1.Protective Effects of Huoxueyangyin Granule on Isoprenaline-induced Myocardial Ischemia in Rats
Lei SHI ; Mingqin SHEN ; Yunru PENG
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(04):-
Objective To study the protective effect of Huoxueyangyin granule on isoprenaline -induced acute myocardial ischemia in rats. Method The model was established by injecting isoprenaline. Results Huoxueyangyin Granule inhibited the increased locomotions of T wave and ST section of the abnormal ECG, decreased the level of LDH, protected myocardial SOD activity and reduced myocardial MDA production of isoprenaline-induced acute myocardial ischemia in rats. Conclusion Huoxueyangyin granule possesses protective effect on acute myocardial ischemia in rats.
2.Effect of Xiaoerkechuanning Granule on Allergic Asthma in Guinea Pigs
Yongfang DING ; Yunru PENG ; Mingqin SHEN
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(05):-
Objective To study the antiasthmatic effect of Xiaoerkechuanning Granule (KCN) in guinea pigs with allergic asthma. Method The allergic asthma model in guinea pigs was induced by ovalbumin (OVA), and detemine the incubation period of asthma, the content of malondiadehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in blood serum, histopathologic changes of lungs. Results The KCN can markedly prolong the incubatin period, increase the activities of SOD, alleviate the histopathologic changes. Conclusion KCN has obviously protective effects on experimental allergic asthma in guinea pigs.
3.Pharmacodynamic Optimization of Purification Technique for Acanthopanax Senticosus Harms
Xiaobin TAN ; Xiaobin JIA ; Mingqin SHEN ; Yunru PENG
China Pharmacy 2001;0(12):-
OBJECTIVE: To optimize the purification technique for the extract of Acanthopanax senticosus Harms. METHODS: The techniques of D- 101 macroporous resin adsorption, polyamide adsorption and n- butanol extraction were separately applied to purify the aqueous extract of Acanthopanax senticosus Harms. Syringin was detected by HPLC and total flavone was detected by UV. The anti- cerebral ischemia effects of three purified samples were compared using rat MCAO model and mouse decapitation gape model. RESULTS: The three purified samples all showed anti- cerebral ischemia effects, with the sample purified via D- 101 macroporous resin adsorption having stronger effects than the other two. The content of Syringin was correlated with anti- cerebral ischemia effects. CONCLUSIONS: D- 101 macroporous resin adsorption is a be-tter technique for purifying the aqueous extract of Acanthopanax senticosus Harms.
4.Study on inflammatory factors releasing and mechanism during cardiopulmonary bypass in children
Xiaoyun WU ; Fengwu KUANG ; Chun WU ; Zhengxia PAN ; Hong WANG ; Mingqin PENG
Journal of Third Military Medical University 2003;0(08):-
0.05). The levels of ET-1 increased significantly in 1 h after CPB (P0.05). Conclusion The priming fluid with dexamethasone and aprotinin could inhibit the CBP-induced IL-6, TNF-?releasing, but have no such effects on ET-1, TXB 2 and 6-Keto-PGF 1? .