1.Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test (CD-DST) for a Leiomyosarcoma Originating in the Inferior Vena Cava
Nobuo Kondo ; Masaki Yamamoto ; Hideaki Nishimori ; Takashi Fukutomi ; Seiichiro Wariishi ; Kazuki Kihara ; Miwa Tashiro ; Kazumasa Orihashi
Japanese Journal of Cardiovascular Surgery 2013;42(2):124-127
The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) identifies effective anticancer drug using resected tumor specimen, enabling tailor-made chemotherapy for a rare tumor. We report a case of the patient with leiomyosarcoma originating in the inferior vena cava, to which CD-DST was applied. This application has not been previously reported to the best of our knowledge. A 61-year-old woman consulted a nearby hospital because of abdominal pain. Computed tomography revealed an inferior vena cava tumor. The tumor was resected with the inferior vena cava, which was reconstructed with a 16 mm ePTFE graft. The tumor was diagnosed as leiomyosarcoma histopathologically. CDDP, VP-16, ADR, and VDS were CD-DST showed the tumor to be sensitive. Her postoperative course has been good without recurrence of tumor for 6 months, and the results of CD-DST may be helpful for chemotherapy strategy in case of recurrence.
2.Descending Aortic Replacement for Pseudoaneurysm Following Total Arch Replacement with Proximal Endoclamping Using an Occlusion Balloon
Nobuyuki HIROSE ; Hideaki NISHIMORI ; Takashi FUKUTOMI ; Masaki YAMAMOTO ; Kazuki KIHARA ; Miwa TASHIRO ; Kazumasa ORIHASHI
Japanese Journal of Cardiovascular Surgery 2018;47(4):187-191
An 83-year-old man who had undergone aortic arch repair using the elephant trunk technique in addition to abdominal aorta repair required surgical intervention for a pseudoaneurysm at the distal anastomosis of the aortic arch graft. Due to marked adhesion around the aneurysm, aortic cross-clamping was not feasible. Thus, under femoro-femoral partial bypass, the arch prosthesis was endoclamped using an aortic occlusion balloon inserted through the left femoral artery into the aortic arch graft and through the elephant trunk, guided by fluoroscopy and transesophageal echocardiography. This allowed descending aorta replacement with minimal bleeding. His postoperative course was uneventful. This technique enabled safe and bloodless clamping of the proximal portion of the aortic arch graft.