Objective To observe the effect of potassium sodium dehydroandrographolide succinate for injection (PSDS)combining with smecta enema treatment on children with autumn diarrhea.Methods 102 children patients with autumn diarrhea were selected and divided into the control group,the PSDS group and the combination group with 34 patients in each group.The control group received symptomatic supportive treatment,based upon this,the PSDS group received PSDS,and the combination group adopted PSDS and smecta enema treatment.The treatment effect was compared between the three groups.Results The effect of the PSDS group and the combination group was better than the control group,the effect of the combination group was better than the PSDS group.Conclusions Combination of PSDS with smecta enema treatment for children with autumn diarrhea has significant effect,but enough attention should be paid to peri-anal nursing.

Objective:To screen clinical pharmacists’ intervention points in the medical order safety management according to the classification of irrational medical order, ranking of risk and causes analysis in order to provide ideas and reference for clinical pharma-cists. Methods:The prior interventions and post reviews were conducted on medical orders in an intensive care unit of the hospital from July to December in 2014. Results:A total of 224 medical records and 6583 medical orders were intervened, reviewed and audi-ted. Among the medical orders, 653 cases were irrational with a ratio up to 9. 92%. The 653 irrational medical orders were mainly classified with incompatibility, inappropriate dosage and irrelevant combinations, and mainly D level errors according to the risk rating. Most of the irrational medical orders were due to the lack of professional knowledge. Conclusion: Clinical pharmacists should partici-pate in medical order safety management including interfering drug compatibility, dosage and combination therapy, which can reduce or even avoid the error occurrence in medical orders and promote safe and reasonable medication through reasonable medication training and prior interventions.

Objective] To analyse the course of treatment based on differentiation of signs of Hashimoto thyroiditis combined with many diseases, offering treating thought and medication experiences. [Method] Trace back and state the relative documents about the general conditions, diagnosis and therapy, symptoms-pointed treatment of 1 case of Hashimoto thyroiditis combined with many diseases, introducing Pro. Wumin's clinical experience in treating the patient. [Result] The patient was early or late diagnosed as fatness, hyperlipemia, hyperinsulinemia, sub-clinical Hypothyrea, thyroid nodule and type-2 diabetes, Pro. Wumin combined TCM with WM, the patient was control ed the diseases and kept stable. [Conclusion] Combination of TCM and WM treating Hashimoto thyroiditis accompanied with diseases above has good cure effect, the patient is satisfied with the improvement and result.

Objective To explore the safety,minimal invasion and cosmetic effect of endoscopic thyroidectomy.Methods From May 2007 to April 2008,among 413 cases of thyroid operations,238 cases were operated by endoscopic techniguc and 175 cases were operated by traditional methods.the operation time,intra operative blood loss,incision cosmetic score,postoperative hospitalization time,cost of hospitalization,and surgical complications between the two mehods were compared.Results Both groups of patients were operated successfully without postoperative bleeding,hoarseness,or hypocalcemia.Compared with traditional thyroid surgery,endoscopic thyroidectomy had less blood loss,shorter operation time,and higher-satisfaction cosmetic effect without significant scars or skin color changes.Conclusions Compared with traditional thyroid surgery,endoscopic thyroidectomy has the desired advantages of excelent cosmetic result,safety,and quick recovery.It is an ideal operation method for treatment of benign thyroid diseases.

Objective:To study the pharmaceutical care for patients with severe infection in ICU performed by clinical pharmacists. Methods:Clinical pharmacists participated in the medication treatment process of one case of patient with pulmonary infection after glioma resection. According to the medical history, clinical symptoms and lab results, the pharmaceutical care was given in the respects of anti-infection therapy, analgesia/ sedation, anti-platelet therapy, drug interactions,drug precautions and adverse drug reactions. Results:The compliance,therapeutic effect and medication safety of the patient were all improved by giving clinical pharmaceutical care. The vital signs of the patient were stable,the anti-infection therapy achieved satisfactory therapeutic effects,and then the patient transferred from ICU and continued to be treated with rehabilitation therapy. Conclusion:Clinical pharmacists in medical team can assist physicians on the basis of the status of patients with reasonable and effective individualized medication and provide professional and efficient pharmaceutical care with high quality.

Objective To observe the clinical efficacy of small needle therapy in the treatment of retrograde lumbar spine stenosis. Methods About 30 patients with retrograde lumbar spinal stenosis from June 2015 to March 2016 were set as control group;30 patients with the same disease from ApriI 2016 to December 2016 were set as observation group. The control method of traction and massage therapy, the observation group on the basis of increased by small needle knife therapy. Result The effect of the observation group was better than the control group, the difference was statistically significant (P<0.01). Conclusions Treatment of retrograde lumbar spinal stenosis with small needle knife therapy is effective in treating patients' pain and improving clinical effect. Well condition observation and nursing during the treatment can ensure the smooth progress of treatment, the correct guidance and urged patients to exercise to reduce the recurrence of the disease, has the vital significance.

