0.05).Conclusion BNP and hsCRP may be involved in the occurrence and sustainment of atrial fibrillation.The serum levels of BNP and hsCRP may serve as independent indexes of atrial fibrillation.CK-MB may be not involved in the incidence and development of atrial fibrillation.

China ; Occupational Exposure ; prevention & control ; Risk Assessment ; Workplace

Objective: To explore the relationship between asymptomatic intracranial arterial stenosis and plasma lipid and uric acid levels in elderly patients with hypertension. Methods: A total of 164 elderly patients with hypertension were selected during the physical examination. Transcranial Doppler (TCD) sonography found that 56 patients had intracranial arterial stenosis (stenotic group) and 108 patients without stenosis (nonstenotic group). In addition, 36 age-and sex-matched healthy controls were selected as control group. Plasma lipid and uric acid levels were detected by automatic biochemistry analyzer in the 3 groups. Results: The levels of plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and uric acid in the stenotic group were 6.0 ± 1.1 mmol/L, 1.7 ± 0.9 mmol/L, 3.8 ± 0.9 mmol/L, and 437 ± 115 μmol/L, respectively; they were 5.4 ± 1.1 mmol/L, 1.7 ± 1.0 mmol/L, 3.3 ± 0.9 mmol/, and 372 ± 78 μmol/L, respectively in the nonstenstic group; and they were 4.9 ± 0.5 mmol/L, 1.1 ± 0.5 mmol/L, 1.42 ± 0.26 mmol/L, and 324 ± 56 μmol/L, respectively in the control group. There were significant differences between the stenotic and nonstenotic groups with the control group (P<0.001); and there were significant differences between the stenotic group and the nonstenotic group either in the levels of plasma TC, LDL-C, and uric acid (P=0.002, P=0.002, P= 0.000). Conclusion: The increase of the levels of plasma TG, LDL-C and uric acid are the risk factors of intracranial arterial stenosis in elderly patients with hypertension.

Objective To study the pre-and post-surgical orthodontic treatment methods of patients with skeletal malocclusion treated through combined orthodontic-orthognathic surgery,and to set some guidance for the future clinical Work.Methods Twenty-five skeletal malocclusion patients in our clinic aged from 17 to 36 were treated by presurgical orthodontic treatment,orthognathic surgery and postsurgical ortho dontic treatment.Presurgical orthodontic treatment included alignment of dental arches,leveling of arches,elimination of rotations,coordination of the arches,and decompensation of anterior and posterior teeth.The postsurgical orthodontic treatment included closing residual spacing,final tooth alignment,maximum interdigitation,finalizing torque,artistic positioning,ideal overjet/overbite relationship and establishment of correct root parallelism.Results The duration of presurgical orthodontic treatment was 14.41 months on average(2～23 months),and the postsurgical orthodontic treatment time was 6.94 months on average(1.5～13.5 months).The duration for the whole active treatment was 21.35 months on average(7～35 months).The maxilla was moved back on an average 5.00 mm in maxillary protrusion cases.The mandible was moved anteriorly on an average 7.25 mm in mandibular retrusion cases.The mandible was moved back on an average 6.55 mm in mandibular protrusion cases.The chin was moved anteriorly on an average 5.33 nan in retrusion of chin cases.Conclusions Pre-and post-surgical orthodontic treatments are important procedures to the surgical treatment for skeletal malocclusion and basic needs to obtain successful treatment results.

OBJECTIVE:To explore clinical efficacy of levoearnitine combined with trimetazidine in the treatment of ischemic cardiomyopathy(ICM) heart failure in elderly patients.METHODS:64 ICM elderly patients with heart failure were randomly divided into control group and observation group(n=32).Both group were given therapy of regulating blood lipid,antiplatelet,anti ischemia and conventional anti-heart failure therapy.Observation group were additionally intravenously injected with levoearnitine and given oral dose of trimetazidine for 2 weeks.Cardiac function classification,left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD) and left ventricular ejection fraction(LVEF) of patients were determined before and after treatment.RESULTS:The cardiac function and the level of LVEDD,LVESD and LVEF in observation group were all significantly better than in control group.There were statistical significance in difference between two groups(P

OBJECTIVE To comprehend characteristics and risk factors of lower respiratory tract infection after tracheotomy.METHODS Lower respiratory tract infection condition of 60 cases with tracheotomy was investigated.Risk factors were analyzed.RESULTS The prevalence of nosocomial infection was 93.3%,mainly lower respiratory tract infection(82.1%).The most common pathogens were Gram-negative bacilli.This group of patients had the seriously underlying diseases.In the treatment they carried on the trachea intubation,the tracheotomy,oxygen inhalation,sputum aspiration,atomization and so on.The time the tracheotomy and days in hospital be longer,the lower respiratory tract infection be higher.CONCLUSIONS The trachea intubation,the tracheotomy,the time of tracheotomy and the longer days in hospital may be the risk factors which can cause the lower respiratory tract infection.

