Objective To investigate the calcification of thyroid nodule detected on ultrasound and the relation with benign and malignant disease.Methods Data of 107 cases of malignant and 703 cases of benign(thyroid) nodules examined by high-resolution colored ultrasonography preoperatively and pathological diagnosis by paraffin embedded slides postoperatively were collected from our hospital over a period of 3 years.The(percentages) of calcification and fine stippled psammomatous(FSP) calcification in benign and malignant(nodular) disease,in different sexes and different age groups were retrospectively reviewed.Results The(incidences) of calcification and FSP calcification were significantly higher in malignant group(63.55%,(29.02%),respectively) than in benign group(P0.05).Calcification rate showed no(significant) difference between different age groups(0.05);however,there was a significant difference of the FSP calcification rate between different age groups(P