[Objective]To provide reference for the clinical prevention and treatment of hypertension and its complication.[Methods]Summarize the hypertension and its complication,therapy of chemical and TCM drug,and pharmacological test,through analyzing the related literatures in CNKI,Chinese biomedical database (CBM),and wanfang and vip from 1989 to 2007.[Results]To study the key role of mechanism of hypertension and its complications on hypertension research.[Conclusion]The treatment of hypertension which can be caused by many factors and its complications should be"combination of disease and syndrome."

Objective To study the correlation of serum CA125 level and differentiation of endometriosis (EMs) and pelvic pain due to Ems.Methods The clincal data of 305 EMs patients were retrospectively analyzed,and they were divided into I,Ⅱ,Ⅲ,Ⅳ four stage according to r-AFS.The relevance of preoperative serum CA125 and differentiation of Ems and pelvic pain were assessed and statistically analyzed.Results The serum CA125 level was higher in Ⅲ,Ⅳ stage (69.4 ± 5.7) U/ml,(171 ± 11.5) U/ml than that in Ⅰ,Ⅱ stage (14.8 ± 1.2) U/ml,(36.3 ±3.0) U/ml,there was statistically significant difference (P ＜ 0.05).The positive rate of CA125 increased progressively (12.1％,21.5％,40.2％,63.9％),but the difference was not statistically significant(P ＞ 0.05).The pain syndromes in the clinical features of differentiation of Ems had obvious difference (P ＜ 0.05).Conclusion The serum CA125 detecting can be used in differentiation of Ems,and it has important value in diagnosis and prognosis of EMs.

OBJECTIVE: To realize the general use of product managing software in management of drugs in modern hospital. METHOD: The softwares for import, sales and storage of pharmaceutical products in modern hospital were analyzed and compared. The type with best data transplant was found out and grafted upon the module relation. The network technology of programming tool VB was adopted to establish the sensitivity of the effective word section in the database , and the structure of the data was set up in an selective way in the procedure initializing window. RESULTS: The chaining of the system with many kinds of databases was completed. CONCLUSION: The modern programming technology combined with effective establishment of the database can be employed to transplant the complicated data, and therefore the medicine management software can be expected to be in general use.

Objective To observe and compare the recent objective response rate and adverse reaction of docetaxe and irinotecan combined with cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Sixty-five patients with advanced NSCLC were randomly divided into goup A consisted of 33 patients received docetaxe plus capecitabine and group B consisted of 32 patients received irinotecan plus capecitabine with a 21-day regimen. Two or more cycles of chemotherapy were completed in each group. Results Sixty-five patients were assessable for efficacy and toxicities. In group A, 2 patients achieved complete response, 13 patients partial response, overall response rate was 45.45 % and the median progression-free survival (PFS) was 10.1 months. In group B, 2 patients achieved complete response, 12 patients partial response, overall response rate was 43.75 %, and the median PFS was 10.2 months. The efficacy and PFS were not significantly different between the two groups(P ＞0.05). The most common adverse reactions were myelosuppression and gastrointestinal response in the two groups. The main adverse reactions is anemia in group A and diarrhoea in group B. Patients in group A experienced more anemia. On the contrary,the rate in group B was more increased. No chemotherapy-related death was observed. Conclusion The effects of docetaxe combined with cisplatin and irinotecan combined with cisplatin in the treatment of advanced NSCLC are comparable and equivalent, and the adverse reactions can be tolerated.

ObjectiveTo investigate the prevention and management of the hemorrhage during laparoscopic cholecystectomy( LC), and improve success ratio. MethodsThe medical data of 420 cases with LC from May 2003 to 2009, September were analyzed retrospectively, including total number, hemorrhage site and ways of prevention and management. Results417 cases experienced successful C,with success ratio 99.3%. 49 cases ( 11.7% ) had hemorrhage, and in 46 cases(93. 9% ), it was stopped by laparoscope or hemostasis by compression,3 cases were rescued by operation. All hemorrhage sites included 15 cases(30. 6% ) in triangle de Calot,26 cases(53. 1% ) in gallbladder bed, and 8 cases ( 16.3% ) in incision. ConclusionA reliable opetration and appropriate hemostasis are critical of the successful operation and prevention of complications after LC.

Surface plasmon resonance (SPR) sensing technology is a high-tech optical detection technolo-gy developed quickly in recent years, which combines biology, polymer chemistry and sensing technologies to form a rapid, sensitive, specific, portable and easy to operate detection technology. This paper outlines the mech-anism of SPR sensing technology for detection of low molecular weight analytes, the main application methods and research progress, discusses the advantages and shortages of the method, and foretastes the development prospect of this technology.

The 2nd derivative spectrophotometry was developed fo r the content determination of gastrodine in Naomaitong Oral Liquid. This methodis simple and rapid. Its' teproducibility is well.

The phagocytic ability and fashion of two types of alveolar macrophages (AM) on coal dust were studied by differential interference contrast microscope, scanning electron microscope and image analyser. This study revealed the phagocytic ability of spherical AM on dust was higher than that of the flat AM. Both types of AM could extend long tenuous filopodia to the coal dusts around the cells. The coal dusts were attached to the cell surface and then were sunk into the macrophage. The amount of the phagocyted coal dusts per unit time were measured by image analytical method which is more exact than other methods. This paper provided not only a new approach for study phagocytosis of macrophage on inorganic dusts, but also some essential morphologic evidences for study of pneumoconiosis.

0.05).In 28 days before and after treatment,there was significant difference in H-B grade between two groups (P

Objective:To investigate the effects of oxaliplatin (OXA) and teniposide (VM-26) on proliferation and apoptosis of gastric cancer cell line BGC-823.Methods:MTT assay was used to examine the inhibition rate of cell growth when cells were treated at various concentrations of OXA and VM-26 alone or in combination. The apoptosis was examined by flow cytometry (FCM). The protein expression of cell apoptosis associated proteins caspase-9 and livin were examined by immunocytochemistry. Results:OXA or VM-26 effectively inhibited the growth of BGC-823 gastric cancer cells in a concentration-dependent manner at certain range of concentrations. The inhibitory rate of combined treatment with OXA and VM-26 was significantly higher than that of OXA or VM-26 alone (P<0.05). The value of combination index (CI) was 0.46. The rate of apoptosis cells induced by 1.25 μg/mL OXA was 6.13%, 13.86% and 21.48% at 12, 24 and 48 h. The apoptosis rate induced by 0.625 μg/mL VM-26 was 4.60%, 10.72% and 17.07% for 12, 24 and 48 h. In combined treatment group the apoptosis rate was 11.73%, 24.14% and 44.75% at 12, 24 and 48 h, respectively. The difference was significant between combined treatment group and single drug treatment group (P<0.05). Immunnocytochemical analysis showed that the expression of caspase-9 protein was up-regulated after being exposed to OXA (1.250 μg/mL) or OXA plus VM-26 (0.750 μg/mL), while the expression rate of livin protein was down-regulated. There were significant differences among different treatment groups as well as between treatment groups and control group (P<0.05).Conclusion:OXA combined with VM-26 has synergistic effects in inhibiting the growth and inducing apoptosis of gastric cancer BGC-823 cells.