In this experiment, we investigated with enzymological methods the mechanisms of increase in serum high density lipoprotein cholesterol (HDL-C) in rats fed with concentrated fish oil. The rats were fed with high fat diet (Group 1), high fat plus olive oil (Group 2) and high fat plus concentrated fish oil (Group 3) for 6 weeks respectively. The concentrated fish oil contained about 26% methyl-eicosapentaenoate (EPA-M) and 52% me-thyl-docosahexaenoate (DHA-M), and was given in 0.5ml/day for each animalThe results showed that HDL-C levels in the serum of rats fed with fish oil were markedly higher than Group 1 and 2 (p

The mechanism of decreasing platelet aggregation by fish oil rich in n-3 fatty acids was studied in rabbits and rats. These animals were randomly divided into four groups. In rats, group Ⅰ was fed a basal diet; group Ⅱ was fed a high fat diet containing 7.5% lard, 0.25% bile salts, 0.5% cholesterol, group Ⅲ and Ⅳ received the diet with 5% lard, 0.25% bile salts,0.5% cholesterol and 0.5 ml fish oil or 0.5ml olive oil respectively. In rabbits, group Ⅰ was fed a basal diet; group Ⅱ received 20g diets containing 10.4% lard, 2.5% cholesterol, then, some basal diet; group Ⅲ and Ⅳ received 20g diets with 4.2% lard, 2.5% cholesterol and 2 ml fish oil or olive oil respectively, then, some basal diet. Fish oil contained 20% EPA and 50% DHAThree months later, plasma TXB2/6KPGF1? ratios were 1.4, 2.2, 1.0, 1.7. Plasma TXB2, cholesterol, serotonin, calcium, fibrinogen and blood viscosity were significantly lowered in group Ⅲ as compared with group Ⅱ. Platelet cAMP was greatly increased in group Ⅲ than that in group Ⅱ n-3 fatty acids in platelet, plasma and tissues such as liver and heart were definitively higher in group Ⅲ.These experiments showed that fish oil inhibited platelet aggregation and thrombosis formation as a consequence of changing the fatty acids composition in tissue membrane and decreasing TXA2/PGI2 ratio which may stimulate platelat cAMP synthesis and then decrease some agglutinating factors such as serotonin and calcium etc, released from platelet. On the other hand fish oil lowered blood cholesterol, which may change blood cell membrane fluidity, lowered blood fibrinogen and viscosity, so the situation of blood platelet and its surroundings could be improved.

ObjectiveTo explore the curative effects of Puerarin Injection associated with Irbesartan on decompensated chronic cor pulmonale heart failure. MethodsA total of 168 cases conforming to the diagnostic standards were randomized into control group (92 cases) and therapy group (76 cases). In the control group: Based on the results of sputum and X-ray, broad-spectrum antibiotics were firstly selected and used for 3 days after admission. Then sensitive antibiotics were selected according to the results of sputum culture and drug sensitivity test. Medicine for relieving cough and asthma, and apophlegmatisant were used routinely. Patients with heart failure were treated with Digoxin or diuresis. In addition to the above treatments, the therapeutic group were treated with Puerarin Injection 600mg and Irbesartan 75mg once a day. The two groups were both treated for 20 days. Results①The incipient slope, 0.8 slope, 0.5 slope and the minimal surplus were all significantly changed (P＜0.01) in therapeutic group after the treatment. There were significant difference in the incipient slope, 0.8 slope, 0.5 slope and the minimal surplus before and after treatment both in the control group and therapeutic group. ②The plasma viscosity and blood viscosity decreased observably (P＜0.01) after the treatment in the therapeutic group, and more obviously than that in the control group (P＜0.01). ③The arterial oxygen pressure (PaO2) and arterial oxygen saturation (SaO2) in the therapeutic group were enhanced more prominently than that of the control group (P＜0.01). ④The mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) decreased obviously in the therapeutic group after the treatment, and more observably than those in the control group (P＜0.01). ⑤The cardiac output and cardiac index were improved prominently in the therapeutic group after the treatment, and more obviously than that of the control group (P＜0.01). ⑥The heart functional capacity (NYHA) improved significantly after the treatment both in the control group and the therapeutic group (P＜0.05). ConclusionsPuerarin Injection and Irbesartan could remarkablely change the erytlu'ocyte deformabifity, improve the hemorheology, lower pulmonary hypertension, and improve the cardiac function and the clinical efficacy in decompensation stage.

For observation of the therapeutic effect of some foods on hyperlipi-demia in men, study was perfomed with subjects of hyperlipidemia by using mushroom, soya bean meat, beans, garlic, spring onions, prawn, chives, walnut seeds, peanut seeds, fishes etc. After 3 months treatment, the average values of serum total cholesterol and triglyceride were decreased significantly. The percentage of serum high-density lipoprotein cholesterol in the total cholesterol was increased from 24.7% to 31.3%; the percentage of serum low-density lipoprotein cholesterol was decreased from 61.8% to 49.2%. The curative rates of subjects with hypercholesterolemia were 93.3%, and the subjects with hypertriglyceridemia were only 50.0% and 57.1%. The effective rates were 79-87%.

The therapeutic effects of Chinese mushroom on hyperlipidemia in male adults were investigated. The subjects taking mushroom tablet (10g/day) were divided into ordinary diet (n = 18) group and hypernutritive diet (n = 16) group. After 3-month treatment, the mean values of serum total cholesterol and triglyceride were significantly decreased by 59.5 (P

The effects of fish oil rich in eicosapentaenoic acid (C20:5?-3; EPA) and docosahexaenoic acid (C22:6?-3; DHA) on serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels were investigated in experimental hypercholesterolemic rats. The fish oil contained about 15% EPA and 43% DHA. Each animal was given 1ml fish oil/day by intragastric feeding for 30 days. The results in twice experiments showed that TC concentration in the serum of rats fed fish oil was markedly decreased as compared to rats fed olive oil, but serum HDL-C elevated. Furthermore, the ratio of HDL-C to TC in the serum was also significantly elevated in rats fed fish oil.