OBJECTIVE:To evaluate the status quo and the developmental trend of the application of antidepressant drugs in our hospital.METHODS:The antidepressant drugs in our hospital during2002～2004were analyzed retrospectively in terms of drug varieties,consumption quantity,consumption sum,DDDs etc.RESULTS:The consumption sum of the antidepressant drugs increased year by year,which stood at667.41,802.47and995.02(RMB:ten thousand yuan),respectively in the3years.CONCLUSION:Fluoxetine dominates the first place in terms of clinical application of antidepressants.Furthermore,the application of new type antidepresants has been on the rise.

OBJECTIVE:To evaluate the quality of Bifonazole Gel from different manufacturers. METHODS:HPLC was per-formed on the column of Diamonsil C18 with mobile phase of methanol- water- tetrahydrofuran(75∶24∶1,V/V/V)at a flow rate of 1.0 ml/min,detection wavelength was 254 nm,column temperature was 23 ℃,and the injection volume was 10 μl. RESULTS:The linear range of bifonazole was 50-600 μg/ml (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 1%;recovery was 97.71%-101.68%(RSD=1.16%,n=9). The contents of Bifonazole gel samples from 3 manufacturers were more than 10 mg/g,with little difference. CONCLUSIONS:The method is simple and accurate with good separation and re-producibility,and suitable for the content determination of Bifonazole gel. The investigated contents of products from different man-ufactures conform to relevant standards.

OBJECTIVE:To discuss the way to establish a scientific and rational quality guarantee system for total nutrient admixture(TNA).METHODS:The regulations and measures adopted to guarantee TNA quality were analyzed on the basis of TNA preparation practice in the hospital.RESULTS&CONCLUSION:TNA quality can be guaranteed to be secure and stable in quality by establishing an efficient quality guarantee system for TNA.