0.05).Conclusion BNP and hsCRP may be involved in the occurrence and sustainment of atrial fibrillation.The serum levels of BNP and hsCRP may serve as independent indexes of atrial fibrillation.CK-MB may be not involved in the incidence and development of atrial fibrillation.

China ; Occupational Exposure ; prevention & control ; Risk Assessment ; Workplace

Objective: To explore the relationship between asymptomatic intracranial arterial stenosis and plasma lipid and uric acid levels in elderly patients with hypertension. Methods: A total of 164 elderly patients with hypertension were selected during the physical examination. Transcranial Doppler (TCD) sonography found that 56 patients had intracranial arterial stenosis (stenotic group) and 108 patients without stenosis (nonstenotic group). In addition, 36 age-and sex-matched healthy controls were selected as control group. Plasma lipid and uric acid levels were detected by automatic biochemistry analyzer in the 3 groups. Results: The levels of plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and uric acid in the stenotic group were 6.0 ± 1.1 mmol/L, 1.7 ± 0.9 mmol/L, 3.8 ± 0.9 mmol/L, and 437 ± 115 μmol/L, respectively; they were 5.4 ± 1.1 mmol/L, 1.7 ± 1.0 mmol/L, 3.3 ± 0.9 mmol/, and 372 ± 78 μmol/L, respectively in the nonstenstic group; and they were 4.9 ± 0.5 mmol/L, 1.1 ± 0.5 mmol/L, 1.42 ± 0.26 mmol/L, and 324 ± 56 μmol/L, respectively in the control group. There were significant differences between the stenotic and nonstenotic groups with the control group (P<0.001); and there were significant differences between the stenotic group and the nonstenotic group either in the levels of plasma TC, LDL-C, and uric acid (P=0.002, P=0.002, P= 0.000). Conclusion: The increase of the levels of plasma TG, LDL-C and uric acid are the risk factors of intracranial arterial stenosis in elderly patients with hypertension.

Objective To study the pre-and post-surgical orthodontic treatment methods of patients with skeletal malocclusion treated through combined orthodontic-orthognathic surgery,and to set some guidance for the future clinical Work.Methods Twenty-five skeletal malocclusion patients in our clinic aged from 17 to 36 were treated by presurgical orthodontic treatment,orthognathic surgery and postsurgical ortho dontic treatment.Presurgical orthodontic treatment included alignment of dental arches,leveling of arches,elimination of rotations,coordination of the arches,and decompensation of anterior and posterior teeth.The postsurgical orthodontic treatment included closing residual spacing,final tooth alignment,maximum interdigitation,finalizing torque,artistic positioning,ideal overjet/overbite relationship and establishment of correct root parallelism.Results The duration of presurgical orthodontic treatment was 14.41 months on average(2～23 months),and the postsurgical orthodontic treatment time was 6.94 months on average(1.5～13.5 months).The duration for the whole active treatment was 21.35 months on average(7～35 months).The maxilla was moved back on an average 5.00 mm in maxillary protrusion cases.The mandible was moved anteriorly on an average 7.25 mm in mandibular retrusion cases.The mandible was moved back on an average 6.55 mm in mandibular protrusion cases.The chin was moved anteriorly on an average 5.33 nan in retrusion of chin cases.Conclusions Pre-and post-surgical orthodontic treatments are important procedures to the surgical treatment for skeletal malocclusion and basic needs to obtain successful treatment results.

OBJECTIVE:To explore clinical efficacy of levoearnitine combined with trimetazidine in the treatment of ischemic cardiomyopathy(ICM) heart failure in elderly patients.METHODS:64 ICM elderly patients with heart failure were randomly divided into control group and observation group(n=32).Both group were given therapy of regulating blood lipid,antiplatelet,anti ischemia and conventional anti-heart failure therapy.Observation group were additionally intravenously injected with levoearnitine and given oral dose of trimetazidine for 2 weeks.Cardiac function classification,left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD) and left ventricular ejection fraction(LVEF) of patients were determined before and after treatment.RESULTS:The cardiac function and the level of LVEDD,LVESD and LVEF in observation group were all significantly better than in control group.There were statistical significance in difference between two groups(P

OBJECTIVE To comprehend characteristics and risk factors of lower respiratory tract infection after tracheotomy.METHODS Lower respiratory tract infection condition of 60 cases with tracheotomy was investigated.Risk factors were analyzed.RESULTS The prevalence of nosocomial infection was 93.3%,mainly lower respiratory tract infection(82.1%).The most common pathogens were Gram-negative bacilli.This group of patients had the seriously underlying diseases.In the treatment they carried on the trachea intubation,the tracheotomy,oxygen inhalation,sputum aspiration,atomization and so on.The time the tracheotomy and days in hospital be longer,the lower respiratory tract infection be higher.CONCLUSIONS The trachea intubation,the tracheotomy,the time of tracheotomy and the longer days in hospital may be the risk factors which can cause the lower respiratory tract infection.

