1.Exploration in curriculum system of medical bisciences specialty
Li ZHAO ; Shouwei WU ; Li HAN ; Jianjun ZHOU ; Gaofeng LIU ; Mingsheng BAO
Chinese Journal of Medical Education Research 2006;0(09):-
The article discusses the curriculum truss of medical biosciences major and the curriculum setup with basic medical courses as the foundation,highlighting the life science scopes and emphasizing integrated curriculum and the training of molecular biology technology to culture practical cross-subject talents in the life sciences for society.
2.Treatment of hepatitis B, liver cirrhosis complicated by liver carcinoma: liver transplantation
Jianli HAN ; Haoliang ZHAO ; Gaochao YANG ; Ying ZHAO ; Jiansheng LIU ; Jiansheng GUO ; Shiming WANG ; Yanbo MA ; Zhigang WEI ; Xifeng FU ; Mingsheng BAO
Cancer Research and Clinic 2010;22(5):329-331
Objective To summarize the clinical experiences of liver transplantation.Methods Of the nine patients, four operation was standard orthotopic liver transplantation,the latter five were the piggyback liver transplantation.The immunosuppressive protocols included methylprednisolone FK506 and mycophenolatemofeti. Meanwhile intravenous antihepatitis B immunoglobulin and Lamivudine were used to prevent hepatitis B recurrence.Results All patients were cured.Conclusion Liver transplantation can be employed for liver disease both cirrhosis and carcinoma as a conventional surgery.It is an effective way for the treatment of no metastatic liver carcinoma.The immunosuppressive protocols included methylprednisolone FK506 and mycophenolatemofeti,it can prevent immune rejection.
3.Effect of cisterna magna plastic repairing on cerebrospinal fluid dynamics in Chiari malformation type Ⅰ with syringomyelia
Changshun BAO ; Mingsheng CHEN ; Fubing YANG ; Ling ZHANG ; Liang LIU ; Bin WANG ; Ligang CHEN
Chinese Journal of Neuromedicine 2015;14(7):735-739
Objective To explore the effect of cisterna magna plastic repairing (posterior vertebral column resection and cerebella tonsillectomy and reconstruction of the cisterna magna by artificial dura) on cerebrospinal fluid dynamics in Chiari malformation type Ⅰ with syringomyelia and evaluate the efficacy of this surgical method.Methods Forty patients with Chiari malformation type Ⅰ with syringomyelia (CMI-SM),admitted to and diagnosed by MRIin our hospital from January 2011 to December 2013,were selected.All patients were treated with cistema magna plastic repairing.Phase-contrast MR imaging (PC-MRI) was performed,changes of cerebrospinal fluid dynamics indicators of cerebral aqueduct,pons ventral side and C3 ventral side were detected and compared and Japanese Orthopaedic Association (JOA) scale scores were evaluated 24 h before operation and 12 months after operation.Results No neurological deterioration or death was noted;JOA scores in all patients were increased from 7.89±3.52 to 12.53±4.32,with significant difference (P<0.05);post-operated PC-MRI indicated that the cistema magna formed well,spinal subarachnoid space was clear,syringomyelia in 30 patients was significantly reduced;as compared with those before operation,the stroke volume and mean flux were significantly increased,but maximum peak velocity was significantly reduced (P<0.05).Conclusion Cisterna magna plastic repairing can reduce syringomyelia,increase cerebrospinal fluid flow,and reduce peak flow of cerebrospinal fluid,which is an effective surgical procedure for Chiari malformation type I with syringomyelia.
4. Identification of the stroke type of hemorrhage and ischemic based on microwave measurement technique
Feng WANG ; Junlin BAO ; Huaiqiang LI ; Weihao PENG ; Jia XU ; Wei ZHUANG ; Jun YANG ; Haisheng ZHANG ; Xu NING ; Mingxin QIN ; Mingsheng CHEN
International Journal of Biomedical Engineering 2019;42(5):404-408
Objective:
To establish a microwave scattering parameter acquisition system to detect cerebral hemorrhage and cerebral ischemia animal models, and to study the non-contact rapid identification methods for the two stroke types.
Methods:
Rabbits were selected for modeling. Eight rabbits in the cerebral hemorrhage group were injected with autologous blood. Six rabbits in the cerebral ischemia group were treated with bilateral common carotid artery clamping and femoral artery bleeding. The measurement excitation source has a scanning frequency range of 300 kHz to 3 GHz and an intermediate frequency bandwidth of 30 kHz. The signal of the S21 phase was acquired. The collected microwave scattering signals were subjected to mean filtering, principal component analysis dimension reduction, and mean clustering and nearest neighbor analysis to realize the identification of stroke types.
Results:
The microwave scattering measurement method can reflect the changes of cerebral hemorrhage and cerebral ischemia. The phase of S21 decreases with the increase of blood loss and increases with the increase of ischemic duration. The results of the differential experiment showed that all 14 models were correctly identified.
Conclusions
The stroke identification system based on microwave scattering measurement can effectively distinguish rabbit cerebral hemorrhage model and ischemic model. This technology is low cost, portable non-invasive, simple operation and fast, which make it be a promising method for identifying pre-hospital stroke types.