1.Research on the Methods of Medical Ethics Appraisal
Chinese Medical Ethics 1996;0(01):-
Medical ethics appraisal is not only an importance form in the medical ethics practice activity, but also an important content of the medical ethics system. Therefore, it's the prerequisite and foundation for medical ethics appraisal to produce the expected effect by choosing and using the appropriate appraisal method. This article has briefly described the commonly used effectual methods in our country at present, and carried on the exploration and analysis on the medical ethics quantitative appraisal methods especially.
2.Moral request for medical stuff to cure AIDS
Chinese Medical Ethics 1994;0(05):-
In the course of preventing and controlling AIDS,the greatest obstacle is discrimination to AIDS patients and infected people.Each country has taken some measures to argue against the discrimination,including definite regulations raised to medical stuff.The article discusses moral request for medical stuff to cure AIDS.
3.Hospital Culture and Medical Ethics
Chinese Medical Ethics 1995;0(03):-
This paper discusses and analyses the relationship between hospital culture and medical ethics from lots of points of riew such as hospital culture producing and formation, concept and intension of hospital culture, function and role of hospital culture and so on. Hospital culture and medical ethics are not only the measures to realize the medical aim but also the code of medical actions. Both of them have identity in content which can mutually help in function and improve each other in aim. So hospital culture contruction and medical ethics improvement will be coordinated growth.
5.Rethinking of resistant spirit to SARS
Chinese Medical Ethics 1995;0(03):-
The author expounded all kinds of spirits,including natural spirit, scientical spirit,humanism spirit,professional responsibility and contribution spirit during the course of resisting SARS.Those spirits not only bronght into play an important role in the period of SARS,but also will have a signifance affect after SARS.
6.Discussing the medical moral under surveillance
Chinese Medical Ethics 1996;0(01):-
The medical moral unders surveillance is not only an important content of building medical ethics,but also a powerful guaranty of bringing the medicine under control by moal and law.The author purposed the meanings、method and principles of the medical moral under surveillance in order to make the people pay attention and reserach more deeply.
7.Double-subjective Quality and Sociological Connotation of Doctor-patient Relationship
Chinese Medical Ethics 1995;0(03):-
This article comprehensively analyzes the double subjects and intersubjective quality of doctor-patient relationship,furthermore,it analyzes several facets of the intersubjective quality of doctor-patient relationship,such as technology,economy,management,etc.It discovers that doctor-patient relationship doesn't mean the only relationship between doctors and patients,but it also reflects the social relationship in the fields of medical treatment.It will help to activize the enthusiasm of both doctors and patients,and promote the development of medicine if we analyze the doctor-patient relationship from the point of view of sociology.
8.Antitumor effects of CIK cells against hepatocellular carcinoma cells in vitro and in vivo
Qingyou DU ; Mingxu LIU ; Fusheng WANG
China Oncology 1998;0(04):-
Purpose:To evaluate the antitumor effects of human cytokine-induced killer (CIK) cells from healthy donors and patients with primary hepatocellular carcinoma (HCC) in vitro and in vivo .Methods:Peripheral blood mononuclear cells (PBMC) from healthy donors and patients were induced to become CIK cells by in vitro incubation. The CIK cells were identified at different intervals by flow cytometry analysis. The cytotoxicity of CIK cells against autologous primary HCC was determined by 51Cr Release Assays. The antitumor activity of the CIK, LAK and PBMC cells were evaluated in Balb/c nude mice bearing BEL-7402liver cancer.Results:The flow cytometry analysis showed that CIK cells from patients with HCC proliferated and expanded more than 300-fold in vitro incubation by day 28;the percentage of CD3+CD56+ cells increased from 0.23% on day 0 to 17.8% on day 21. CIK cells generated from patients with HCC patients possessed a higher antitumor cytotoxic activity on autologous HCC cells in vitro than autologous PBMC. In addition, CIK cells had a stronger suppressive effect on the tumor growth in Balb/c nude mice bearing BEL-7402 tumor than LAK cells (median inhibitory rates 84.7% vs 52.8%, P
9.DETECTION OF HIV CORECEPTOR CCR5 MUTATION IN UIGUR POPULATION FROM SINKIANG UIGUR AUTONOMOUS REGION
Mingxu LIU ; Fusheng WANG ; Le JIN
Medical Journal of Chinese People's Liberation Army 1983;0(02):-
Whole blood samples were collected from 316 Uigur subjects inhabiting Kashi City, Sinkiang Uigur Autonomous Region, and their genomic DNA was extracted using QIAgen Blood Kit. DNA fragment spanning CCR5?32 and CCR5m303 mutation points were amplified by PCR and genotyped by directed electrophoresis and RFLP with HinCII respectively. In all 316 samples only 22 heterozygotes of CCR5?32 were found, in accordance with Hardy Weinberg equilirium. No CCR5m303 mutation was found. No difference existed between male and female individuals. The frequency of CCR5?32 in Uigur population is 3.48%, similar to Medi Asia ethnic groups (higher than that of Chinese Han people and lower than that of Caucasian people), i.e, in continuity regarding district distribution. Due to its slow down effect on clinical course of AIDS , high frequency of CCR5?32 is highly significant in prevention and treatment of AIDS in Uigur population.
10.Property and implication of dendritic cells from peripheral blood monocytes in patients with persistent hepatitis B virus infection.
Lihe XING ; Fusheng WANG ; Mingxu LIU
Chinese Journal of Infectious Diseases 2001;0(06):-
Objective To identify the property and implications of dendritic cells of peripheral blood monocytes (PBMC) in patients with persistent HBV infection. Methods The PBMC from 18 patients with persistent HBV infection and 10 healthy subjects were incubated and induced into mature dendritic cells (DC) in the completed medium containing GM CSF、IL 4、FLt3 L and TNF ? cytokines. The flow cytometric analysis was employed to detect the expression of surface markers on DC. ELISA test was used to determine the level of interleukin 12 (IL 12) and IL 10 cytokines produced by DCs. The stimulatory capacity of DC were also determined in allogenic mixed leukocyte reaction (MLR). Results A typical morphology of DCs was observed when the PBMCs from healthy subjects and HBV infected patients were induced for 6 7 day in vitro incubation, but there were some significant differences of DCs as follows: (1) the proliferation ability and number of DCs significantly decreased, in particular, the expression levels of HLA DR,CD80(B7 1),CD86(B7 2) and CD1? on DC surface were simultaneously much lower in patients compared to healthy subjects ( P