1.Effects of flavonoids from Cuscuta chinensis on ovarian endocrine in female rats exposed to psychologic stress
Jianhong WANG ; Minzhang WANG ; Qinghua WU ; Jianxin MIN ; Xiaofan CHEN ; Dong OUYANG
Chinese Traditional and Herbal Drugs 1994;0(12):-
Object To observe the effects of the flavonoids extracted from Cuscuta chinensis Lam. (FC) on the ovarian endocrine functions in female rats exposed to psychologic stress. Methods Sound, light and electricity were combined into a stressful stimulus to induce dysfunction on ovarian endocrine functions in female rats; to observe the effects of FC on the ovarian endocrine functions in female rats exposed to psychologic stress, by determining the changes of serum E 2, P and ascorbic acid levels in adrenal gland, and by weighing the pituitaries, ovaries and uteruses. Results FC increased the serum E 2, P and the weight of pituitaries, ovaries and uteruses obviously, but did not increase ascorbic acid levels in adrenal gland in female rats exposed to psychologic stress. Conclusion FC improves the ovarian endocrine functions in female rats.
2.Factor analysis model for studying the influence of psychological stress on the endocrine network of reproduction axis.
Laicheng LUO ; Jianhong WANG ; Na MA ; Haiyun LIU ; Minzhang WANG
Journal of Biomedical Engineering 2008;25(6):1368-1371
In order to explore the influence of psychological stress on the reproductive axis, we started with the original data of biology from animal experiments, then we conducted the factor analysis of 6 important bio-regulatory factors and established the Factor Analysis Model for the endocrine network of reproduction axis under psychological stress. Based on the biological data obtained from animal experiments, it is found that, compared with the relationship seen in the factor analysis model in normal condition, the relationship among the biological factors is more complicated. The key factor, GnRH, has lost its strong regulating action on the subordinate factors, especially on E2; on the other hand, beta-EP has very strong regulating action on E2, and E2 is controlled mainly by beta-EP.
Animals
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Estradiol
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blood
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physiology
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Female
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Follicle Stimulating Hormone
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blood
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physiology
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Gonadotropin-Releasing Hormone
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blood
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physiology
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Models, Biological
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Neurosecretory Systems
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physiology
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Rats
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Reproduction
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physiology
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Stress, Psychological
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metabolism
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physiopathology
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beta-Endorphin
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blood
;
physiology
3.Early experience of lung transplantation using graft lungs from donation after citizens death
Xin XU ; Guilin PENG ; Bing WEI ; Chunrong JU ; Dong XIAO ; Minzhang GUO ; Zhexue HAO ; Wei WANG ; Weiqiang YIN
Chinese Journal of Organ Transplantation 2017;38(8):455-458
Objective To report the results of lung transplantation using graft lungs from donation after citizens death.Methods The clinical data of lung transplantation between January 2016 and June 2016 were analyzed retrospectively.Results Totally 20 patients with end stage lung diseases underwent lung transplantation.Of the 20 patients,11 cases (55%) underwent single lung transplantation and 9 cases (45 %) underwent bilateral lung transplantation.The top two diseases for lung transplantation were pulmonary fibrosis in 11 cases (55%) and emphysema in 6 cases (30%).Four cases (20%) were given intraoperative ECMO support.Median duration of postoperative intubation was 2 days:1 day for single lung transplantation and 4 days for bilateral lung transplantation,respectively.Acute rejections were diagnosed in 9 patients (45%) who were successfully treated with high-dose intravenous methylprednisolone or methylprednisolone combined with anti-human thymocyte globulin.Postoperative pneumonia episodes occurred in 16 cases (80%)and 4 of them were associated fungal pneumonia.Preoperative sputum culture showed positive bacteria in 16 donors (80%) and 17 kinds of strains were identified.Postoperative sputum culture showed positive bacteria in 19 recipients and 4 of them had the same strains as compared with the corresponding donors.One recipient died of primary graft dysfunction in early term (< 1 month)postoperatively,two recipients abandoned treatments and died in 1 week after the discharge,and the remaining 17 cases successfully recovered.Median hospital duration was 55 days:35 days for single lung transplantation and 67 days for bilateral lung transplantation,respectively.Conclusion LLung transplantation is an effective treatment for end-stage lung diseases.Carefully selecting donors,well protecting graft lung and proper peri-operative treatment are the key steps leading to successful lung transplantation using grafts from organ procurement organization.