Objective To observe the clinical efficacy of hydrochloride minocycline ointment in the treatment of chronic periodontitis. Methods 40 patients( 100 teeth) with chronic periodontitis were divided into iodine glycerin group (control group)and hydrochloride minocycline ointment group (observation group). Before and after treatment, the changes of the periodontal depth, plaque index, tooth mobility, tooth week attachment level, gingival sulcus bleeding index were recorded and analyzed. Results There was no significant difference between the two groups before treatment (P > 0.05 ), and after treatment, the difference in every excerpt -time was significant (all P <0.05). Conclusion The treatment of hydrochloride minocycline ointment in chronic periodontitis was better than iodine glycerin, and could significantly improve the efficacy.

Amphetamine-type stimulants ( ATS ) , a group of new-type synthetic drugs mainly in psychological dependence, are abused more and more severely in recent years. MicroRNAs ( MiRNAs ) are an important class of endogenous non-coding small RNAs that mediate posttranscriptional negatively regulation of gene expression by targeting specific mRNA sequences to in-hibit the translation of mRNAs or degrade the expression of mR-NAs. ATS can induce the changes in the expression of miRNAs in addiction-related brain regions which directly involve in the regulation of ATS-induced addictive behaviors. Therefore, to study the regulatory role of miRNAs in ATS-induced addiction has important implications for dependent mechanisms of new-type drugs and the discovery of the new targets of drug actions.