CNS malignant astrocytoma has a descending frequency of occurrence according to site; moving from intracranial to cervical-medullary, thoracic, lumbar and extremely rare in the conus medullaris. IMSC glioblastoma are rare and de novo conus medullaris GBM is an extreme rarity. The duration of symptoms is short and the neurological & clinical deterioration are rapid. Despite aggressive treatment via surgery and radiotherapy IMSC & conus GBM still carry a grim and fatal prognosis. This is a strong motivation for developing new treatment strategy. New treatment modality like Temozolomide & gene therapy is currently in under studyand long term result is under study and review.