2.One case of a pregnant femal taking realgar induceing congenital inner ear malformation.
Mingfang DIAO ; Jianjun SUN ; Yang LIU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(15):1390-1391
A pregnant female taken realgar because of superstition, which caused the baby congenital deafness. Auditory test indicated that bilateral auditory brainstem response (ABR) hearing threshold level was greater than 90 dB nHL and auditory steady state response (ASSR) hearing level ranging from 0.5 kHz to 4 kHz was beyond 110 dB HL. Temporal bone CT showed that bilateral cochlear and semicircular canal malformations, with internal auditory canal broadened.
Arsenicals
;
adverse effects
;
Evoked Potentials, Auditory, Brain Stem
;
Female
;
Hearing Loss, Sensorineural
;
chemically induced
;
congenital
;
Hearing Tests
;
Humans
;
Infant
;
Maternal Exposure
;
adverse effects
;
Pregnancy
;
Semicircular Canals
;
pathology
;
Sulfides
;
adverse effects
;
Temporal Bone
;
pathology
3.Effects of N-methyl-D-aspartate on the cochlear potentials
Lan ZHANG ; Jinhui XIA ; Mingfang DIAO ; Wenyuan GAO
Academic Journal of Second Military Medical University 2001;22(12):1126-1129
Objective: To study the effects of TNFα on wound healing. Methods: The skin lesion and incisions were made on mice and rhTNFα was applied in both skin lesion and incision. Tissue strips were evaluated for tensiometry and histologic features after healing. Results: It was found that rhTNFα markedly improved wound healing both in skin lesion and incision wound model, it also markedly enhanced the breaking strength of treated incision and increased wound cellularity in rh TNF α treated groups. Conclusion: The results suggest that TNFα play an important role in regulating inflammatory reactions of local injured tissues and it may improve the functions of fibroblasts, mononuclear phagocytes and endothelial cells. rhTNFα of suitable doses can promote wound healing. This shows that TNFα, as a wound healing promoter, has the potentials for clinical application.
4.Effects of N-methyl-D-aspartate on the cochlear potentials
Lan ZHANG ; Jinhui XIA ; Mingfang DIAO ; Wenyuan GAO ;
Academic Journal of Second Military Medical University 1999;0(12):-
Objective: To investigate the effect of N methyl D aspartate(NMDA) on cochlear potentials and to find out the possible neurotoxic effect of NMDA on cochlea function in guinea pigs. Methods: After basal compound action potentials (CAP) and cochlear microphonics (CM) were recorded by round window electrode, animals ( n =5) were treated with Hanks applied to the round window membrane (RWM) for 20 min as control. Then 100 ?mol/L NMDA was applied to the RWM for another 20 min. Results: Hanks produced no obvious changes in CAP threshold, CAP N1 and CM latency and amplitude. CAP thresholds at all frequencies of tone burst were significantly elevated by application of NMDA, threshold shifts ranged from 13 27 dB. NMDA significantly reduced the CAP N1 amplitudes at all intensities of stimulations. CAP amplitudes were suppressed by 50% 75%. NMDA also significantly increased the CAP latency, the latency of CAP evoked by 6 kHz tone burst at intensity of -90 dB(output attenuation) was (1.9?0.06) ms after Hanks treatment and (2.76?0.21) ms after NMDA treatment ( P
5.Analysis on outer hair cells hazards from occupational exposure to low frequency electric and magnetic fields and magnetic fields and its related factors.
Jing ZHAO ; Jianjun SUN ; Zhonghong JIA ; Mingfang DIAO ; Yang LIU ; Fangjie TIAN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(22):1247-1251
OBJECTIVE:
To explore the function of outer hair cells and its influencing factors in the workers of occupational exposure to low frequency electric and magnetic fields.
METHOD:
502 high-strength LF EMFs-exposed workers were taken as the study subjects. The field intensity indicator and noise analyzer were employed for the examination of the electromagnetic energy intensity and noise value at the working sites. Self-administered questionnaires were adopted. Universal hearing screening by distortion product otoacoustic emission (DPOAE) and pure tone audiometry (PTA) were done. 100 workers who had abnormal POAE were taken as the observation group and 100 workers who had normal DPOAE were taken as the control group. The workers need be confirmed with ABR testing when the pure tone threshold of two consecutive frequencies were above 20 dB HL or DPOAE detection in any frequency did not pass. Multiple factor analysis with logistic regression was performed for the risk factors.
RESULT:
The average electric power density in job locations was 21-38 KV/m, which was higher than national standard (< 5 kv/m). Average noise-level in job locations was 52-65 dBHL, which was within the standard (< 85 dB(A). Questionnaire presented that low frequency electric and magnetic fields might increase the incidence of headache, insomnia and tinnitus in the observed group. The incidence of abnormal DPOAE was higher in the subjects of the observed group (P < 0.01). At 676, 933, 3616, 5 130, 7253 Hz, the DPOAE amplitudes of the observed group workers were significantly lower than the control group. Multivariate analysis showed that the risk factors of abnormal DPOAE included exposure of EMF, length of service, daily exposure time, conservatory measures might be protective factors.
CONCLUSION
The changes of DPOAE indicated that the exposure to low frequency electric and magnetic fields had a subtle, discreet and localized impairing effects on outer hair cells. Exposure of low frequency electric and magnetic fields, length of service, daily exposure time might be risk factors, conservatory measures might be protective factors.
Auditory Threshold
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Case-Control Studies
;
Electromagnetic Fields
;
adverse effects
;
Hair Cells, Vestibular
;
pathology
;
Humans
;
Magnetic Fields
;
adverse effects
;
Male
;
Noise
;
adverse effects
;
Occupational Exposure
;
Surveys and Questionnaires
6. Preliminary analysis of the effects of tailor-made notched music therapy on chronic idiopathic tinnitus
Ruru TIAN ; Mingfang DIAO ; Fangjie TIAN ; Jianjun SUN ; Xi LIN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2017;52(5):343-348
Objective:
Tailor-made notched music was applied to alleviate the symptoms of chronic idiopathic tinnitus and compared its effectiveness with other existing sound treatment of tinnitus.
Methods:
Subjects (