Objective To explore the effect of zingiberol combined with purple burn ointment in prevention of chemotherapy- induced phlebitis. Methods 200 cases of peripheral intravenous chemotherapy were randomly divided into the experimental group and the control group with 100 cases in each. The control group was given conventional infusion chemotherapy drugs, the experimental group used zingiberol combined with purple bum ointment to embrocate the skin around the vein to prevent phlebitis. After chemotherapy, the results were observed and recorded. Results The incidence of phlebitis in the experimental group significantly reduced compared with the control group. Conclusions Embrocation with zingiberol and purple burn ointment can prevent chemotherapy-induced phlebitis, which is simple with significant effect.