1.Clinical Observation of Dds Induced Methemoglobinemia.
Hee Seon AUH ; Kwan Hwooy CHO ; Kir Young KIM ; Duk Jin YUN ; Sook Pyo KWON
Journal of the Korean Pediatric Society 1983;26(3):257-264
No abstract available.
Methemoglobinemia*
2.Value of methemoglobinemia and its clinical significant
Journal of Practical Medicine 2002;407(1):13-16
The high level of Methemoglobinemia influences the combination of blood with oxygen and oxygen transfer to cells which can lead to the life in the normal condition. Methemoglobine is a component of erythrocyte in a very small amount(less than 1% of total Hemoglobine). An increased Methemoglobine leads to the disorder of oxygen delivery. The clinical symptoms are direct proportional with the methemoglobinemia level. The hypermethmoglobinemia includes the congenital- methemoglobinemia and the acquired methemoglobinemia. The congenital hypermethemoglobinemia attibuted to a partly or completed deficiency of Methemoglobine reductase in patients with the deficiency of genetic heterozygous - enzyme or abnormal methemoglobine: the acquired methemoglobinemia occurred after exposure with the chromatic compound, food, water with much nitrate or use of some drugs. The quantitative analysis of methemoglobinemia has a values in the diagnosis, treatment and prognosis
Methemoglobinemia
;
Prognosis
3.Congenital methemoglobinemia.
Journal of the Philippine Medical Association 2018;97(1):33-41
This report a case of a ten-year-old female
with progressive cyanosis and dyspnea on exertion.
Clinical and laboratory work up ruled out a cardiac
and pulmonary pathology warranting further
investigation for possible hemoglobinopathies.
Enzyme assay showed deficiency in cytochrome b5
reductase seen in patients with congenital
methemoglobinemia. Ascorbic acid at 200mg daily
afforded gradual improvement in cyanosis.
Methemoglobinemia
;
Cyanosis
4.Clinical Observation of The Methemoglobinemia in Childrens.
Hak Hew SHIN ; Chull Kwon CHUNG ; Myung Hi SHIN ; Ji Sub OH
Journal of the Korean Pediatric Society 1982;25(11):1131-1140
No abstract available.
Child*
;
Humans
;
Methemoglobinemia*
5.Role of ascorbic acid in dapsone induced methemoglobinemia
Kamal Kant SAHU ; Ajay Kumar MISHRA
Clinical and Experimental Emergency Medicine 2019;6(1):91-92
No abstract available.
Ascorbic Acid
;
Dapsone
;
Methemoglobinemia
6.Methemoglobin and treatment of hypermethemolobinemia
Journal of Medical Research 2002;18(2):61-65
The hyper-methemoglobinemia causes the oxygen transfer disorder. The clinical symptoms depends on the level of methemoylobinemia. Hypermethemoglobinemia can be congenital or acquired hypermethemoglobinemia. The congenital hypermethemoglobinemia caused by partial or total methemoglobine reeducates deficiency in patients with rare genetic heterozygous enzyme deficiency due to the abnormal hemoglobin. The acquired hypermethemoglobinemia occurred after exposure to colour compound, food and drinking water with nitrate or drugs. The determination of causative agent of hypermethemoglobin help treating more effectively
Methemoglobin
;
Hemoglobins, Abnormal
;
Therapeutics
;
Methemoglobinemia
7.Inaccurate Reading of Pulse Oximeter Due to Methemoglobinemia: A case report.
Korean Journal of Anesthesiology 1999;37(5):927-930
Pulse oximeters measure the arterial oxygenation by determining the color of the blood between a light source and a photodetector. The light source consists of two light-emitting diodes (LEDs) that emit light at known wave lengths, 660 nm red light and 940 nm infrared light. The ratio of pulse-added red absorbance at 660 nm to pulse-added infrared absorbance at 940 nm is used to generate the oximeter's estimate of arterial saturation (SpO2). Pulse oximeters can determine the concentration of only two hemoglobins, reduced (HHb) and oxyhemoglobin (HbO2), so they can't distinguish the dyshemoglobins (methemoglobin, carboxyhemoglobin) which have light absorbances similar to that of HHb or HbO2. If the concentration of dyshemoglobin is above the normal range, pulse oximeters would give erroneous SpO2 readings. We experienced a case which showed a low SpO2 reading but had normal ABGA findings due to unsuspected methemoglobinemia.
Methemoglobinemia*
;
Oxygen
;
Oxyhemoglobins
;
Reading
;
Reference Values
8.Effect of N-acetylcysteine on Dapsone-Induced Methemoglobinemia.
