Aim To investigate the effects of com-bined treatment of SAHA and TRAIL on human breast cancer ER positive cell line MCF-7 . Methods MCF-7 cells were treated with SAHA and/or TRAIL. The inhibitory rates were detected by real-time cell prolifer-ation assays. Morphology changes of MCF-7 cells were observed through time-lapse live cell imaging acquisi-tion. Results Real-time cell proliferation assays showed that the anti-tumor efficacy of SAHA was sig-nificantly enhanced in combination with TRAIL. The results of time-lapse live cell imaging acquisition dem-onstrated that, with treatment of SAHA and TRAIL, the growth inhibition of MCF-7 cells was more obvious than that of in TRAIL or SAHA treatment alone. Con-clusion The combination treatment of SAHA and TRAIL has a synergistic effect of growth inhibition on breast cancer MCF-7 cells.

History, 20th Century ; History, 21st Century ; Otolaryngology ; history ; Otorhinolaryngologic Surgical Procedures

China ; Endoscopy ; trends ; Humans ; Otorhinolaryngologic Surgical Procedures ; trends

Anniversaries and Special Events ; Genomics ; Humans ; Internationality ; Mammography ; utilization ; Neoplasms ; diagnosis ; drug therapy ; genetics ; prevention & control

Humans ; Sleep Apnea, Obstructive ; etiology

Audiology ; trends ; China ; Humans ; Speech-Language Pathology ; Voice

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