OBJECTIVE:To improve medication safety and efficacy.METHODS:5different tablets broken off with hands were investigated with respect to weight variations and microbial limits by reference to Chinese Pharmacopeia.RESULTS:The5kinds of tablets broken off with hands were not in conformity with Chinese Pharmacopeia with respect to weight variation and which involved different degrees of microbial contaminations.CONCLUSION:It is recommended that pharmaceutical enter?prises should add more dosage forms of standard drugs that suitable for the use of children,women,the aged and particular patients.If the separately packaged drugs must be broken off with hands,aseptic method should be applied in which the drugs were broken off by the pharmacists on the sterile air bench before being separately packed with sterilized plastic pouches(which were sterilized with anprolene),and which should be administered to the patients for taking during the same day.

OBJECTIVE:To observe the efficacy of telmisartan combined with metoprolol in the treatment of chronic heart failure.METHODS:102 patients with chronic heart failure admitted in hospital from Jan.2008 to Feb.2010 were given therapy of cardiotonic,diuresis,vasodilator,anti-infection,blood sugar control.Then patients were additionally treated with telmisartan and metoprolol.The parameters before treatment and after 2 weeks of treatment were determined such as heart function,24 h dynamic electrocardiogram,Bultrasound of heart,blood pressure,heart rate,6 min walking distance,liver and kidney function,electrolytes,blood sugar,urine routine,myocardial enzyme.RESULTS:After treatment,cardiac function,heart rate and 6 min walking distance,left ventricular ejection fraction(LVEF),the number of premature beats were significantly reduced(P