Objective To study the effect of prevention and treatment for patients with radiation proctitis by retention enema.Methods According to the digital table,120 patients with pelvic tumor treated with radiotherapy were randomly divided into two groups.The observation group was taken retention enema 2 to 14 days after radiotherapy once a day.The control group was taken retention enema when the patients with radiation proctitis after radiotherapy.The severity and frequency of radiation proctitis were observed in the two groups.Results The incidence of radiation proctitis in the observation group was 35.0％,which was significantly lower than that of the control group (83.3％) (χ2 =47.623,P =0.000).The severity of radiation proctitis was also significantly lower than that of control group.The incidence of Ⅱ and Ⅲ degree of radiation proctitis in the observation group were 3.3％,0,respectively,which were significantly lower than those of the control group (26.7％,6.7 ％) (χ2 =12.810、4.138,P =0.000、0.042).The total efficiency rate was 100.0％,which was significantly higher than that of the control group (72.0％)(χ2 =32.558,P =0.000).Conclusion Retention enema can effectively treat the radiation proctitis and the effect will be more significant if the retention enema starts soon after radiotherapy.

OBJECTIVE:To prepare theophylline pulsed suppository(TPS)and evaluate its in vitro release characteristics.METHODS:The formulation of TPS was optimized using single factor method taking the amount of base materials including poloxamer,CMC-Na,PEG 6000 and PEG 400 as factors with lag time of drug release and the accumulative drug release rate served as indexes.The accumulative drug release rates of the TPS prepared with different fillers(crude drug of theopylline,theopylline-PVP physical mixture,and the theopylline-PVP solid dispersion)were investigated.RESULTS:The optimal formulation was as follows:70% poloxamer,6% CMC-Na,12% PEG 6000,12% PEG 400;its lag time of in vitro drug release was about 4 hours and its accumulative drug release rate at 90 min reached more than 85%.The accumulative drug release rates of the suppository prepared with 3 different fillers were 58.8%,65.8% and 91%,respectively.CONCLUSION:The prepared TPS showed satisfactory pulsed release efficacy.