A 45-year old male patient suffered mutilation of his fingers except for the thumb in the right hand, and a crush injury of the whole left hand simultaneously while operating a rolling machine. The right hand was reconstructed with a double 2nd-toe implantation. After training his pinch motion in the right hand, a myoelectric prosthesis was attached to the left hand. He used his right hand for pinching task and the left hand for grasping task. His DASH score was 173 before functional reconstruction of the bilateral hands, and it was 84 at 5 years after treatment. A comparison was made concerning the functional results between the right hand reconstructed with the toe transfer and the left hand with the myoelectric prosthesis in order to discuss the prognosis for each treatment.

Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Recently, gefitinib, a molecule target therapeutic drug, has offered a new approach for patients with non-small-cell lung cancer (NSCLC). This report describes the effects of gefitinib on bone metastases in two patients with NSCLC. The pain induced by a bone metastasis was relieved after the administration of gefitinib. Furthermore, the radiographs and CT findings showed sclerotic changes that matched those of the metastatic bone tumor after gefitinib administration in both patients. It is believed that gefitinib inhibited tumor cell proliferation and induced normal bone formation. In patients with NSCLC, gefitinib may be effective in the treatment of bone metastases.
Cell Proliferation ; Humans ; Lung ; Lung Neoplasms ; Neoplasm Metastasis ; Osteogenesis ; Quinazolines

STUDY DESIGN: A case-series study. PURPOSE: To assess the long-term clinical and radiographic outcomes after vertebroplasty using calcium phosphate cement (CPC) for treatment of osteoporotic vertebral fractures (OVF). OVERVIEW OF LITERATURE: Vertebroplasty has become common for the treatment of OVF. However, few studies have reported the clinical application of CPC to vertebroplasty. METHODS: We reviewed 86 consecutive patients undergoing 99 vertebroplasties using CPC. Following repositioning and curettage of the pathological soft tissue of the vertebral body (VB), vertebroplasty using CPC was performed in patients with osteoporotic burst fracture and pseudoarthrosis (procedure A). Vertebroplasty was also performed in patients with osteoporotic compression fractures (procedure B). Back pain and lower back pain were evaluated using the visual analogue scale (VAS). The VB deformity index was measured in a lateral radiograph as the ratio of the VB's height to its longitudinal diameter. RESULTS: The mean age at time of surgery was 77 years old. The mean duration of follow-up was forty-four months. All patients reported decreased pain according to the VAS immediately after vertebroplasty, and pain relief was maintained at the last follow-up in all patients without new OVFs. Complete bone union was observed in all cases by six months after surgery. The mean recovery rate of deformity index was 5.9% in procedure A and 0.02% in procedure B at the final follow-up visit. CONCLUSIONS: Vertebroplasty using CPC gave a satisfactory outcome and no delayed complications in elderly patients with osteoporotic vertebral fractures at follow-up times of at least two years.
Aged ; Back Pain ; Calcium ; Calcium Phosphates ; Congenital Abnormalities ; Curettage ; Dinucleoside Phosphates ; Follow-Up Studies ; Fractures, Compression ; Humans ; Low Back Pain ; Osteoporosis ; Pseudarthrosis ; Vertebroplasty