Outlining the medicinal properties of unprocessed Rhizoma Pinelliae and its general usage nowadays,this paper highlighs the view of veteran TCM practitioner LI Ke on processed Rhizoma Pinelliae and the reasons for the clinical overdose application and its clinical effect.Besides,before proposing a new thinking to the clinical use of herbs in the future,the author concludes his clinical experience in application of unprocessed Rhizoma Pinelliae under the guidance of Master LI,particularly the application in the treatment of difficulty miscellaneous disease.

Artificial lung, also called oxygenator, has the properties of oxygenation, heterotherm, blood store, filtration, and blood retrieval, oxygenates venous blood with low oxygen to arterial blood with high oxygen, similar to human physiological condition, and functions as an ideal artificial organ. Membrane artificial lung has been widely used in extracorporeal circulation of cardiovascular surgery, as well as rescue of respiratory failure, i.e. extracorporeal life support or extracorporeal membrane oxygenation. And the intravascular oxygenator has been primarily used in clinic. In particular, membrane oxygenator is essential for patients with severe disease, poor heart function, and long-duration operation. Currently, based on membrane material modification and optimization, as well as experimental and clinical evaluations of various properties, studies of artificial lung focus on improvement of gas exchange and biocompatibility, so as to provide reliable means of rescuing patients.

Whether allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph - ALL) after the first complete remission (CR1) or not is still a controversial issue. Many studies have recently reported that adolescents and young adults with Ph- ALL may benefit from pediatric chemotherapy. Conventional baseline risk factors cannot satisfactorily predict prognosis, conversely, the early minimal residual disease (MRD) is the best stratification tool to offer different treatments for patients with different MRD status. Novel therapies, such as CAR-T cells and blinatumomab, have shown promising results in relapsed/refractory patients. Through comprehensive application of pediatric chemotherapy protocols, MRD driven strategy and novel therapies, it is hopeful to change the paradigm of how to treat adults with Ph - ALL in the future, and to bring improved outcomes and decreased adverse events.

Digital CR of head and neck overcomes the disadvantage of regular X-ray radiography, which can not reveal bone and soft tissue position deficiency in one exposing, and reduces the X-ray radiation dose. Meanwhile, various factors decline the imaging quality, and images must be enhanced in order to meet demands of doctors clinical diagnosis. The general enhancement algorithms don't consider bodys structure difference and density characteristics. A new adaptive CR enhancement algorithms was proposed in this article, and head and neck images were processed with this method and compared with linear unsharp masking method. The results proved that the details of CR image enhanced were abundant and enhanced CR had good visual effect. SNR was high, as well as detail variance/background variance (DV/BV) indicating that this algorithms is suitable for head and neck CR medical image.

Objective:To observe the clinical effects of Tip-Edge Plus appliance in treating bimaxillary protrusion patients and discuss its mechanics. Methods:20 patients with bimaxillary protrusion were treated with Tip-Edge Plus appliance. 4 premolars in all those cases were extracted. The results of cephalometric measurements of pretreatment and posttreatment were statistically analyzed to evaluate orthodontic effects. Results:20 patients received an average of 18 months of treatment,after treatment dental coverage and molar relations of these patients were in the normal range. Analysis of related projects cephalometric showed that patients with lateral outlook improved significantly,SNA,SNB and U1~L1 angle changes in hard tissue with significant difference in cephalometric measurements(P

Objective:To investigate the expression of osteopontin (OPN) mRNA and protein and its correlation with clinico-pathological features of salivary gland tumors. Methods:OPN mRNA and protein level were detected by fluorescent quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR)and Western blot in 41 cases of malignant salivary gland tumors,21 of benign salivary gland tumors and 10 of normal salivary gland tissues. The relationship between the relative content of OPN mRNA and protein and clinico-pathological features of salivary gland tumors were analyzed. Results:The differences of OPN mRNA and protein expression levels in various tissues (malignant salivary gland tumors,benign alivary gland tumors and normal salivary gland tissues) were statistically significant,and the mRNA expression levels were correlated significantly with node metastasis and TNMstage,the expression levels of OPN protein were correlated significantly with node metastasis and TNMstage(P

Objective: To research the method of Establishing model of polymyositis with damp-heat syndrome. Methods: 45 guinea pigs were randomly divided into three groups, group A (normal group), group B (experimental myositis group, control group), Group C (damp-heat group). In the control group, the rabbit skeletal muscle homogenate Garver,s complete adjuvant for subcutaneous immunization was used to injecting into the original guinea pigs. Besides the above-mentioned immune method, the heat-damp model method was used (feigan diet, hot and humid environment and pathogenic micro-organisms and other complex factors) to establish the polymyositis model with damp-heat syndrome. The general situations, such as the serum muscle enzymes, light microscopy, electron microscopy changes in each group were observed. Results: The results showed that the clinical performance, serum creatase, the pathological changes of skeletal muscle, lungs, liver of guinea pigs in damp-heat group were similar to the human polymyositis with damp-heat syndrome. Conclusion: The model can be used to study the human polymyositis with damp-heat syndrome, and provide the pathogenic and theoretical basis for treating polymyositis by TCM.

Renal involvement is common in systemic lupus erythematosus(SLE).Treatment of lupus nephritis includes immunosuppressive and supportive therapy.The intensity of immunosuppressive therapy depends on the clinical and renal pathological disease activity.The long-term targets of treatment are to prevent lupus nephritis relapse and protect renal function.Complete remission is the goal in the induction phase,and long-term treatment is necessary in the maintenance phase.Individualization therapy and the side effects of immunosuppressive agents should be paid more attention.

Objective To observe the different efficacy of combination of inhaled ipratropium bromide and salbutamol and inhaling the two drugs separately. Methods Sixty -five patients with COPD were divided into 3 groups,and treated with different drugs. We observed the lung function FEV1 , the improvement of symptoms and side - effects. Results The FEV_1 and improvement of symptoms in combination group were significantly better than those in seperatin group (P

The article analyzes the TCM etiology, pathogenesis of geriatrics and pathological basis and clinical treatment medication of several common geriatrics. Chinese herb formula with function of invigorating the kidney and promoting blood circulation has the preferable curative effect on geriatrics, so we consider that kidney defi ciency and blood stasis is the main pathogenesis of geriatrics. Invigorating the kidney and promoting blood circulation is an important treatment of geriatrics, and should be followed through the whole therapeutic process.