Adult ; Humans ; Lymphoma, Large B-Cell, Diffuse ; metabolism ; Male ; Receptor Protein-Tyrosine Kinases ; metabolism

Acupuncture Points ; Acupuncture Therapy ; instrumentation ; Catgut ; Female ; Humans ; Infertility, Female ; blood ; therapy ; Moxibustion ; Treatment Outcome

This study was designed to validate the correlation between integrated pharmacokinetic and therapeutic effects of alkaloids using bile processed Rhizoma Coptidis (BRC). Rats were divided into three groups: normal, disease model, model+BRC. Rats were induced to have an excessive heat syndrome. Rectal temperatures were collected at 0, 3, 6 and 9 h after single oral administration of the drugs. The plasma concentrations of three alkaloids were quantified at different times by UPLC-MS/MS after the administration of BRC. An approach of self-defined weighting coefficiency was created to the holistic pharmacokinetic profiles of alkaloids in BRC. The classified and integrated synthetic concentrations were obtained, and then the pharmacokinetic parameters of alkaloids were calculated from non-compartmental model analysis. The potential relationship between the integrated mean concentration of alkaloids and the antifebrile efficacy was investigated. The holistic t(max) of alkaloids was 1.11 h, the antifebrile effect of BRC at 3 h was improved over the model group. Double peaking appeared in the integrated blood concentration-time curve, the second t(max) of alkaloids was 4.82 h. The antifebrile effects of BRC at 3-6 h were significant, and the antifebrile effects at 6-9 h was decreased significantly. Dynamic variation of alkaloids of BRC in the body exhibited the similarity to the pattern of its antifebrile effect.
Administration, Oral ; Alkaloids ; pharmacokinetics ; Animals ; Bile ; Coptis ; chemistry ; Drugs, Chinese Herbal ; chemistry ; pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Rhizome ; chemistry ; Tandem Mass Spectrometry

Adult ; Aged ; Antineoplastic Agents ; therapeutic use ; Benzamides ; Chemotherapy, Adjuvant ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms ; drug therapy ; surgery ; Gastrointestinal Stromal Tumors ; drug therapy ; secondary ; surgery ; Humans ; Imatinib Mesylate ; Liver Neoplasms ; secondary ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Piperazines ; therapeutic use ; Pyrimidines ; therapeutic use

Objective To investigate the effect of posttraumatic stress disorder(PTSD) on the psychological healthy state among high school students in the earthquake regions.Method The samples were consisted of 666 high school students who had experienced the Wenchuan Earthquake.The Impact of Event Scale-Revised (IES-R) and Self Description Questionnaire (SDQ) were used to rate symptoms of PTSD and psychological states of high school students.Data were analyzed using correlation analysis and structural equation model analysis for male or female separately.Results (1) Because their scores of IES-R were higher than 35,22.67％ participants were considered as PTSD patients,girls accounted for 83 or 25.31％ of the total female;and boys accounted for 68 or 21.72％ of the total male.(2) Among female,avoid and awake systems of PTSD were correlated significantly with their psychological state significantly (r=0.101-0.181,P＜0.05).The result of structural equation model analysis was similar to correlation analysis,corresponding coefficients of path ranged 0.11 to 0.18 (P＜0.05).(3) Among male,intrude and awake systems were correlated with their psychological state significantly (r=0.111-0.313,P＜0.05).Corresponding coefficients of path ranged from 0.11 to 0.31 (P＜ 0.05).Conclusion Systems of PTSD effect clearly on the psychological state of high school students,and there are the gender difference among these relationships.The symptoms of PTSD influence interpersonal relationships,emotion,conduct,appearance and self-evaluation,but school work and stamina are not influenced in this study.

Hematopoietic Stem Cell Transplantation ; Hepatocyte Growth Factor ; pharmacology ; Humans ; Immunologic Factors ; pharmacology ; Postoperative Period

Adolescent ; Adult ; Angiofibroma ; radiotherapy ; Humans ; Male ; Nasopharyngeal Neoplasms ; radiotherapy ; Neoplasm, Residual ; Postoperative Period ; Young Adult

Age of Onset ; China ; epidemiology ; Dust ; Humans ; Occupational Exposure ; analysis ; Pneumoconiosis ; epidemiology

Aging ; Health ; Humans ; Longevity

astaxanthin is an effective antioxidant and natural pigment which has wide application. Phaffia rhodozyma is a good source of astaxantin, but wild strain has limited use in industry because of low production level of astaxanthin. Several mutants of Phaffia rhodozyma were obtained by exerting mutagen N-methyl-N-nitro-N -nitrosoguanidine. The growth curve suggested that pigments were mainly produced in the middle and latter periods of log phase. The pigments were extracted from Phaffia rhodozyma and analysed by esterification, thin layer chromatography and absorption spectrometry. It was proved that astaxanthin, astaxanthin diester and ?-carotene were the major components of the pigments produced by Phaffia rhodozyma. We also studied the pigments producing phase of Phaffia rhodozyma. and founded that astaxanthin was stable to light under butylated hydroxytoluene coexistance.