The advantages of non-contact medical monitoring radar were introduced compared with the traditional medical monitoring devices. The state of art of three kinds of typical medical monitoring radar schemes over the past decade was reviewed. Researches on breathing and heartbeat signal extraction, isolation and clutter suppression algorithms were summarized. The advantages and disadvantages of these algorithms were also pointed out. The prospects of non-contact medical monitoring radar were explored finally.

Objective To discuss application value for detecting sentinel lymphatic node(SLN) in patients with breast mass by subcutaneous injection SonoVue. Methods Forty-two cases with breast masses who were detected by conventional techniques were injected subcutaneously with 1.25 ml Sono Vue to the borderline of breast tumor at each 3,6,9, 12 points. The changes of contrast-enhanced ultrasound (CEUS) of the ipsilateral axillary SLN were observed and the start time of enhancement of lymphatic channel and lymph nodes, the position and numbers of enhancement of the lymph nodes, the time of regression were recorded. Compared with Methylene blue and surgicalbiopsy, the accuracy of detection of SLN by CEUS were evaluated. Results SLN were successfully detected in 30 of 42 patients, the detection rate was 71.4%. The total number of detected SLN was 40.Five nodes were detected in 5 of 10 (50%)patients with benign masses. Thirty-five nodes were detected in 25 of 32 (78.1%) patients with breast cancer. Fifty-seven SLN were successfully detected in 39 of 42 patients with Methylene blue, the accurate rate was 92.9%. Seven of 10 patients with benign masses and all 32 patients with breast cancer were Methylene blue positive. There were total 64 SLN found, including 11 with benign masses and 53 with lymph nodes metastasis of breast cancer cells. Conclusions The subcutaneous injection SonoVue is effective to detect SLN in patients with breast mass and apply clinical value for forecasting whether the lymph node metastases in patients with breast cancer.

Objective To assess the efficacy and safety of naloxone for treating cerebral infarction.Methods Randomized controlled trials(RCTs)and quasi-RCTs were identified from MEDLINE(1966-2005.4),EMBASE(1980-2005.4),Cochrane Controlled Trials Register(Cochrane Library issue 2,2005),CBMdisc(1978 -2005.4).We handsearched related published and unpublished data and their references.All naloxone treating for cerebral infarction were included.Data were extracted and evaluated by two reviewers independently with designed extraction form.RevMan 4.2.7 software was used for data analysis.Results Twelve RCTs involving 1075 patients were included.All the results of meta-analysis were listed as follows:(1)Total effective rate:compared with none control,5 studies showed that naloxone had a statistical difference with RR 1.24,95 %CI 1.05 to 1.46;(2)cure rate:compared with none control,naloxone had a statistical differences with RR 1.54,95%CI 1.09 to 2.18;(3)adverse effect:the number of accidence were few and representations were light.Conclusion Naloxone may increase the total effective rate and cure rate of cerebral infarction.More high quality trials are required.

The Koch's triangle of 110 human hearts (adults 70, children 40) has been dissected. The morphology, relationship and landmark of the atrioventricular node were observed and measured. Muscle bundles from the interatrial septum and coronary sinus orifice above and below are connected with the node. In the children the tendon of Todaro is usually tendinous, but in the adults, its posterior part is usually muscular. Deep in the triangle, there is a pyramidal space bounded by the left and right atrial walls and the top of the interventricular septum, in which there are vessels and nerves leading to the atrioventricular nodal area. According to their construction, the Koch's triangle is divided into five parts. The functional and surgical significance of these structures has been discussed.

Objective To appraise facial skin's quality conveniently and correctly.Methods The quality appraisal model for facial skin image was established based on improved BP nerve network algorithm,and the model was trained with the intrinsic pattern of the training sample,then the appraisal result was output after inputting indexes on the skin.Results For 23 sets of samples,the appraisal accuracy reached 95%.Conclusion The network model,with a high accuracy and a low error rate,is applicable to facial skin image quality appraisal.

This study is to investigate the effects of paeoniflorin on cerebral blood flow and the balance of PGI2/TXA2 of rats with focal cerebral ischemia-reperfusion injury. A total of 72 SD rats (3) were randomly divided into 6 groups: sham operation group, cerebral ischemia-reperfusion model group (I/R gourp), low (10 mg.kg-1), middle (20 mg.kg-1) and high (40 mg.kg-1) doses of paeoniflorin groups and nimrnodipine group. Focal cerebral ischemia in rats was made by inserting a monofilament suture into internal carotid artery for 90 min and then reperfused for 24 h. The effects of paeoniflorin on neurological deficit scores and the infarction volume of brain were detected. Relative regional cerebral blood flow (rCBF) was continuously monitored over ischemic hemispheres by laser-Doppler flowmetry (LDF). The expression of COX-2 in hippocampal CAl region was estimated by immunohistochemistry and the contents of prostacyclin I2 (PGI2), thromboxane A2 (TXA2), and ratio of PGIJ2/TXA2 in serum were measured by ELISA kits. Paeoniflorin significantly ameliorated neurological scores, reduced the infarction volume, and increased regional cerebral blood flow relative to the I/R group. In addition, paeoniflorin could inhibit COX-2 expression and the release of TXA2 and prevent the downregulation of PGI2 induced by I/R injury. The neuroprotective effects of paeoniflorin against focal cerebral ischemia-reperfusion rats might be attributed to improve the supply of injured hemisphere blood flow and adjust the balance between PGI2/TXA2.