Objective To detect the inhibitory effect of HSP27-siRNA on hepatocellular carcinoma(HCC) cells.Methods HCC cell QGY lines were cultured with HSP27-siRNA in a differtent range of concentration for various time periods.Cell activity was studied by MTT.The changes of cell cycle and apoptosis were analyzed by FCM.RT-PCR was used to detect the effect of HSP27-siRNA on QGY cell expression of HSP27 mRNA.Western blot was used to detect the inhibition efficiency of HSP27-siRNA on HSP27protein.Results The proliferation of QGY cell was inhibited by HSP27-siRNA,and HSP27-siRNA decreased the expression of HSP27 protein.HSP27-siRNA inhibited the proliferation of QGY cell line and induced apoptosis in vitro,and its effect was both dose-and time-dependent.Conclusions HSP27-siRNA can inhibit proliferation and induce apoptosis of HCC cancer cell lines.Thus,it may become a method for effective treatment of HCC cancer.

Objective To investigate the clinical application effect of independently designed subcutaneous tunnel in endo‐scopic thyroid operation .Methods A total of 480 cases of endoscopic thyroid operation were completed in our department from February 2005 to December 2014 ,in which 315 cases adopted the independently designed subcutaneous tunnel for separating the subcutaneous tissues in anterior thoracic region and the other 165 cases used the puncture stick for separating and constructing the subcutaneous tunnel .Results Using independently designed subcutaneous tunnel for constructing the subcutaneous tunnel in the anterior thoracic region had statistical difference in the operative time and intraoperative bleeding amount compared with the punc‐ture stick(P<0 .05) ,and the difference of postoperative complications between the two groups was statistically signifficant (P<0 .05) .Conclusion Adopting the independently designed subcutaneous tunnel for constructing subcutaneous tunnel has the advan‐tages of short time consuming ,less bleeding and fewer complications .The level and size of the constructed subcutaneous tunnel are easy to grasp ,so which is more convenient for endoscopic thyroid operation .

Background and purpose: The overall survival time of extensive-stage small cell lung cancer is not satisfactory. No chemotherapy schemes more effective than etoposide combined with cisplatin, and other optimum combinations should be under evaluation. The aim of this study was to investigate the survival advantage of IEP followed by EP chemotherapy in the treatment of extensive-stage small cell lung cancer compared with EP chemotherapy alone. Methods: From Jan 2004 to Sep 2007, 68 extensive-stage small cell lung cancer patients were enrolled in this project and were randomly divided into research group and control group in the ratio of 1:1. In the research group, 34 patients accepted IEP chemotherapy at least two times followed by EP chemotherapy maintenance therapy. 34 patients as control group accepted EP chemotherapy only. Statistical significance was defined as P<0.05. Results: The median overall survival time of the research group was 15.32 months and the control group was 9.30 months. There were no significant differences between the two groups (P=0.0787). The median time to progression of the research group was 7.83 months and 6.92 months for the control group, respectively. There were no significant differences between the two groups (P=0.0164). It is suggested that IEP followed by EP chemotherapy in treatment of extensive-stage small cell lung cancer could get a better progression free survival, but the overall survival time has not been improved. Conclusion: We conclude that those patients with extensive-stage small cell lung cancer could get better progression free survival by accepting IEP chemotherapy.

[Objective] This study compared outcomes of in vitro maturation (IVM) and in vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI) cycles after IVM of immature germinal vesicle (GV) oocytes.[Methods] ICSI was performed on metaphase II (MII) oocytes retrieved in 163 IVF-ICSI cycles (group I;n ＝ 987) or matured from GV stage oocytes in IVF-ICSI ( group II;n ＝ 132) and 37 IVM cycles ( group III;n ＝ 235).Fertilization and cleavage rates and embryo quality were compared among the three groups.[Results] The fertilization rate,cleavage rate and top quality embryos rate were higher in group I than group II and group III (84.9%,98.1%,and 61.6%;72.0%,90.5% and 22.1%l;75.3%,94.4%,and 25.1%,respectively).Blastomere numbers and morphology scores were highest in group I (P ＜ 0.05),but no significant differences existed between group II and group III.[Conclusion] The morphology of embryos developed from in vivo MII oocytes was superior to those from in vitro matured MII oocytes.No significant difference was observed in embryo morphology from immature GV oocytes in IVF and IVM cycles.