No abstract available.
Metronidazole

No abstract available.
Fibroblasts* ; Metronidazole*

Quantitation of Metronidazole by reversed phase liquid chromatography using Supelco LC-ABZ column and a mobile phase containing an acid aqueous phase (pH Metronidazole ; Tablets

Forty-three patients with papulo-pustular rosacea with Demodex(D.) folliculorum were treated for 8 weeks on a random basis either with tetracycline 250 mg three times daily or with metronidazole 250 mg three times daily. Both drugs produced an improvement which was greater after 8 weeks than after 4 weeks, but there was no significant difference between them. The number of D. follilculorum after treatment with tetracycline was slightly decreased, but the number of D. folliculorum after treatment with metronidazole was more decreased than the tetracycline group. Metronidazole appears to be a effective drug for the treatment of rosacea with D. folliculorum.
Humans ; Metronidazole* ; Rosacea* ; Tetracycline*

Microcapsules of metronidazole with ethyl cellulose have been prepared by coacervation technique and spray drying technique. The microcapsulated ratio of metronidazole was evaluated. Core: wall ratio and preparing method influenced significally on the release of metronidazole from microcapsules
Capsules ; Pilot Projects ; metronidazole

No abstract available.
Cryotherapy* ; Leishmaniasis, Cutaneous* ; Metronidazole*

No abstract available.
Dermatitis* ; Metronidazole* ; Tacrolimus*

No abstract available.
Brain Diseases ; Metronidazole

BACKGROUND: Metronidazole susceptibility and the presence of Trichomonas vaginalis virus (TVV) are the phenotypes found to be significantly correlated with the microsatellite-based genotypes of T. vaginalis. These phenotypes were assessed in T. vaginalis isolates from select urban areas to determine preliminary "type" of Philippine T. vaginalis.

METHODS: Culture and microscopy were used to detect T. vaginalis in vaginal swab samples collected from women attending social hygiene clinics in Metro Manila and Angeles City, Philippines. Screening of TVV on T. vaginalis was performed using RNA gel electrophoresis and RT-PCR. A modified protocol for metronidazole susceptibility assay was used to determine the aerobic minimum lethal concentration (MLC) of metronidazole in axenized T. vaginalis isolates.

RESULTS: A total of 42 T. vaginalis were screened for the presence of TVV and assayed for metronidazole susceptibility. TVV was detected in 13 of the isolates. All but one of the samples was susceptible to metronidazole.

CONCLUSION: This is the first study to assess the in vitro metronidazole susceptibility of Philippine T. vaginalis isolates. The isolates are generally susceptible to metronidazole even with the presence of TVV. The metronidazole susceptibility and presence of TVV are not enough to classify the isolates into type 1 or type 2.

Growing increase in resistance of H. pylori strains to antibiotics of choice is identified worldwide, requiring further investigating susceptible characteristics of the germ to these agents. Objectives: To assess the resistance of H. pylori individual colonies from a single biopsy to metronidazole and clarithromycin. Methods: The E - test was used to determine the Minimum Inhibitory Concentrations (MICs) of these two antimicrobial drugs for ten H. pylori colonies isolated from an initial gastric biopsy culture from each of 14 adults and 14 children. Results: Among patients haboring HP strains resistant to these 2 antimicrobials, we observed heterogeneity in metronidazole resistance in 14/22 cases and in clarithromycin resistance in 3/13 cases. The number of resistant individual colonies ranged from 2/10 to 9/10 depending on subjects. Conclusions: In the same biopsy from both adults and children different colonies of H. pylori displayed different antimicrobial susceptibility patterns prior to anti - H. pylori treatment, rendering antibiogram interpretation difficult.
Helicobacter pylori, Adult, Child, Metronidazole