ObjectiveTo explore the relationship between depression in stroke patients with cognitive impairment and possible factors. Methods236 cognitive impaired patients whose score of Scale of Elderly Cognitive Function (SECF) ≤90 were selected in this study from inpatients with stroke from 1997 to 2004. They were evaluated with SECF, the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS) and the Ability of Daily Living (ADL) immediately and 2 months after hospitalization.72 patients were in the depression group(SDS≥50),and 164 patients were in the no-depression group(SDS<50). Gradual regression analysis was applied. One factor was taken as dependent variable selected from immediate scores of SECF, ADL, SAS, and the change of scores of SECF, ADL, SAS, SDS, respectively, while others were taken as independent variables. ResultsThe improvement of depression and ADL were helpful to reduce the anxiety and improve cognitive function in depression group (P<0.05), as well as the improvement of anxiety and cognitive function were helpful to improve the depression and ADL (P<0.05).The negative correlation were found between the difference former and latter score of SDS and ADL, as well as between those of SAS and SECF (P<0.05).ConclusionPatients with cognitive impairment can be beneficial from reducing depression and anxiety companied with improving the ADL and cognitive function, which is also mutually beneficial.

ObjectiveTo investigate the relationship between post-stroke depression (PSD) and mood of anxiety and cognitive function, and to explore prognostic condition.Methods144 post-stroke patients were examined with the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS) and Scale of Elderly Cognitive Function (SECF). Scores of the depression group were SDS≥50 and scores of the group without depression were SDS<50. ResultsThe incidence of the depression was 40.27%, the suicidal intention was 17.36%. There was significant difference between two groups with lower cognitive function and higher rates of anxiety in the depression group (P<0.001). The re-examination revealed the emotion of depression and anxiety reduced obviously in the depression group after 2 months (P<0.001), the emotion of anxiety also reduced in the group without depression (P<0.01). The cognitive function had little improvement in two groups.ConclusionsPSD is closely related to the emotions of anxiety and cognitive function of patients, emotions of depression and anxiety all improve after 2 months hospitalization, emotions of anxiety also reduce in the group without depression. But the cognitive function improves slower, with no evident changes in 2 months.

ObjectiveTo study the relationship among positive, negative trait coping style and possible factors in college students of rehabilitation specialty.Methods38 college students of rehabilitation specialty were assessed with Trait Coping Style Questionnaire (TCSQ), Coping Style Questionnaire (CSQ), Eysenck Personality Questionnaire (EPQ), Symptom Checklist 90 (SCL-90), Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS). Gradual regression analysis was applied, in which, sub-scales of positive coping and negative coping of Trait Coping Style Scale were taken as dependent variable, while other scales were taken as independent variable.ResultsPositive coping had significantly correlated positively with EPQE and factor of asking for help, and negatively with EPQN and factors of elusion and sensitivity of human being. Negative coping significantly correlated positively with SDS, EPQN, factors of self-blame, hostility and psychosis, but negatively with factor of solving problem.ConclusionPhysical and mental health can be kept by maintaining emotion stabilization, reducing negative coping of self-abasement, self-blame, hostility and elusion, using positive coping of solving problem and asking for help.

ObjectiveTo explore the mental health status and related factors of college students of rehabilitation medicine.Methods38 college students of rehabilitation medicine were assessed with Symptom Check List 90 (SCL-90), Eysenck Personality Questionnaire (EPQ), Coping Style Questionnaire (CSQ), and Adolescent Self-rating Life Events Checklist (ASLEC). Data of students of rehabilitation medicine, medical students, common university students and young people were compared.ResultsSCL-90 scores of students rehabilitation medicine were significantly lower than that of medical students and common university students, also lower than that of young people (besides somatization and anxiety factors), and scores of some sub-scales of EPQ, CSQ and ASLEC of students of rehabilitation medicine were positive or negative relationship with some SCL-90 factors in different degrees (P<0.05～0.01).ConclusionThe mental health status of students of rehabilitation medicine is good in general, and the main affected factors on mental health are instability emotion, negative daily events and immature coping style.

ObjectiveTo explore the relationship between cognitive impairment after stroke and possible factors.MethodsThe stroke patients being in hospital from 1977 to 2004 were evaluated with (scale of elderly cognitive function, SECF), the self-rating depression scale (SDS), the self-rating anxiety scale (SAS) and the ability of daily living (ADL). 236 cases with SECF≤90 were considered as cognitive impairment and retested with 4 scales mentioned above 2 months later. Gradual regression analysis was applied, one factor was taken as dependent variable selected from sex, age, education, course of disease, etiological factor, hemiplegia side, SECF1, SECF3, ADL1, ADL3, SAS1, SAS3, SDS1, SDS3, while others were taken as independent variable.ResultsAfter two months treatment in hospital, scores of SECF and ADL of patients improved, SAS and SDS reduced significantly (P=0.000). The proportion of female and cerebral infarction in aged patients was higher and scores of ADL reduced significantly (P<0.05). The SDS scores of patients with long course of disease before hospitalization were higher; there was a small improved extent for ADL ( P<0.05). SAS scores of patients with high ADL were low (P=0.028).ConclusionEarly residential rehabilitation can improve ADL function and reduce depression of stroke patients.