Objective To evaluate the safety and effective dose of oxycodone hydrochloride in-jection for postoperative analgesia in breast cancer patients undergoing modified radical mastectomy under general anesthesia in a prospective,randomized controlled clinical trial.Methods One hundred fe-male patients at ASAⅠ or Ⅱ,aged 29-69 years,BMI< 30 kg/m2 ,scheduled for elective modified radical mastectomy under general anesthesia,were randomly divided into two groups (n =50):low dose oxycodone hydrochloride injection group (group OL),and high dose oxycodone hydrochloride injection group (group OH).Oxycodone 0.03 mg/kg (group OL)and 0.09 mg/kg (group OH)was intravenous injected 30 mi-nutes before the end of the operation,respectively.Anesthetics usage was terminated when skin was sutured.Pain at rest and during movement was assessed using VAS score at 5 min,0.5,2,4,8,12 and 24 h after extubation of laryngeal mask.Total consumption of analgesic for rescue analgesia in the ward and the adverse events were recorded.Results Compared with group OL,group OH had lower VAS scores,There were significant differences in the VAS scores between groups at 8 and 12 h after surgery (P <0.05).No serious adverse event occurred in each group postoperatively.The most common adverse event was nausea, followed by vomiting and dizziness.There was no significant difference in the incidence of adverse event be-tween the two groups.Conclusion 0.09 mg/kg oxycodone hydrochloride injection is safe and effective in re-ducing pain after breast cancer radical operation.

Objective To investigate the FH/Wjd rat model of alcoholic liver disease.Methods Thirty-six 16-18 week old SPF grade FH/Wjd rats (male:female=1:1) were used in this study.The rats were divided into two groups randomly by body weight:water intake group and alcohol intake group.The rats took water or alcohol freely.16 weeks lat-er, ALT, AST, TBIL, TG, CHO in the serum and TG, GSH in the liver homogenate were detected.The expression of PPARαprotein in the liver tissue was detected by Western blot.The apoptosis rate of liver cells was assessed by flow cy-tometry.The pathological changes of liver tissue were examined using HE staining.Results Compared with the water in-take group, the serum TBIL and TG were significantly increased in rats of both sexes of the alcohol intake group, moreover, ALT and CHO of the female rats in the alcohol intake group were significantly decreased.TG in the liver homogenate in-creased obviously, while GSH in the liver homogenate showed a decreasing tendency.Hepatocyte apoptosis in rats of both sexes in the alcohol intake group showed an increasing tendency.The PPARαprotein expression was up-regulated obvious-ly, and the main pathological change in the liver tissue was microvesicular fatty degeneration.Conclusion Spontaneous long-term alcohol intake can induce liver injuries in FH/Wjd rats.

Objective To compare the esophageal acid and alkaline exposure characteristics of patients with cardia carcinoma after proximal gastrectomy or total gastrectomy.Method A total of 77 patients of cardia carcinoma who underwent radical resection from Sep 2007 to Sep 2011 in our hospital were retrospectively reviewed.24 hour esophageal pH monitoring were performed in all patients.Result Patients were divided into three groups:group TG had total gastrectomy (n =25),group PP had proximal gastrectomy with pyloroplasty (n =33),group NP had proximal gastrectomy (n =19).It revealed that indicators of acid reflux including the overall time length of acid episodes,＞ 5 min times of acid episodes,duration of longest acid episodes,time length of pH ＜ 4.00 and the DeMeester Scores in group NP were significantly higher than in group PP(U =32,P ＜ 0.01 ; U =35,P ＜ 0.01 ; U =23,P ＜ 0.01 ; U =39,P ＜0.01 ;U =49,P ＜0.01 respectively).Only alkline reflux was observed in group TG.The total times of alkaline episodes in PP group was significantly lower than in group TG(U =52,P ＜0.01) and group NP (U =182,P ＜0.01).＞5 min times of alkaline episodes in group TG was larger than in group PP,and that in group PP was larger than in group NP(P ＜0.01).Duration of longest alkaline episodes and total period of pH ＞7.00 in group PP was significantly higher than in group TG(U =125,P ＜ 0.01 ; U =143.5,P ＜ 0.01),and that in group TG was higher than in group NP(U =23.5,P ＜ 0.01 ; U =14,P ＜ 0.01).Conclusions Alkaline reflux deserves more attention in evaluating esophageal reflux in patients with cardia carcinoma after resection.Pyloroplasty is not helpful to relieving esophageal acid episodes while causing severe alkaline reflux.

BACKGROUND:There are less reports on how to successfuly build the internal spatial configuration of tissue-engineered tooth scaffolds.
OBJECTIVE:To find a way to establish a series of three-dimensional digital modes for tissue-engineered tooth scaffold, such as CAD spatial configuration and Standard Template Library (STL) files.
METHODS:In order to get three-dimensional printing format of STL files, MICRO CT data of DICOM format were input into MIMICS and GEOMAGIC softwares, creating the outline of STL files. Then CATIA V5R17 software was used to create the three-dimensional digital mode of tissue-engineered tooth. Then, the overal model of the internal scaffold was obtained by arraying at the proper coordinates. Various overal scaffold configurations could be built rapidly by varying monomer configuration. The STL files of CAD model of three-dimensional printing tissue-engineered tooth were obtained by assembling the tooth outline mode and the internal scaffold.
RESULTS AND CONCLUSION: The CAD model was constructed successfuly, and this model could be directly used for three-dimensional printing rapid prototyping system to produce tissue-engineered tooth scaffolds. These findings indicate that the three-dimensional digital mode based on reverse engineering and positive engineering can be established, which can be used to quickly build a variety of internal spatial configurations of scaffold materials required for tissue-engineered teeth.