Objective:To investgate the ease effects of local injection of ursolic acid both on orthodontic tooth movement distance and tooth root resorption in the rats, and to clarify its mechanism.Methods:Ninety-six male Wistar rats were used to establish models of orthodontic tooth movement.After the successful establishment of models,all the model rats were randomly divided into 0 (control group),0.5,1.0 and 2.0 mmol·L-1 ursolic acid groups (n=24).The rats were locally injected with different doses of ursolic acid into the palatal submucosal area adjacent to the right upper first molar ,once per 3 d,each time 50μL.The rats were respectively sacrificed on the days 1,3,5,7,10,14,21 and 28,then the distances of tooth movement were measured.HE staining was used to observe the morphologic changes of the root tissue of rats.Results:The tooth movement distances of rats in control,0.5,1.0,and 2.0 mmol· L-1 ursolic acid groups were increased with the prolongation of time (P<0.01).Compared with control group,the tooth movement distances of rats in 0.5 mmol·L-1 ursolic acid group 3,7,14,21 and 28 d after forcing had statistical significance (P<0.05 or P<0.01 );the tooth movement distances of rats in 1.0 and 2.0 mmol· L-1 ursolic acid groups 1 d after treatment had no statistical significance (P>0.05),but at the other time points,the tooth movement distances of rats had statistical significance (P<0.01).The tooth movement distances of rats had statistical significance between 0.5,1.0 and 2.0 mmol·L-1 ursolic acid groups 5,7,10,14,21 and 28 d after forcing (P<0.05 or P<0.01).The morphological results showed that the resorption pits were found on the surface of tooth root with the prolongation of loading time;in addition,with the increasing of the doses of ursolic acid, the absorption of root surface was relieved. Conclusion:Local injection of ursolic acid at the doses of 0.5,1.0 and 2.0 mmol·L-1 can reduce the distance of orthodontic tooth movement in the rats, and the distance of tooth movement in the rats is reduced with the increasing of its doses,and ursolic acid has the ease effect on the orthodoutic tooth root resorption.

The expression patterns of 5-hydroxytryptamine(5-HT),gastrin(Gas),β-endorphin(End),somatostatin(SS),vasoactive intestinal peptide(VIP),glucagon(Glu) and neuropeptide Y(NPY)-positive cells in the duck thymus were studied by the immunohistochemical method associated with image analysis.The result shows that these 7 kinds of neuroendocrine cells with strong intensity were differentially detected in the duck thymus.The End-positive cells were abundantly expressed in the thymic cortex,whereas the Gas,5-HT,SS,VIP,Glu and NPY ones were more frequent in the medullary and around the corticomedullary junction.Except Glu,the other 6 kinds of neuroendocrine substances with various intensity were expressed in the cells of thymic corpuscles.The observation demonstrated that the duck thymus is not only a primary lymphatic organ,but also has important neuroendocrine functions.The End-positive cells in the thymus may play crucial roles in the development of immature T-lymphocytes.The neuroendocrine cells with a predominant distribution in the medulla and around the corticomedullary junction might facilitate exerting their influence via an endocrine,autocrine or paracrine pathways on the function of mature T-cells.The possible roles of thymic corpuscles are also discussed.

AIM:To study the mechanisms of effects of the ?-opioid receptor(?-OR) on neonatal rat hypertrophic myocardial cells induced by isoproterenol(ISO).METHODS:Myocardial cells of neonatal rats were cultured in vitro.The total protein content was detected by the Lowry's assay.The volume of myocardial cell was measured by computer photogragh analysis system and the protein synthesis was assayed with[3H] leucine intake method.The degree of extracellular signal-regulated kinase(ERK) phosphorylation was determined by western-blotting.RESULTS:U0126(an inhibitor of ERK) decreased the total protein content,the cell size,the[3H]leucine incorporation and the ERK phosphorylation degree in hypertrophic myocardial cells induced by ISO.1 ?mol/L U50,488H(a ?-opioid receptor antagonist) could decrease the total protein content,the cell size,the[3H]leucine incorporation and the degree of ERK phosphorylation.But these effects could be diminished when incubated with U0126.CONCLUSION:?-opioid can abolish the hypertrophic response induced by ISO of cardiac myocytes,which was associate with ERK pathway.The inhibitor of ERK significantly inhibits the ISO-induced hypertrophied effect.

In order to optimize the curriculum structure, improve the quality of the traditional med-ical curriculum which separates the theory teaching and clinical teaching in medical education; give full play to the advantages of the multiple disciplines application to guide students to establish a holistic view of medicine; cultivate students'! independent thinking and team cooperation ability, we explore the reform model of the pediatric teaching courses from the following five aspects:curriculum design, class hour arran-gement, teaching team building, teaching carrier production and application of problem-based learning (PBL) teaching method. Preliminarily establish the teaching mode in multi disciplines integration which is characterized by taking a certain symptom or sign as leading clue.