Philosophy has exerted greatly influences on both western medicine and Chinese medicine,both medicines have quite distinctive and interesting recognitions on illness and human being which reflect their own cosmology and its evolutionary progress.A renown scholar ZHU Xi in the Song dynasty of China has reached the peak of neo-Confucianism and elaborated a lot of theories on Chinese cosmology by summarizing scientific achievements at that time;while Immanuel Kant has done very similar to the western world of cosmology.However,their theories make obvious different.As far as the evolution of humankind is concerned,Karl Popper has contributed his distinguished idea that the brain is the center for evolution.To this point,the theory of Chinese medicine,regarding the human-brain as the Ni Wan,ocean of the marrow.Furthermore,the system that the Ren Meridian and the Du Meridian corresponding to human upright vertebrae column in traditional Chinese medicine,makes an in-depth sense,too.

AIM: To establish a specific method for identifying Bailing Capsule(Synnematum sinense,Yin et shen sp.now).METHODS: Using fermented cordyceps powder(C_S-C-Q80),adenosine and uridine as reference standards,a HPLC fingerprint at 260 nm has been established for identification of Bailing Capsule,using Alltima C_(18)(250 mm?4.6 mm,5 ?m) column and acetonitrile-0.04 mol/L KH_2PO_4 in gradient elution as a mobile phase.The flow rate was 0.8 ml/min. RESULTS: The relative standard deviations of stability,precision and reproducibility was less than 3% respectively.The relative standard deviation of relative retention time was less than 5% compared with other HPLC apparatuses and different colunms. CONCLUSION: The method established in this paper has the exclusivity and can be used to identify the Bailing Capsule.

Animals ; Apoptosis ; Cell Cycle ; Cell Cycle Proteins ; genetics ; metabolism ; physiology ; DNA Repair ; Homeodomain Proteins ; genetics ; metabolism ; physiology ; Humans ; Inhibitor of Growth Protein 1 ; Intracellular Signaling Peptides and Proteins ; genetics ; metabolism ; physiology ; Neoplasm Metastasis ; Neoplasms ; metabolism ; pathology ; Neovascularization, Pathologic ; pathology ; Nuclear Proteins ; genetics ; metabolism ; physiology ; Prognosis ; Receptors, Cytoplasmic and Nuclear ; genetics ; metabolism ; physiology ; Signal Transduction ; Transcription Factors ; genetics ; metabolism ; physiology ; Tumor Suppressor Protein p53 ; metabolism ; Tumor Suppressor Proteins ; chemistry ; genetics ; metabolism ; physiology

Animals ; Apoptosis ; Carcinoma, Hepatocellular ; pathology ; virology ; Cell Line, Tumor ; Cell Proliferation ; Hepatitis B virus ; Hepatocytes ; pathology ; virology ; Humans ; Liver Neoplasms ; pathology ; virology ; Trans-Activators ; genetics ; metabolism ; physiology

Autopsy ; legislation & jurisprudence ; standards ; Cause of Death ; Dissent and Disputes ; Forensic Pathology ; Humans ; Malpractice ; legislation & jurisprudence ; Medical Errors ; legislation & jurisprudence

AlM:To observe and compare the influence of different incision cataract phacoemulsification on comprehensive state in patients. METHODS: Sixty patients with cataract who were treated with phacoemulsification in our hospital from November 2012 to May 2014 were selected as research object, and they were divided into group A ( corneal incision group) 30 cases and group B ( corneoscleral rim incision group) 30 cases according to the disease state. Epithelial and incision repair time, tear break-up time, tear secretion, corneal staining score and tear related indexes before and after the treatment of two groups were respectively analyzed and compared. RESULTS: The epithelial and incision repair time constitution of group B were better than those of group A, the incision repair time, tear break - up time, tear secretion, corneal staining score and tear related indexes at 1,7, 14 and 28d after the treatment were all significantly better than those of group A too, there were all significant differences (all P<0. 05).CONCLUSlON: The application value of corneoscleral rim incision in the patients with cataract phacoemulsification is relatively higher,and bad influence of this method for the patients is smaller, the postoperative recovery of comprehensive state are faster.