Breast cancer stem cells comprise a sub-population, which enables the capacity for self-renewal and the potentiality for differentiation and high tumorigenicity. Growing evidence suggests that breast cancer stem cells most likely contribute to tumor generation, progression, relapse, metastasis and therapeutic resistance. Herein, the recent advances in breast cancer stem cells were highlighted in this review.

156 stroke patients were assessed retrospectively by Self Depression Scale. The incidence of depression after stroke,and the relationship of depression between age, course, location of impairment, the character of the stroke,and ADL ability were included in the study. The conclusion showed that depression was related significantly to severe impairment in ADL.

ObjectiveTo investigate the effect of puerarin on the expression of pigment epithelium-derived factor (PEDF) in the retina of diabetic rats.MethodsThe diabetic retinopathy rat model was established.Rats were randomly divided into three groups (normal,diabetic,and diabetic with puerarin injection).The pathological changes of the retinopathy were examined.PEDF was analyzed with PCR in different time point.Results Body weight of diabetic group [ ( 216.9 ± 8.37 ) g,and(179.1 ±7.56)g] was compared with normal group[ (298.2 -±6.78)g,and(323.5 -±6.45)g] in the 3 month and 5 month ( q =12.39,P ＜0.01 ; q =15.47,P ＜0.01 ).Blood glucose of diabetic group and diabetic with puerarin injection group was compared with normal group at each time point ( P ＜ 0.01,P ＜ 0.05 ).HE staining of the retina of diabetic rats indicated a diabetic retinopathy occurred in the early - stage in diabetic group,but changed slightly in the diabetic model with an injection of puerarin.The PEDF expression at the 5 month time point in normal group,diabetic group,and diabetic group with puerarin injection was 8.833 (1.200),1.650(3.300),and 8.350( 1.100),respectively.Compared with normal group and diabetic group with puerarin injection,the level of PEDF was significantly decreased in diabetic group (x2 =48.57,P ＜ 0.01 ;x2=48.46,P ＜ 0.01 ).ConclusionsPuerarin can alleviate the retinal pathological damage of diabetic rats,early intervention with puerarin can prevent from the expression of PEDF and delay the diabetic retinopathy process.

Objective To observe the clinical features, phenotypes and genotypes in a Chinese family with choroideremia (CHM). Methods A Chinese four-generation family (15 members) with CHM, including 5 patients (4 males/1 female), 2 female carriers and 8 healthy members, was enrolled in this study. Initially all family members underwent best corrected visual acuity (BCVA), indirect ophthalmoscopy, fundus fluorescein angiography, optical coherence tomography (OCT), visual field and full view electroretinogram (ERG). BCVA was followed up for 3 years. Venous blood samples were collected, and all of the 15 coding exons and flanking intron regions were amplified in the proband by polymerase chain reaction followed by direct sequencing. Protein structure was modeled based on the protein data bank and mutations in DeepView v4.0.1 to predict the effect of the mutations. A total of 180 healthy volunteers were enrolled as control group to matching CHM gene sequences. Results The visual acuity (VA) of 3/4 adult male patients began to decrease at less than 10, 10 and 30 years old, the average BCVA was 0.43. There were characteristic signs and symptoms of CHM including narrow visual field, extinguished rod and cone response in ERG, disappeared junction line and intermediate line of photoreceptor inner segment/outer segment on OCT. After 3 years, the mean BCVA decreased to 0.11. The BCVA of one young male patient was 1.0 in both eyes with minor changes fundus and visual field. The VA of the female patient began to decrease at 50 years old, her BCVA of two eyes were 0.5 and 0.25, respectively. The fundus changes were typical of CHM, with relative scotomas in the peripheral visual field of OD, and big scotomas in the OS. After 3 years, her mean BCVA decreased to 0.2. Of 2 female carriers, one had minor fundus changes (patches of pigmentary deposits, atrophy spots of retinal pigment epithelium cells), and the other was normal. A novel heterozygous c.1837G>A mutation in exon 15 of CHM was detected in the proband, which resulted in the substitution of serine by proline at codon 613 (p.D613N). Based on molecular modeling, the misfolded protein caused by the mutation might destabilize the structure of the helix that potentially could affect the global stability of the Rep-1 protein. Conclusions A novel c.1837G>A (p.D613N) mutation may be the causative mutation for CHM in this family. Female CHM carriers may have some signs and symptoms.

Objective To compare the bispectral index score ( BIS) correlationbetween standard frontal sensor position and an alternative zygomatic position under general anesthesia with propofol combined with remifentanil during neurosurgery. Methods Twenty patients undergoing neurosurgery were enrolled. Everyone received total intravenous anesthesia by target-controlled infusion of propofol and remifentanil. Two BISTM Quatro sensors mounted on the frontal and zygomatic regions were connected to BIS VistaTM monitors on each patient during general anesthesia.Data from each position were collected and analyzed at the time of awakening ( t1 ) , intubation ( t2 ) , incision ( t3 ) , the end of surgery ( t4 ) , and extubation ( t5 ) . Results At t1 , zygomatic BIS(88.95±6.42) was significantly lower than frontal BIS (84.85±9.64,P<0.01).But during anesthesia,different of BIS value was no statistical significance between the standard frontal position and an alternative zygomatic position(P>0.05). Scatter plot analysis revealed a significant correlation between BIS of frontal positionand that of zygomatic position( R2=0.892,P=0.000) . Conclusion During the anesthesia maintenance period,the zygomatic position can be availably used as an alternative position for monitoring if the operative field renders the standard frontal position unavailable.