No abstract available.
Methotrexate*

No abstract available.
Methotrexate*

Hypertrophic lichen planus (HLP) is a papulosquamous eruption presenting with extremely pruritic hyperkeratotic flat-topped papules, plaques, and nodules. This is a case of 38-year-old male who presented with a 2-month history of generalized erythematous-to-hyperpigmented papules, patches, and plaques topped with white-to-gray oyster shell-like scales on a background of hyperpigmented macules and patches. There was no involvement of the conjunctival, otic, oral, and genital mucosae, and palmar and plantar aspects of the hands and feet. Dermoscopy showed reticular pearly white structures corresponding to the Wickham striae, comedo-like openings, blue-gray dots, brownish-black dots, and scales. Histopathologic examination revealed marked compact hyperkeratosis, wedge-shaped hypergranulosis, irregular saw-toothed epidermal acanthosis, scattered dyskeratotic keratinocytes, and superficial perivascular lichenoid infiltrate of lymphocytes, histiocytes, and melanophages. The patient was managed as a case of HLP. He was started on methotrexate 10 mg per week, bath psoralen photochemotherapy (PUVA) three times a week, betamethasone valerate 1mg/g cream twice a day for 2 weeks alternating with tacrolimus 0.1% ointment twice a day for another 2 weeks, 10% lactic acid, emollients, and sunscreen. After 6 months of treatment, there was almost 80% improvement of lesions and relief of pruritus.
Methotrexate

No abstract available.
Methotrexate* ; Psoriasis*

No abstract available.
Methotrexate* ; Pregnancy*

No abstract available.
Methotrexate* ; Pregnancy*

No abstract available.
Methotrexate* ; Skin*

Psoriasis is a systematic immune-mediated inflammatory disease where there is an increased cell turnover of the skin leading to scaling, drying, and erythema. The occurrence of pemphigus foliaceus, an autoimmune blistering disease (AIBD) characterized by flaccid bullae and erosions, is rare when concomitantly present with psoriasis. Treatment options for these diseases may overlap. We report a case of a 44-year-old female who presented with both psoriasis and pemphigus foliaceus successfully treated with methotrexate.
Pemphigus ; Methotrexate

A prospective study was conducted on 33 psoriasis patients treated with methotrexate (MTX) 0.1mg/kg in continuous 5 days at the Dermatological Department of the Army Central hospital from 2000-2004. Results: MTX had high effect in treatment of usual psoriasis (very good: 24.24%; good: 21.21%; relatively good: 45.45%; medium 9.10%); it had early effect (at the first round) and had effect on all kinds of psoriasis: usual type (with the severe level, PASI reduced 64.76%; average 70.99%; light: 94.86%) DDTT type (PASI reduced 73.63%). After methotrexate therapy, 45.45% of patients had a increased rate of SGOT, 39.39% had a increased rate of SGPT; the number of white blood cells decreased in 9.1% of patients, and red blood cells and platelet decreased in 3% of patients . Additionally, the treatment also caused some other symptoms such as fatigue in 10/33 patients (30.3%), anorexia in 13/33 patients (39.40%). The researcher suggested: do not use MTX at daily dose to treat psoriasis.
Psoriasis ; Therapeutics ; Methotrexate

No abstract available.
Cytomegalovirus* ; Humans* ; Methotrexate* ; Papaverine*