A 70-year-old man was admitted to our hospital because of cough and dyspnea. On the 7th hospital day, he suddenly suffered by severe pulmonary congestion and bilateral pleural effusion with a prominent heart murmur. After improvement of the symptoms, 3-D CT scan and cardiac catheterization confirmed patent ductal aneurysm of about 10.5cm in diameter. Because of pulmonary hemorrhage, an emergency operation was performed using a left thoracotomy approach. A large aneurysmal mass of about 12cm in diameter was transected and the pulmonary end and aortic end of the ductus arteriosus were closed using a patch under partial cardiopulmonary bypass. His postoperative course was uneventful and he was discharged on the 27th day after operation.

Patients with chronic liver diseases who were hospitalized into our clinic were studied. Chronic liver diseases consisted of three groups, namely chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Patients with peptic ulcer were studied as a control group. The mean age was the difference of 8.4 years between a group of chronic hepatitis and that of liver cirrhosis, but only 3.0 years between a group of liver cirrhosis and that of hepatocellular carcinoma. HBs antigen positive ratio was almostly same between a group of chronic hepatitis and that of liver cirrhosis, but about twice in a group of hepatocellular carcinoma. Ratio of hard drinker was lowest in a group of hepatocellular carcinoma, and therefore we considered that the effects of alcohol upon carcinogenesis were little. HBs antibody positive ratio was no difference among groups of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma.

Patients with fatty liver diagnosed by computed tomography (CT) were studied clinically. Diagnostic criteria of fatty liver by CT was that the ratio of CT value of the liver to that of the spleen was less than 0.90. In cases of fatty liver, hepatic volume was significantly more increased (p<0.01) than normal controls, but volume of the spleen was not more increased. Fatty liver was diagnosed by CT in thirty eight cases. These cases were divided into four groups according to causes of fatty liver.The first was obesity group (fifteen cases), the second was alcohol group (fourteen cases), the third was DM group (four cases) and the fourth was group of unknown origin (five cases). Values of GOT/GPT (OP ratio), γ-GTP, CHE, LAP and ALB were significantly different (p<0.01) between obesity and alcohol group. Many cases of obesity group showed hypercholinesterasemia, but in many cases of alcohol group values of cholinesterase were lower than normal range.

Liver function influenced by drinking were studied in cases of a thorough physical examination. Objects of our study were 172 cases who entered in our clinic during past two years. 172 cases were divided into three groups. 1st group was 70 cases who had drunk less than 20 grams of ethyl alcohol a day, 2nd group was 49 cases who had drunk 20 grams a day and 3rd group was 53 cases who had drunk 40 grams a day.
GOT, GOT/GPT, γ-GTP, CHE and LAP were changed significantly with the increase of drinking as a result of study of these three groups. Especially it was thought that GOT/GPT, γ-GTP and LAP reflected most sharply the grade of alcoholic liver injury.

To evaluate the association of serum BDNF concentration with high-intensity interval training, 12 healthy male volunteers, aged 28-48 years, completed 16-week high-intensity interval training (HIIT) using ergometer. Training program consisted of >90% VO₂ peak for 60 sec separated by 60 sec active rest period for 8-12 sets twice weekly for 16-week. Maximal exercise tolerance tests were performed before (0-week), 4-week, and 16-week after the intervention program. VO₂ peak as well as peak watt was linearly increased after 4-week (9% for both VO₂ peak and peak watt) and 16-week HIIT training (15% for VO₂ peak and 18% for peak watt, p<0.01). However, there was no change in serum BDNF concentration by HIIT. On the other hand, there was a positive association of serum BDNF concentration at baseline with % increase in peak watt after the intervention (ρ=0.60, p<0.05). The association between BDNF and exercise training is still unclear, and more studies are needed to clarify the above positive association.