Objective To investigate the association between the polymorphism of CYP17 gene and the risk of prostate cancer. Methods A case control study including 125 prostate cancer patients and 158 age matched controls was conducted.The polymorphism was investigated by PCR using DNA from peripheral blood lymphocytes. The transition (T→C) in the risk allele (A2) produced a new recognition site for the restriction enzyme MspA1.Three genotypes of CYP17 gene (A1/A1,A1/A2,A2/A2) were determined and confirmed by sequencing. Results The frequency of the A2 allele was similar in the cases and controls.Compared with men with A1/A1 genotype, the odds ratios were 1.19 and 1.28 for the A1/A2 and A2/A2 genotypes,respectively.However,stratification by age of prostate cancer cases revealed that among prostate cancer cases older than 69 years,the odds ratio was 3.97 and 3.21 for the A1/A2 and A2/A2 genotypes ( P =0.007,0.023,respectively).Meanwhile,comparison among 3 subgroups (division by genotypes) of controls,the fPSA and tPSA levels were not significantly different. Conclusions These results indicate that A2 allele does not increase the risk of prostate cancer in Chinese. But in men older than 69 years,A1/A2 and A2/A2 genotypes predict susceptibility to prostate cancer. It is suggested that CYP17 gene may be associated with the morbidity of prostate cancer in elderly male population.

OBJECTIVESTo investigate the correlation between corpus cavernosum disruption and high-flow priapism for the understanding of high-flow priapism and its treatment.

METHODSTo report the clinical data of a case of spontaneous idiopathic high-flow priapism.

RESULTSThe diagnosis was made as right cavernosal artery disruption after angiography. The result of cavernosal blood gas analysis was normal. The penis became detumescent after the gelatin embolization treatment was performed.

CONCLUSIONSSpontaneous high-flow priapism of old people(non-ischemic) is rare in clinic. Blood gas analysis and angiography are needed to find the hemorrhage site when conservative treatment fails. Gelatin embolization or cavernosal artery ligation are usually effective in the subsequent treatment.

Angiography ; Blood Gas Analysis ; Embolization, Therapeutic ; Humans ; Male ; Middle Aged ; Penis ; blood supply ; Priapism ; diagnosis ; therapy ; Regional Blood Flow

ObjectiveTo explore an appropriate way and its effect on neonatal resuscitation training in Uygur area of Xinjiang, China.MethodsFrom October 2014 to February 2015, obstetricians, neonatologists (pediatricians), midwives and anesthetists from Turpan Region Central Hospital, Turpan City People's Hospital,Aksu Region First People's Hospital and other five hospitals at county level were chosen to attend the training course of neonatal resuscitation. The textbook for the course was Guidelines for Resuscitation which had been translated to Uygur language from English and the class was lead by less than ten Uygur trainees with Mandarin and Uygur when necessary in addressing some difficult or important points. The duration of theoretic courses took 6 h and the operational course took 8 h. Theorectical exam was taken before, immediately after and three months after (before re-training) the training. The accuracy rate was applied to assess the effect of training through evaluation for each resuscitation techniques. Repeated measures analysis of variance andChi-square test were used for statistical analysis.ResultsA total of 220 health care staff were included in the study. The average score of theoretical examination after the training was higher than that before (85.68±8.52 vs 65.37±12.08,t=18.532,P=0.000), and that before re-training was lower than that after training (80.08±12.70 vs 85.68±8.52,t=-4.943,P=0.000). After the training, the proportions of Done in each item, including rapid assessment, preliminary resuscitation, correct positive pressure artificial ventilation, external cardiac massage together with artificial ventilation, proper endotracheal intubation and proper administration of resuscitation drugs, were all higher that those before [72.7%(160/220) vs 1.4%(3/220), 40.0%(88/220) vs 0%(0/220), 15.9%(35/220) vs 0%(0/220), 37.7%(83/220) vs 8.2%(18/220), 51.8%(114/220) vs 5.9%(13/220) and 48.2%(106/220) vs 10.5%(23/220), allP<0.01]. But at the time before re-training, only one proportion ofDone which was higher than those immediately after initial training was proper administration of resuscitation drugs [49.6%(109/220) vs 48.2%(106/220),χ2=9.129,P<0.05].ConclusionBilingual (Mandarin and Uygur) neonatal resuscitation training in Xinjiang minority areas might enhance the recovery skills for local medical personnel.