of majority of reported and imported COVID-19 cases. In this letter we describe the impact of COVID 19 in Sudan; highlighting the response towards COVID-19 pandemic and the challenges towards possible control and prevention the outbreak