AIM: To investigate the effect and mechanism of Mingjing decoction combining with argon laser on the levels of plasma vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy(DR).
METHODS:The 66 patients(118 eyes)with DR at Ⅲ ~ Ⅴstage were randomly divided into two groups (treatment group and control group). The control group (33 patients with 56 eyes ) was treated with argon laser, and the treatment group (33 patients with 62 eyes) was treated with mingjing decoction combining with argon laser, and a blank group(30 eyes) was set up. The levels of plasma VEGF were detected by enzyme linked immunosorbent assay (ELISA). The results of best corrected visual acuity and fundus fluorescein angiography(FFA) were analyzed, as well as detected glycosylated hemoglobin ( HbA1c), blood coagulation function and the function of liver and kidney.
RESULTS: Patients with DR had significantly risen plasma VEGF before treatment when compared with blank control group ( P < 0. 05 ). After 3mo of combined treatment, the levels of plasma VEGF significantly reduced and HbA1c decreased in patients treated with mingjing decoction and argon laser, there were statistically significant difference compared to control group ( P < 0. 05 ). In the treatment group, the best corrected visual acuity and FFA were significantly improved in patients treated with mingjing decoction combining with argon laser compared to patients treated with argon laser alone after 3mo of combined treatment. CONCLUSION: Mingjing decoction combining with argon laser for DR can effectively reduce the level of plasma VEGF, stabilize blood sugar levels, improve the function of retina, and delay DR progresses.

Objective To investigate the distribution and drug resistance state of Pseudomonas aeruginosa, so as to offer reasonable experimental data for clinical therapy. Methods A statistic analy- sis for the specimen souree, distribution of infected departments and drug resistance state to 441 iso- lates was conducted in a retrospective way. Results Among 441 strains, 357 (80. 95%) were isolated from sputum species. The department with the highest isolating rate was ICU (26.5%), followed by department of respiratory disease (20. 63 %), department of neurosurgery (19.05 %) and department of geriatrics (17. 01%). The most sensitive antibiotic was Meropenem, which total drug resistance rate was 13. 61%; the most insensitive antibiotic was ampicillin-sulbactam, which total drug resistance rate was 91.38%. The drug resistance rate of P. Aeruginosa was increasing year by year. Conclusion Clinical isolates of P. Aeruginosa mostly come from sputum samples and ICU, and they are highly and multidrug resistant to various antibiotics.

Objective To observe and compare the recent objective response rate and adverse reaction of docetaxe and irinotecan combined with cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Sixty-five patients with advanced NSCLC were randomly divided into goup A consisted of 33 patients received docetaxe plus capecitabine and group B consisted of 32 patients received irinotecan plus capecitabine with a 21-day regimen. Two or more cycles of chemotherapy were completed in each group. Results Sixty-five patients were assessable for efficacy and toxicities. In group A, 2 patients achieved complete response, 13 patients partial response, overall response rate was 45.45 % and the median progression-free survival (PFS) was 10.1 months. In group B, 2 patients achieved complete response, 12 patients partial response, overall response rate was 43.75 %, and the median PFS was 10.2 months. The efficacy and PFS were not significantly different between the two groups(P ＞0.05). The most common adverse reactions were myelosuppression and gastrointestinal response in the two groups. The main adverse reactions is anemia in group A and diarrhoea in group B. Patients in group A experienced more anemia. On the contrary,the rate in group B was more increased. No chemotherapy-related death was observed. Conclusion The effects of docetaxe combined with cisplatin and irinotecan combined with cisplatin in the treatment of advanced NSCLC are comparable and equivalent, and the adverse reactions can be tolerated.

Objective To discuss how to choose the method of anesthetization for childhood obstructive sleep apnea hypopnea syndrome(OSAHS).Methods 98 children with tonsillar and adenoidal hypertrophy were seleted,and were randomly divided into two groups.Tonsillectomy and adenoidectomy were performed for the group with local infiltration anesthesia,while Tonsil dissection and endoscopic-assisted adenoidectomy through nose were for the group with intravenous general anesthesia.Then blood loss,operation time,intake time,operation damage,psychological trau-ma,hospitalization fares and operative efficacy were compared.Results The group with general anesthesia lost more blood,underwent longer operations with higher cost;the group with local anesthesia had more operation damage,grea-ter psyhologieal trauma and sometimes general anesthesia was necessary for the children who didn't cooperate.But these two methods of anesthetization almost had the same operative efficacy,and the symptoms such as snoring,oral breathing and suffocating were significantly improved after surgery.Condusion Every method had own advantages and disadvantages.Local anesthesia was as effective as general anesthesia in treating childhood OSAHS.but the anes-thetization choice should vary with the situations.