1.Superselective renal artery embolization with lipiodol and absolute alcohol emulsion for renal tumor
Miao YU ; Jiakai LI ; Minglu SUN ; Huixian WANG
Journal of Interventional Radiology 2006;0(12):-
Objective To evaluate the efficacy of the renal arterial embolization with lipidol and absolute alcohol emulsion in the treatment of renal tumors. Methods The superselective renal arterial embolization by using coaxial-cathaterization with infusion of lipiodol and absolute alcohol (in proportion of 2 ∶ 1) emulsion was performed in twenty patients with malignant and benign kidney tumors. 4 weeks later, the renal arteriography was taken routinely and repeated embolization was performed in case of necessary; and follow up was carried out periodically. Results The imaging findings showed thorough tumor necrosis and feeding vessel abruption in 18 cases after one session of treatment. The volume of tumors decreased more than a half in 13 patients (82.25%, 13 / 18) associated with a well-distributed lipidol inside the tumors. The second session of treatment was performed in other 2 patients and the clinical symptoms relieved obviously. Conclusions The superselective renal artery embolization with lipidol and absolute alcohol emulsion can permanently embolize all tumor feeding arteries in capillary vessel level with maximum reservation of renal function, providing definitively efficacy and worthwhile to be recommended widely.
2. Effects and mechanism of dapagliflozin on myocardial injury in type 1 diabetes mice
Xuejiao ZHANG ; Jieting LIU ; Luxin LI ; Peijian CHEN ; Minglu DING ; Mengwei SUN ; Yanhui CHU ; Zhen ZHANG
Chinese Journal of Clinical Pharmacology and Therapeutics 2023;28(3):257-265
AIM: To investigate the effect of dapagliflozin on myocardial injury in type 1 diabetes mice and its mechanism. METHODS: Normal C57BL / 6J male mice were randomly divided into normal control group (Control), diabetes cardiomyopathy group (DCM) and dapagliflozin group (DAPA). The model of diabetes was induced by streptozotocin (STZ) and given maintenance feed. DAPA group was given 10 mg · kg