Objective To study the effect of aloe gel on the wound healing rate and the expression of epidermal growth factor(EGF) and basic fibroblast growth factor(bFGF) of radiative dermatitis erythematase in rats.Methods The rat models of radiative dermatitis erythematase(vesicular reaction) were established.With the normal healing group as the control group,aloe gel was used on the radiative dermatitis erythematase of rats in the experimental group.At the 2,6,10,18 and 24d postinjury,the protein of EGF and bFGF were stained immunohistochemically and analysed;the wound healing rate was also measured.Results ① The wound healing rate: the wound healing rate of experiment groups was significantly higher than that of the control group at 10th day and 18th day(P

Background and purpose:To date, it mainly depended on imaging examination for detection of residual lesions, recurrence and distant metastasis, evaluation the sensitivity of radiotherapy and chemotherapy, and prognosis in nasopharyngeal carcinoma (NPC). Thus, searching for new tumor markers for NPC early diagnosis and individualized treatment is still merited. This study was aimed to investigate the expressions of serum macrophage inflammatory protein (MIP)-3α and cystatin A in patients with NPC before and after treatment, and to explore two markers’ value in NPC diagnosis, clinicopathological characteristics and clinical outcome assessment. Methods:The serum levels of MIP-3αand cystatin A in 140 primary NPC patients without distant metastasis before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA) and compared with those in 100 healthy controls. Results:The sensitivity of MIP-3αand cystatin A were 92.1%and 42.1%, respectively;and the specificity of MIP-3αand cystatin A were 86.0%and 85.0%, respectively. All 140 NPC patients had complete remission (CR) or partial remission (PR). Serum levels of MIP-3αand cystatin A in pre-treatment patients with NPC were higher than those in post-treatment patients and controls. Serum MIP-3αand cystatin A levels were associated with overall stage of NPC, and MIP-3αwas also associated with T classification of NPC. The serum MIP-3αlevel in NPC with CR after treatment reduced to the level in control group, and that was still significantly higher in NPC with PR than in control group. No significant difference was found in the serum cystatin A level between NPC with CR or PR after treatment and control group. During 1-year follow-up, the post-treatment serum levels of MIP-3αand cystatin A were significantly higher in patients with distant metastasis than in patients without distant metastasis and controls. There was found statistically significant correlation between MIP-3α and cystatin A.Conclusion:MIP-3α may be a potential marker of NPC serological diagnosis. The detection of serum MIP-3αand cystatin A may contribute to the NPC staging and prediction of short-term clinical outcomes.

OBJECTIVE: To analyze and compare different methods for assessment of the limbs joints function and to discuss the rationality of the methods. METHODS: Eight hundred and six cases were collected from the Fujian Minzhong Forensic Appraisal Center from 2007 to 2010. These cases included injuries of large limbs joints with or without peripheral nerve injury. The loss of joint function was calculated according to the simple joint mobility method or the table method introduced in the book "Forensic Clinical Judicial Authentication Practice". The results of disability evaluation with different methods were analyzed and compared between different joints and injury patterns. RESULTS: In 642 cases of simple joint injuries without peripheral nerve injury, the results of disability evaluation based on simple joint mobility were the same as that based on the table. In 118 cases of joint injuries with peripheral nerve injury, all of them could be classified as disability, 33 cases (28.00%) had higher degree based on the table method than based on the simple joint mobility method. While 21 cases (17.80%) did not be evaluated as disabled based on the simple joint mobility method. CONCLUSION The evaluation for loss of limb function would be easier, more scientific and reasonable by the direct table method than the simple joint mobility method.
Accidents, Traffic ; Adult ; Arm Injuries/physiopathology* ; Disability Evaluation ; Extremities ; Female ; Forensic Medicine/methods* ; Humans ; Joints/physiopathology* ; Leg Injuries/physiopathology* ; Male ; Peripheral Nerve Injuries/physiopathology* ; Range of Motion, Articular/physiology* ; Trauma Severity Indices

ObjectiveTo investigate the main clinical characteristics of patients with autoimmune hepatitis (AIH). MethodsAn analysis was performed on the data of 194 AIH patients who visited Guanggu Branch of Hubei Provincial Hospital of Traditional Chinese Medicine from December 2010 to December 2014 and 197 healthy blood donors who served as control group. Autoantibodies, biochemical indicators, and liver biopsy were evaluated for AIH patients. The type of AIH patients was determined according to the results of test of autoantibodies and a statistical analysis was conducted for age, sex, biochemical markers, and pathological manifestations of all the AIH patients, Comparison of continuous data between groups was made by analysis of variance and comparison of categorical data between groups was made by chi-square test. ResultsThe female/male ratio was 154∶40 among the 194 AIH patients. The morbidity achieved a peak value among the patients aged 40-60 years. The proportion of the patients older than 40 years were 76.80% (149/194). According to the results of test of autoantibodies, the numbers of type-Ⅰ, -Ⅱ, and -Ⅲ AIH patients were 163, 5, and 26, respectively, the female/male ratios were 131∶32, 4∶1, and 19∶7, respectively, and the mean ages were 59.26±10.24, 16.54±8.21, and 63.38±12.92 years, respectively. There were significant differences in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, and immunoglobulin G between type-Ⅰ AIH patients and type-Ⅱ and -Ⅲ AIH patients (all P＜0.05), and immunoglobulin A significantly differed between type-Ⅱ AIH patients and type-Ⅰ and -Ⅲ AIH patients (P＜0.05). Pathological manifestations of AIH showed interface hepatitis, infiltration of lymphocytes and plasma cells, and rosette-like changes. ConclusionAIH patients are mostly female aged 40-60 years. The peak age of onset ranges from 40 to 60 years. Biochemical indicators have various degrees of increase among type-Ⅰ, -Ⅱ, and -Ⅲ AIH patients. The main pathological manifestation is interface hepatitis.