AIM:To explore the changes in immune function children patients with repeated respiratory infection(RRI)and the influence of nucleotide and casein injection on it.METHODS: 45 patients with RRI were arranged in therapy group and were injected with nucleotide and casein injection.32 patients with acute respiratory infection were arranged in control group who were not injected with nucleotide and casein injection.The effect of treatment, change of IgA,IgG,IgM,T-lymphocyle subgroups and reaction intensity of PHA were observed.RESULTS: There were very significant decline of IgA and IgG level(P

Objective To assess the value of intheleukin-6 (IL-6) in early diagnosis of children with acute lower respiratory tract bacterium infection . Methods Serum IL-6 levels of 85 children with acute lower respiratory tract infection were detected by ELISA and c-reactive protein (CRP), white blood cells (WBC), ploymorphonuclear (PMN) were measured in acute phase. Results When indices above were judged independently ,the reliability of IL-6 was highest with its sensitivity, specificity, positive predictive value (PPv), negative predictive value (NPV) and Youden’s index being 84% ,94% ,93% ,87% and 0.78 respectively .While united tests were used , diagnosis accuracy of IL-6 combining CRP was superior to classical indices (CRP,WBC,PMN). Conclusions The combination of IL-6 and CRP seems to be a valuable parameter in the early diagnosis of children with acute lower respiratory tract bacterium infection .

Objective: To explore the mechanism of traditional Chinese medicine(TCM) combined with regular therapy in the treatment of pneumonia with systemic inflammatory response syndrome(SIRS) in(children).Methods: Sixty-four children with pneumonia including 51 cases with SIRS complication were(randomly) divided into three groups: treatment group(regular therapy+TCM,n=26),control group Ⅰ((regular)(therapy) only,n=25) and the control groups Ⅱ(13 pneumonia children without SIRS(receiving)(routine) treatment). The dynamic changes of tumor necrosis factor-?(TNF-?),interleukin-6(IL-6) and IL-8 were measured before and after treatment in all children.Serum Creactive protein(CRP) and total white blood cell(WBC) count were measured simultaneously.Clinical symptom and sign scores were(performed)(5 days) after treatment in children with pneumonia and SIRS complication.Results: Before(treatment),serum TNF-?,IL-6,IL-8 and CRP concentrations were significantly higher in treatment group and(control) group Ⅰ than(control) group Ⅱ(all P