Wen Joen CHANG ; Seung Ho KIM ; Hahn Shick LEE
Journal of the Korean Society of Emergency Medicine 1997;8(2):150-154
BACKGROUND: To determine whether N-acetylcysteine(NAC) reduces methemoglobin. METHOD: We carried out an in vivo experiment in rats, weighed about 300g. Each rat was ingested 200mg of dapsone(4,4'diaminodiphenyl sulphone) to induce methemo- globinemia. After 1 hour, 30 rats were received NAC 160mg(2ml) and another 30 rats, served as control, were received 2ml of normal saline orally,4 times hourly. Serum methemoglobin concentrations were checked 1,6, and 24 hours after dapsone ingestion. RESULT: The methemoglobin concentrations on each time were 27.1+/-5.8%,23.5+/-8.8%, 17.1+/-6.4%(mean+/-SD) in control group and 25.5+/-6.3%, 25.5+/-8.8%, 65.5+/-31.2%(mean+/-SD) in NAC group. There were no differences on methemoglobin concentrations at 1 and 6 hours between two groups(P>.05). At 24 hours, the methemoglobin concentrations of NAC group was significantly higher than those of control group(P<.01). CONCLUSION: NAC had no therapeutic effects on dapsone induced methemoglobinemia in this experimental setting.
Acetylcysteine*
;
Animals
;
Dapsone
;
Eating
;
Methemoglobin
;
Methemoglobinemia*
;
Rats
9.A Case of Congenital Methemoglobinemia Due to NADH-Methemoglobin Reductase Deficiency.
Do Hyeon KIM ; Jin A LEE ; Sung Jae LEE ; Heui Seung JO ; Yun Kyoung LEE ; June Dong PARK ; Beyong Il KIM ; Jung Hwan CHOI ; Dong Soon LEE ; Han Ik CHO ; Kyung Ran PARK
Journal of the Korean Pediatric Society 2001;44(6):699-704
Congenital methemoglobinemia is caused by NADH-methemoglobin reductase deficiency in more than half of the total reported cases. NADH-methemoglobin reductase deficiency is an uncommon hereditary disorder producing methemoglobinemia and cyanosis in the homozygous subject. A majority of the patients born with these abnormalities have only a cosmetic defect-asymptomatic cyanosis. Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency is an autosomal recessive disorder and classified into 4 types according to the pathophysiology of the disorder. In type I, the deficiency of NADH-methemoglobin reductase is restricted to erythrocytes of patients with mild cyanosis, and 7 missence mutations have been reported in the case of type I. We report the first Korean pediatric case of type I congenital methemoglobinemia due to NADH- methemoglobin reductase deficiency with a review of the literature.
Cyanosis
;
Cytochrome-B(5) Reductase
;
Erythrocytes
;
Humans
;
Methemoglobinemia*
;
Oxidoreductases*
10.Acute dapsone intoxication: The dosage of activated charcoal and methylene blue.
Sung Pil CHUNG ; Tae Sik HWANG ; Sung Wook CHOI ; Seung Ho KIM ; Hahn Shick LEE
Journal of the Korean Society of Emergency Medicine 1997;8(2):277-282
BACKGROUND: Methemoglobinemia(MetHb) induced by dapsone overdose is not uncommon in Korea, especially in rural area. For treatment of dapsone-induced methemoglobinemia, methylene blue(MB) and activated charcoal(AC) should be used. To date, no reports have compared the amount of MB used between MB alone with MB & AC combined group(MB+AC). And also between moderate (MetHb<35%) and severe (MetHb>35%) intoxicated group defined by initial MetHb level. Authors hypothesized that less amount of MB can be used if MB and AC was used together and larger amount of MB is necessary to reduce MetHb level to asymptomatic level in severely intoxicated group. METHODS: From Jan 1990 to Dec 1996, a total of 54 patients who received treatment for dapsone intoxication were subject of study, The study was done retrospective chart analysis for initial MetHb level, total amount of MB and AC. Wilcoxon rank sum test and Chi-sqiare test was used to compare the total dosage of MB used for each group. Linear regression analysis was used between initial MetHb and the total amount of MB. Results were considered statistically significant when p<0.05. RESULTS: For MB alone and MB+AC group, the differences in total amount of MB used were statistically significant with mean dosage of 7.14+/-1.1mg/kg and 4.28+/-0.7mg/kg, respectively. And total amount of MB used between moderate and severe intoxicated group, the differences were statistically significant with mean dosage of 5.16+/-1.1mg/kg vs. 10.98+/-1.9mg/kg, respectively. There was significant correlation between initial MetHb level (X) and the amount of methylene blue (Y), Y=0.3X-2.42 (r2=0.41, p=0.0001) in MB alone, Y=0.186X-1.95(r2=0.21, p=0.034) in MB+AC respectively. CONCLUSION: For methemoglobinemia induced by dapsone, total amount of MB can be reduced especially in severe Intoxicated group if AC use was combined in treatment modality. There was significant correlationship between initial MetHb level and total amount of MB used.
Charcoal*
;
Dapsone*
;
Humans
;
Korea
;
Linear Models
;
Methemoglobinemia
;
Methylene Blue*
;
Retrospective Studies