Objective To detect the inhibitory effect of HSP27-siRNA on hepatocellular carcinoma(HCC) cells.Methods HCC cell QGY lines were cultured with HSP27-siRNA in a differtent range of concentration for various time periods.Cell activity was studied by MTT.The changes of cell cycle and apoptosis were analyzed by FCM.RT-PCR was used to detect the effect of HSP27-siRNA on QGY cell expression of HSP27 mRNA.Western blot was used to detect the inhibition efficiency of HSP27-siRNA on HSP27protein.Results The proliferation of QGY cell was inhibited by HSP27-siRNA,and HSP27-siRNA decreased the expression of HSP27 protein.HSP27-siRNA inhibited the proliferation of QGY cell line and induced apoptosis in vitro,and its effect was both dose-and time-dependent.Conclusions HSP27-siRNA can inhibit proliferation and induce apoptosis of HCC cancer cell lines.Thus,it may become a method for effective treatment of HCC cancer.

Objective To explore the diagnosis and treatment of regional pancreatic portal hypertension.(Methods) The clinical data of 11 cases of regional pancreatic portal hypertension were analysed(retrospectively).Results The 11 cases presented with gastric varices,splenomegaly,and pancreatic disease,but liver was normal.All cases underwent surgery,including splenectomy in 9 cases,splenectomy and distal pancreatectomy in 1 case,and other operation in 1 case.No serious complication was found postoperatively.Ten cases were followed up,no re-bleeding occurred postoperatively.Conclusions Regional pancreatic portal hypertension can be diagnosed correctly preoperatively and treated effectively.

OBJECTIVE:To evaluate the efficacy and toxicity of paclitaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer(NSCLC) by weekly-,biweekly- and three-weekly-regimens.METHODS:180 patients who had been confirmed by pathology and cytology as having NSCLC(Ⅲ～Ⅳstage) were enrolled into the study and divided to three groups:Biweekly - regimen(n= 60):paclitaxel 80 mg?m~(-2) plus cisplatin 40 mg?m~2 ivgtt on day 1 and day 8 in every 21 days;Weekly- regimen(n= 60):paclitaxel 55 mg?m~(-2) plus cisplatin 30 mg?m z ivgtt on day 1,8,and 15 in every 28 days;Three - weekly regimen(n = 60):paclitaxel 160 mg?m~(-2) plus cisplatin 80 mg?m~(-2) ivgtt on day 1 in every 21 days.Serum concentrations of paclitaxel at 3,12,24 h after administration were determined,and the efficacy and toxicity after two- cycle treatment were evaluated.RESULTS:The overall response rates of weekly-,biweekly -and three weekly regimens were 43.1%,35.8%and 34.0%respectively,showing no statistical differences among groups,but the incidence of main toxicities of biweekly-regimen was lower as compared with the other regimens.CONCLUSION:Biweekly -regimen is optimal for the treatment of advanced NSCLC with mild toxicity,which deserves to be applied in clinical practice.

Objective To evaluate the inhibitory effect of butyl flufenamate (BT) on ultraviolet (UV)-induced acute skin phototoxic reaction,and to investigate its possible mechanisms.Methods Eight SKH-1 hairless mice were included in this study.The back of each SKH-1 hairless mouse was divided into six regions,which were then randomly classified into six groups:blank group receiving no treatment,UV group receiving UV radiation only,BT + UV group and vehicle + UV group topically treated with BT ointment and vehicle respectively followed by UV radiation,UV + BT group and UV + vehicle group topically treated with BT ointment and vehicle respectively after UV radiation.Skin samples were obtained from these mice at 24 hours after treatment.Subsequently,hematoxylin-eosin (HE) staining was performed,real-time PCR was carried out to detect mRNA expressions of caspase-3,p53,COX-2,PGER1,interleukin (IL)-1β,IL-6,and an immunofluorescence assay was conducted to observe the expression of caspase-3.Statistical analysis was carried out by repeated-measures analysis of variance (ANOVA).Results Compared with the UV group,both BT + UV group and UV + BT group showed a decrease in the degree of skin edema and number of apoptotic cells at 24 hours after UV radiation.Real-time PCR showed that the mRNA expressions of caspase-3,p53,COX-2,PGER1,IL-l β and IL-6 were significantly higher in the UV group than in the blank group (all P ＜ 0.05),but significantly lower in the BT + UV group than in the UV group (all P ＜ 0.05),and only the expressions of caspase-3 and p53 mRNAs were significantly decreased in the UV + BT group compared with the UV group (both P ＜ 0.05).The immunofluorescence assay revealed that the expression of caspase-3 increased in the UV group compared with the blank group,but decreased in both BT + UV group and UV + BT group compared with the UV group.Conclusion BT could partially inhibit UV-induced acute skin phototoxicity in SKH-1 hairless mice.