Objective:To investigate the influence of gradually induced occlusion disorder on temporomandibular joint in young rabbits. Methods: The upper first premolar on one side and the lower first premolar on the other side of 18 New Zealand white rabbits at the age of 7 months, were pulled forward with the orthodontic string, making them inclined medially to the anterior intrinsic space. The TMJs were removed 1,2 and 3 months respectively after set up and observed histologically. Results: In the 1 month group,TMJs exhibited regressive remodeling on the lateral side. In the 2 month group,the joints simultaneously showed progressive remodeling and degenerative changes.The TMJ condyle cartilage were thinner than the controls.Conclusion: Gradually induced occlusion disorders can lead TMJ degenerative changes in young rabbit.